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2007 Fiscal Year Final Research Report Summary

The efficacy of biotin on the skin diseases related to dental Rats a

Research Project

Project/Area Number 18592202
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTokyo Dental College

Principal Investigator

TAKAHASHI Shinichi  Tokyo Dental College, DEPARTMENT OF DENTISTRY, PROFESSOR (90197145)

Co-Investigator(Kenkyū-buntansha) KAWASHIMA Junko  TOKYO DENTAL COLLEGE, DEPARTMENT OF DENTISTRY, LECTURER (00208357)
MORIMOTO Mitsuaki  TOKYO DENTAL COLLEGE, DEPARTMENT OF DENTISTRY, LECTURER (90174458)
YAMANE Genyuki  TOKYO DENTAL COLLEGE, DEPARTMENT OF DENTISTRY, PROFESSOR (80096510)
Project Period (FY) 2006 – 2007
Keywordspustulosis palmoplantaris / biotin / dental focus / metal allergy / IL-6
Research Abstract

We investigated 18 patients with pustular palmoplantaris (PPP) on the existence of osteoarthritis, periodontitis and the efficacy of biotin by scoring the severity of eruption with PPPASI (palmoplantar Pustular Psoriasis Area Severity Index). We also analyzed CD4/8 and plasma concentration of TNF-a , IL-6 and biotin before and after biotin treatment. Serum concentration of biotin was measured by competitive enzyme-linked assay.
We found osteoarthritis (39%), periodontitis (56%) very frequently in these patients. However, these complications did not correlate with severity of eruptions. Elevations of plasma concentrations of IL-6 was detected in 4 of our patients, although there wasno significant. changes of CD4/8 and TNF-a . In these 4 cases three patients had severe periodontitis and one had pyelonephritis
Serum concentration of biotin was about 100 times higher in the patients with administration of 9 or 12mg of biotin daily than those without biotin treatment. There was no significant difference of serum biotin concentration between patients with 9mg daily and those with 12mg daily. This result means 9mg of biotin per''day is enough for the treatment of the patients with PPP.
Biotin was very effective for 14(78%)patients investigated. PPPASI of the patients was significantly lowered after biotin treatment (p<0.01). Biotin was also effective for the osteoarthritis. Serum IL-6 concentration was significantly decreased after biotin treatment (p<0.01). Furthermore, we confirmed synergic effect of dental treatment on eruptions and osteoarthritis of the patients with PPP.
These results indicate IL-6 may be a useful marker for severe periodontitis in the patients with PPP. We also suggest biotin (9mg daily) together with dental treatment for periodontitis is quite effective for PPP.

  • Research Products

    (22 results)

All 2008 2007 2006

All Journal Article (8 results) (of which Peer Reviewed: 4 results) Presentation (14 results)

  • [Journal Article] 扁平苔癬2008

    • Author(s)
      高橋 愼一, 川島 淳子, 森本 光明, 山根 源之, 他
    • Journal Title

      皮膚病診療 30

      Pages: 381-384

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Lichen planus(in Japamsese)2008

    • Author(s)
      Takahashi. S., Kawashima. J., Morimoto. M., Yamane. G., et. al.
    • Journal Title

      Hihubyoushinryo 30

      Pages: 381-384

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 歯科と金属アレルギー2007

    • Author(s)
      高橋 愼一
    • Journal Title

      アレルギーの臨床 27

      Pages: 795-800

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] 皮膚科との連携を必要とする口腔粘膜疾患2007

    • Author(s)
      高橋 愼一
    • Journal Title

      日本歯科評論 (増刊)

      Pages: 196-202

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] マウス遅延型過敏反応モデルを用いた歯科用金属アレルギーにおけるパッチテスト客観化2007

    • Author(s)
      高田 篤史, 森本 光明, 山根 源之, 高橋 愼一, 他
    • Journal Title

      日本口腔科学会雑誌 56

      Pages: 226-233

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Dentistry and metal allergy(in Japanses)2007

    • Author(s)
      Takahashi., S
    • Journal Title

      Allergy in Practice 27

      Pages: 795-800

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Oral mucosal disorder in collaboration with Dermatologist(in Japansese)2007

    • Author(s)
      Takahashi., S
    • Journal Title

      Nihon Shika Hyoron(supple)

      Pages: 196-202

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 「研究成果報告書概要(欧文)」より2007

    • Author(s)
      Takada. A., Morimoto. M., Yamane. G., Takahashi. S., et. al.
    • Journal Title

