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2008 Fiscal Year Final Research Report

Roles of MAPKs in molecular response to mechanical stimulation in chondrocytes

Research Project

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Project/Area Number 18592228
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionTohoku University

Principal Investigator

TAKAHASHI Ichiro  Tohoku University, 大学院・歯学研究科, 准教授 (70241643)

Project Period (FY) 2006 – 2008
Keywords軟骨細胞分化 / 機械的刺激応答 / 細胞内情報伝達 / ERK-1 / 2 / 細胞接着 / MAPK阻害剤 / 圧縮力 / 牽引力
Research Abstract

本研究では、機械的伸展刺激負荷にともない、ERKのリン酸化が起こること、さらに、ERK-1/2の活性化阻害剤を培養系に添加することにより、分化中の軟骨細胞のメカニカルストレスレスポンスを阻害できることをII型コラーゲンの遺伝子発現の半定量的解析により解明した。これにより、ERK-1/2を介した細胞内情報伝達系が軟骨細胞の機械的刺激受容機構において細胞外からの刺激を核内に伝達している可能性が示唆された。

  • Research Products

    (11 results)

All 2009 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (7 results)

  • [Journal Article] Molecular mechanisms of mechanical stress response during chondrogenesis2009

    • Author(s)
      Takahashi I, Masuda T, Kohsaka K, Terao F, Anada T, Sasano Y, Takano-Yamamoto T, Suzuki O
    • Journal Title

      J Biomech Sci Eng (in press)

    • Peer Reviewed
  • [Journal Article] The differentiation of chondrocytes under cyclic mechanical strain by unique culture system2007

    • Author(s)
      Masuda T, Takahashi I, Anada T, Arai F, Fukuda T, Takano-Yamamoto T, Suzuki O
    • Journal Title

      J Biotechol 13

      Pages: 231-238

    • Peer Reviewed
  • [Journal Article] Mechanobiological signal transduction in differentiating chondrocyte and new configuration for mechanical stress culture2007

    • Author(s)
      Takahashi I, Masuda T, Arai F, Anada T, Fukuda T, Suzuki O, Takano-Yamamoto T
    • Journal Title

      Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems

      Pages: 1061-1064

    • Peer Reviewed
  • [Journal Article] Mechanical stretch inhibits chondrogenesis through ERK1/2 phosphorylation in micromass culture2007

    • Author(s)
      Takahashi I, Terao F, Masuda T, Sasano Y, Suzuki O, Takano-Yamamoto T
    • Journal Title

      Interface Oral Health Science 2007

      Pages: 161-166

    • Peer Reviewed
  • [Presentation] Molecular mechanisms of response to mechanical stimulation in chondrocyte differentiation2009

    • Author(s)
      Takahashi I
    • Organizer
      The 3rd International Symposium for Interface Oral Health Science
    • Place of Presentation
      Sendai
    • Year and Date
      20090115-16
  • [Presentation] 硬組織形成細胞の分化とメカニカルストレス2008

    • Author(s)
      鈴木治, 高橋一郎, 益田泰輔, 山本照子, 新井史人
    • Organizer
      第31回日本バイオレオロジー学会
    • Place of Presentation
      東京
    • Year and Date
      20080605-06
  • [Presentation] 軟骨細胞における機械的刺激応答の分子機構について2008

    • Author(s)
      高橋一郎, 益田泰介, 高坂久美子, 寺尾文恵, 笹野泰之, 鈴木治, 山本照子
    • Organizer
      第5回東北大学バイオサイエンスシンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2008-05-19
  • [Presentation] 機械的伸展刺激はERK1/2シグナルの活性化を介して軟骨細胞の分化を抑制する2008

    • Author(s)
      高橋一郎, 寺尾文恵, 高坂久美子, 益田泰介, 笹野泰之, 鈴木治, 山本照子
    • Organizer
      第29回東北骨代謝研究会
    • Place of Presentation
      仙台
    • Year and Date
      2008-02-02
  • [Presentation] Development of mechanical strain cell culture system for mechanobiological analysis2007

    • Author(s)
      Masuda T, Takahashi I, Matsui A, Arai F, Takano-Yamamoto T, Suzuki O
    • Organizer
      第2回International Symposium for Interface Oral Health Science in Sendai
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      20070218-19
  • [Presentation] Mechanobiological signal transduction in differentiating chondrocyte and new configuration for mechanical stress culture2007

    • Author(s)
      Takahashi I, Masuda T, Arai F, Anada T, Fukuda T, Suzuki O, Takano-Yamamoto Y
    • Organizer
      IEEE-NEMS
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      20070116-19
  • [Presentation] 軟骨細胞の機械的刺激応答機構におけるMAPKが果たす役割2007

    • Author(s)
      高橋一郎, 益田泰輔, 寺尾文恵, 笹野泰之, 鈴木治, 山本照子
    • Organizer
      第4回東北大学バイオサイエンスシンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2007-06-04

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Published: 2010-06-10   Modified: 2016-04-21  

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