2009 Fiscal Year Final Research Report
The mechanism of abnormal secretion of saliva in patients with Sjogren's syndrome.
| Project/Area Number |
18592186
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
OHYAMA Yukiko Kyushu University, 歯学研究院, 助教 (70294957)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMUA Seiji 九州大学, 大学院・歯学研究院, 教授 (60189040)
FUJII Jun 九州大学, 大学院・歯学研究院, 准教授 (60271441)
SHIRASUNA Kanemitsu 九州大学, 大学院・歯学研究院, 名誉教授 (30093420)
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| Project Period (FY) |
2006 – 2009
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| Keywords | シェーグレン症候群 / 唾液分泌異常 / ドライマウス / 塩酸セビメリン |
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| Research Abstract |
Treatment with cevimeline hydrochloride in patients with Sjogren's syndrome is significantly effective to patients who had mild destruction of salivary glands. "nzm-1858", an anti salivary glands monoclonal antibody established from model mice of SS, reacts to human salivary ductal cells, and cevimeline hydrochloride is more effective to salivary glands which have positive reaction to nzm-1858 in immunohistchemical staining. Antigen to nzm-1858 is 69kDa protein and we are analyzing this protein.
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