      Japanese Journal of Stomatology 56

      Pages: 226-227

  • [Presentation] 金属アレルギーが増悪因子となったOral pemphigusの1例2007

    • Author(s)
      伊東 祥雄, 高橋 愼一, 森本 光明, 山根 源之, 他
    • Organizer
      第1回日本皮膚アレルギー、接触皮膚炎学会
    • Place of Presentation
      名古屋
    • Year and Date
      20071200
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] A case of oral pemphigus associated with metal allergy2007

    • Author(s)
      Ito. Y., Takahashi. S., Morimoto, M., Yamane. Genyuki., et. al.
    • Organizer
      1st Annual Meeting of Japanese Academy of Dermatoallergology and contact dermatitis
    • Year and Date
      20071200
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] レジンに含まれるHEMAによる接触粘膜炎と考えられた3例2007

    • Author(s)
      矢部 健太郎, 森本 光明, 山根 源之, 高橋 愼一, 他
    • Organizer
      第17回日本口腔粘膜学会総会、学術大会
    • Place of Presentation
      東京
    • Year and Date
      20070700
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 粘膜類天庖瘡に対し局所ステロイド薬密封療法を行った3例2007

    • Author(s)
      酒井 克彦, 森本 光明, 山根 源之, 高橋 愼一, 他
    • Organizer
      第17回日本口腔粘膜学会総会、学術大会
    • Place of Presentation
      東京
    • Year and Date
      20070700
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Three cases of contact stomatitis due to HEMA in resin2007

    • Author(s)
      Yabe, K., Morimoto. M., Yamane. G., Takahashi. S., et. al.
    • Organizer
      17th Annual Meeting of Japanese Academy of oral mucosal membrane
    • Place of Presentation
      Tokyo
    • Year and Date
      20070700
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Three cases of mucous membrane pemphigoid treated with occlusive dressing technique of steroid ointment2007

    • Author(s)
      Sakai. K., Morimoto. M., Yamane. G., Takahashi. S., et. al.
    • Organizer
      17 th Annual Meeting of .Japanese Academy of oral mucosal membrane
    • Place of Presentation
      Tokyo
    • Year and Date
      20070700
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 皮膚、口腔粘膜におけるニッケル感作マウスを用いた遅延型過敏反応に関する実験的研究2006

    • Author(s)
      藤本 勝, 森本 光明, 山根 源之, 高橋 愼一, 他
    • Organizer
      第282回東京歯科大学学会(総会)
    • Place of Presentation
      稲毛
    • Year and Date
      20061100
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Experimental study of delayed hypersensitivity in mouse model of nickel sensitization via skin and oral mucosa2006

    • Author(s)
      Fujimoto. M., Morimoto. M., Yamane. Genyuki., Takahashi, S., et. al.
    • Organizer
      282, th meeting of Tokyo Dental College Academy
    • Place of Presentation
      Inage
    • Year and Date
      20061100
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 類天疱瘡の経過観察中に骨髄異形成症候群(MDS)を合併した1例2006

    • Author(s)
      高田 篤史, 森本 光明, 高橋 愼一, 出根 源之, 他
    • Organizer
      第16回日本口腔粘膜学会総会、学術大会
    • Place of Presentation
      新潟
    • Year and Date
      20060700
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] A case of mucous membrane Pemphigoid associated with Myelodysplastic Syndromes2006

    • Author(s)
      Takada. A., Morimoto. M., Takahashi. S., Yamane G., et. al.
    • Organizer
      16th Annual Meeting of Japanese Academy of oral mucosal membrane
    • Place of Presentation
      Niigata
    • Year and Date
      20060700
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 口腔扁平苔癬に対するタクロリムス軟膏の臨床的検討2006

    • Author(s)
      森本 光明, 山根 源之, 高橋 愼一, 他
    • Organizer
      第60回特定非営利活動法人 日本口腔科学会
    • Place of Presentation
      名古屋
    • Year and Date
      20060500
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Clinical assessment of the efficacy of t : tacrolimus ointment on oral-lichen planus2006

    • Author(s)
      Morimoto. M., Yamane. G., Takahashi. S., et. al.
    • Organizer
      60th Annual Meeting ofJapanese Stomatological Assocation
    • Place of Presentation
      Nagoya
    • Year and Date
      20060500
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Hemifacial trial of VitaminC sonopheresis in melasma2006

    • Author(s)
      Kawashima.J., Takahashi.S., et. al.
    • Organizer
      First Congress of the international dermoscopy society
    • Place of Presentation
      ナポリ
    • Year and Date
      20060400
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Hemifacial trial of VitaminC sonopheresis in melasi2006

    • Author(s)
      Kawashima. J., Takahashi. S., et. al.
    • Organizer
      1th Congress of the International Dermoscopy Society
    • Place of Presentation
      Naples
    • Year and Date
      20060400
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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