2007 Fiscal Year Final Research Report Summary
Study of odontotherapy rerated-osteonecrosis of the jaw following to long-term bisphosphonate application
| Project/Area Number |
18592162
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
DEYAMA Yoshiaki Hokkaido University, Grad., Sch., Dent Med., Associate Professor (80271667)
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| Co-Investigator(Kenkyū-buntansha) |
TOTSUKA Yasunori Hokkaido University, Grad., Sch., Dent Med., Professor (00109456)
TEI Kanchu Hokkaido University, Grad., Sch., Dent Med., Asso. Prof. (80180066)
IIZUKA Tadashi Hokkaido University, Grad., Sch., Dent Med., Associate Professor (80168062)
YOSHLMURA Yoshitaka Hokkaido University, Grad., Sch., Dent Med., Assistant Professor (30230816)
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| Project Period (FY) |
2006 – 2007
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| Keywords | bisphosphonate / osteonecrosis / odontotherapy |
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| Research Abstract |
Intravenous bisphosphonates are primarily used and effective in the treatment and management of cancer-related conditions. These include hypercalcemia of malignancy, skeletal-related events associated with bone metastases in the context of solid tumors such as breast cancer, prostate cancer, and lung cancer, and in the management of lytic lesions in the setting of multiple myeloma. Oral bisphosphonates are approved to treat osteoporosis and are frequently used to treat osteopenia as well. They are also used for a variety of less common conditions such as Paget's disease of bone, and osteogenesis imperfecta of childhood. Recently, cases of nonhealing exposed, necrotic bone in the maxillofacial region in patients treated with intraveneous bisphosphonates, pamidronate and zoledronic acid, have been recognized and reported. To date, the incidence and pathophysiology of osteonecrosis of the jaw (ONJ). In this study, we aimed to elucidate the mechanism of ONJ.
ONJ typically appears as an area of exposed alveolar bone that can occur in the mandible or the maxilla. We hypothesis that pathogen in oral cavity might be involved in the etiology of ONJ, and focused to toll like receptors (TLRs), which recognize microviral antigens to provoke innate immunity and establish adaptive immunity.
TLR3 stably expressed in osteoblastic MC3T3-E1 cells. Poly (I):poly (C) induced interferon-β (IFN-β) mRNA, and which enhanced TLR3 expression in autocrin manner via IFN-α/β receptor, IFNAR, following by STAT1 phosphorylation.
LPS treatment decrease in cell viability in pamidronate-pretreated macrophage-like RAW 264 cells. Moreover, high concentration of pamidronate and zoledronic acid suppressed inflammatory cytokines, such as interleukin-1β and tumor necrosis factor-α. High concentration Bps might suppress innate immunity system in the osteoblasts.
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[Presentation] Innate immunity signal in osteoblast2008
Author(s)
Deyama Y, Nakamura K, Yoshimura Y, Nakamura K, Tei K, Totsuka Y, Suzuki K
Organizer
The 81th Annual Meeting of The Japanese Pharmacological Society
Place of Presentation
Pacifico Yokohama (Yokohama)
Year and Date
2008-03-17
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 「研究成果報告書概要(欧文)」より2007
Author(s)
Nakamura K, Deyama Y, Yoshimura Y, Suzuki K, Morita M
Organizer
The 30^<th> Annual Meeting of the Molecular Biology Society of Japan
Place of Presentation
Pacifico Yokohama (Yokohama)
Year and Date
2007-12-11
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[Presentation] Function of TLR signaling in osteoblast2007
Author(s)
Deyama Y, Nakamura K, Yoshimura Y, Morita M, Suzuki K
Organizer
The 58^<th> North Blanch Meeting of The Japanese Pharmacological Society
Place of Presentation
Hokkaido University (Sapporo)
Year and Date
2007-09-29
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Effects of TLR ligands on osteoblasts2007
Author(s)
Nakamura K, Deyama Y, Yoshimura Y, Suzuki K, Morita M
Organizer
5^<th> Annual Meeting of The Japanese Society for Animal Cytokine Research
Place of Presentation
Rakuno Gakuen University (Ebetsu)
Year and Date
2007-09-01
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Estrogen and joint disorders2007
Author(s)
Galal N, E1-Beialy WR, Deyama Y, Yoshimura Y, Suzuki K, Totsuka Y
Organizer
49th Annual Meeting of Japanese Association for Oral Biology
Place of Presentation
Hokkaido University (Sapporo)
Year and Date
2007-08-30
Description
「研究成果報告書概要(欧文)」より
