2007 Fiscal Year Final Research Report Summary
High functional nanobio surface modification of titanium implant with bone morphogenetic protein
| Project/Area Number |
18592127
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Hiroshima University |
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Principal Investigator |
ABE Yasuhiko Hiroshima University, Hospital, Assistant Professor (00253097)
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| Co-Investigator(Kenkyū-buntansha) |
AKAGAWA Yasumasa Hiroshima University, Graduate School of Biomedical Sciences, Professor (00127599)
OKAZAKI Masayuki Hiroshima University, Graduate School of Biomedical Sciences, Professor (30107073)
HIRATA Isao Hiroshima University, Graduate School of Biomedical Sciences, Assistant Professor (40346507)
YOSHIDA Yasuhiro Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Associate Professor (90281162)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Implant / Titanium / Surface modification / Phospho-cell adhesion molecul / Bone morphogenetic protein / Osteoblast |
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| Research Abstract |
The purpose of this study was to investigate a mechanism on binding and dissociation of phospho-amino acids and phospho-peptide to titanium surface, and to evaluate a surface modification technique for titanium surface using recombinant human bone morphogenetic protein (BMP) -2.
1. Surface plasmon resonance (SPR) analyses clarified that phosphate functional group adsorbed to the surface of the titanium-SPR sensor involving the phenomenon to dissolve the nano-thin layer of the surface.
2. An application of a water solube carbodiimide (WSC) for the surface modified with o-phospho-L-serine enabled these graft polymerization of bovine serum albumin fraction V and recombinant human BMP-2 to the surface.
Consequently, it was concluded that the molecule with phosphate functional group and WSC were greatly available for biochemical surface modification process of titanium implant with recombinant human BMP-2.
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