Regulatory effects of methoxyphenols on the transcription factor activation in mammalian cells.

2009 Fiscal Year Final Research Report

• Project/Area Number: 18592197
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Meikai University
• Principal Investigator: MURAKAMI Yukio Meikai University, 歯学部, 准教授 (00286014)
• Project Period (FY): 2006 – 2009
• Keywords: 口腔外科学一般(含病態検査学)

Research Abstract

We investigated the regulatory effects of methoxyphenols such as BHA, bis-BHA, o-vanillin, guaiacol, curcumin, tetrahydrocurcumin, phenol and biphenol, on the transcription factor activation stimulated by LPS or other stimulants in mammalian cells. Methoxyphenols which hardly abstracted an H atom from the phenolic OH group inhibited a transcriptional activity of redox-sensitive transcription factors, and suppressed COX-2 and cytokine expression. These observations suggested that methoxyphenol compounds possessed a therapeutic potential against chronic inflammation and mutagenesis by its phenol function.

Research Products

• [Journal Article] Antioxidant and cyclooxygenase-2-inhibiting activity of 4, 4'-biphenol, 2, 2'-biphenol and phenol. (2009)
  • Author(s): Murakami, Y., Ishii, H., Hoshina, S., Takada, N., Ueki, A., Tanaka, S., Kadoma, Y., Ito, S., Machino, M., Fujisawa, S.
  • Journal Title: Anticancer Res. 29 Pages: 2403-2410
• [Journal Article] Comparative anti-inflammatory activities of curcumin and tetrahydrocurcumin based on the phenolic O-H bond disociation enthalpy, ionization potential and quantum chemical descriptor. (2008)
  • Author(s): Murakami Y., Ishii, H., Takada, N., Tanaka, S., Machino, M., Ito, S., Fujisawa, S.
  • Journal Title: Anticancer Res. 28 Pages: 699-708
• [Journal Article] Predicting the biological activities of 2-methoxyphenol antioxidants: Effects of dimers. (2007)
  • Author(s): Fujisawa, S., Ishihara, M., Murakami, Y., Atsumi, T., Kadoma, Y., Yokoe, I.
  • Journal Title: In Vivo. 21 Pages: 181-188
• [Journal Article] Re-evaluation of cyclooxygenase-2-inhibiting activity of vanillin and guaiacol in macrophages stimulated with lipopolysaccharide. (2007)
  • Author(s): Murakami, Y., Hirata, A., Ito, S., Shoji, M., Tanaka, S., Yasui, T., Machino, M., Fujisawa, S.
  • Journal Title: Anticancer Res. 27 Pages: 801-808
• [Journal Article] An ortho dimer of butylated hydroxyanisole inhibits nuclear factor kappa B activation and gene expression of inflammatory cytokines in macrophage stimulated by Porphyromonas gingivalis fimbriae. (2006)
  • Author(s): Murakami, Y., Shoji, M., Hirata, A., Tanaka, S., Hanazawa, S., Yokoe, I., Fujisawa, S.
  • Journal Title: Arch. Biochem. Biophys. 449 Pages: 171-177
• [Journal Article] Preventive effect of ortho dimer of butylated hydroxyanisole on activator protein-1 activation and cyclooxygenase-2 expression in macrophages stimulated by fimbriae of Porphyromonas gingivalis, an oral anaerobe. (2006)
  • Author(s): Murakami, Y., Shoji, M., Ogiwara, T., Tanaka, S., Yokoe, I., Fujisawa, S.
  • Journal Title: Anticancer Res. 26 Pages: 2915-2920
• [Presentation] p-クレゾール二量体によるLPS刺激TNF-α発現の調節作用 (2009)
  • Author(s): 石井宏明, 村上幸生, 保科修平, 高田直樹, 藤澤盛一郎, 町野守
  • Organizer: 第63回日本口腔科学会
  • Place of Presentation: 浜松
  • Year and Date: 20090400
• [Presentation] フェノール関連二量体化合物によるLPS刺激TNF-α発現の抑制作用 (2008)
  • Author(s): 村上幸生, 石井宏明, 高田直樹, 丸山剛央, 湯原健司, 保科修平, 小林聡子, 細谷明代, 田中庄二, 藤澤盛一郎, 町野守
  • Organizer: 第21回日本口腔診断学会
  • Place of Presentation: 東京
  • Year and Date: 20080900
• [Book] Molecular Targets and Therapeutic Uses of Spices. Modern Uses for Ancient Medicine(Chapter 5 Cloves (Eugenol)) (2009)
  • Author(s): Kadoma, Y., Murakami, Y., Atsumi, T., Ito, S., Fujisawa, S.
  • Total Pages: 117-148
  • Publisher: World Scientific Publishing Co. Pre. Ltd.