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2007 Fiscal Year Annual Research Report

メタボリックシンドロームに及ぼす歯周病の影響についての総合的研究

Research Project

Project/Area Number 18592271
Research InstitutionAichi Gakuin University

Principal Investigator

松原 達昭  Aichi Gakuin University, 歯学部, 教授 (30209598)

Co-Investigator(Kenkyū-buntansha) 成瀬 桂子  愛知学院大学, 歯学部, 准教授 (30387576)
小林 泰子  愛知学院大学, 歯学部, 講師 (40418926)
野口 俊英  愛知学院大学, 歯学部, 教授 (50014262)
稲垣 幸司  愛知学院大学短期大学部, 歯科衛生学科, 教授 (50211058)
吉成 伸夫  松本歯科大学, 歯学部, 教授 (20231699)
Keywordsメタボリックシンドローム / 歯周病 / 心血管病 / 脂質代謝異常 / 高血圧 / 糖尿病
Research Abstract

我々は、メタボリックシンドロームと歯周病の関連についての総合的研究を実施するにあたって、当院歯周病科通院中で本研究に同意の得られた患者における血管機能およびサイトカインを含めた検討を行った。口腔内所見、う蝕、修復物・補綴物の状態、さらに,歯周病所見は歯周病専門医により診断され、歯周組織の診査は、15mmの歯周プローブ(UNC15, Hu-Friedy, USA)を使用し、第3大臼歯を除く全歯を6点法でプロービングデプス(PD)、アタッチメントレベル(AL)、プロービング時の歯肉出血(BOP)を測定し、評価した。また、デンタルX線写真から歯槽骨吸収状態を、Scheiの方法に準じて第3大臼歯を除く全歯の近遠心の歯槽骨吸収率を計測し、その平均や20%以上と50%以上の歯槽骨吸収を示す比率をそれぞれ計算した。メタボリックシンドロームの診断は日本内科学会における診断基準を用い、メタボリックシンドローム構成因子との関連を検討した。これまでの解析において、歯周病患者におけるメタボリックシンドロームの有病率は高く、さらにメタボリックシンドローム保有群では現在歯数が有意に少なく、逆にBOP陽性率、プラークスコアが高い傾向を認めた。メタボリックシンドローム構成因子との関連においては、空腹時血糖と中性脂肪が歯周病と強い相関を認めた。こうした結果は、メタボリックシンドロームを保有する患者において、歯周病の存在を示唆するのみでなく、診断基準でメタボリックシンドロームを保有しないとされる患者においても、メタボリックシンドローム構成因子に注目し、歯周病診断にあたる必要があることを示していると考えられた。現在、さらに人数を増やして解析を行うとともに、歯周病治療がメタボリックシンドロームに及ぼす影響について前向き研究を行っている。

  • Research Products

    (38 results)

All 2008 2007

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Presentation (26 results)

  • [Journal Article] Cilostazol improves long-term patency after percutaneous transluminal angioplasty in hemodialysis patients with peripheral artery disease.2008

    • Author(s)
      Ishii H
    • Journal Title

      Clinical Journal of the American Society of Nephrology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis.2008

    • Author(s)
      Aoyama T
    • Journal Title

      Circulation Journal 72

      Pages: 56-60

    • Peer Reviewed
  • [Journal Article] Abnormal glucose regulation is associated with lipid-rich coronary plaque. Relationship to insulin resistance.2008

    • Author(s)
      Amano T
    • Journal Title

      Journal of American College of Cardiology: Cardiovascular Imaging 1

      Pages: 39-45

    • Peer Reviewed
  • [Journal Article] Effect of intravenous nicorandil and preexisting angina pectoris on short-and long-term outcomes in patients with a first ST-segment elevation acute myocardial infarction.2007

    • Author(s)
      Ishii H
    • Journal Title

      American Journal of Cardiology 99

      Pages: 1203-1207

    • Peer Reviewed
  • [Journal Article] Angiotensin II receptor blocker inhibits neointimal hyperplasia through regulation of smooth muscle-like progenitor cells.2007

    • Author(s)
      Yamada T
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology 27

      Pages: 2363-2369

    • Peer Reviewed
  • [Journal Article] 歯周病と全身疾患との関係 ペリオドンタルメディスン(Periodontal Medicine)の潮流を読む〜いま明らかになっていること〜(下)2007

    • Author(s)
      野口俊英
    • Journal Title

      日本歯科衛生学会雑誌 1

      Pages: 6-20

    • Peer Reviewed
  • [Journal Article] Long-term stability of guided tissue regeneration therapy in intrabony defects: A case-control study.2007

    • Author(s)
      Yoshinari N
    • Journal Title

      Dentistry in Japan 36

      Pages: 127-130

    • Peer Reviewed
  • [Journal Article] The relationship between dental health and sister chromatid exchange(SCE).2007

    • Author(s)
      Nagamatsu K
    • Journal Title

      Aichi-Gakuin Dental Science 20

      Pages: 1-6

    • Peer Reviewed
  • [Journal Article] Effects of erbium, chromium: yttrium, scandium, gallium, garnet(Er, Cr: YSGG)laser irradiation on the root surface: morphological analysis and efficiency of calculus removal.2007

    • Author(s)
      Ting C-C
    • Journal Title

      Journal of Periodontology 78

      Pages: 2156-2164

    • Peer Reviewed
  • [Journal Article] Assessment of mandibular buccal and lingual cortical bones in postmenopausal women.2007

    • Author(s)
      Naitoh M
    • Journal Title

      Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 104

      Pages: 545-550

    • Peer Reviewed
  • [Journal Article] Arginine-specific gingipain A from Porphyromonas gingivalis induces Weibel-Palade body exocytosis and enhanced activation of vascular endothelial cells through protease-activated receptors.2007

    • Author(s)
      Inomata M
    • Journal Title

      Microbes and Infection 9

      Pages: 1500-1506

    • Peer Reviewed
  • [Journal Article] KK-Periome for periodontal ligament development: Expression profiles of the extracellular matrix genes.2007

    • Author(s)
      Nishida E
    • Journal Title

      Gene 404

      Pages: 70-79

    • Peer Reviewed
  • [Presentation] Abnormal glucose regulation is associated with lipid rich coronary plaque:relationship to insulin resistance2008

    • Author(s)
      Amano T
    • Organizer
      The 72nd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-30
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Impact of insulin resistance on elevation of post-procedural cardiac biomarker and long-tern clinical outcomes in patients underwent elective coronary intervention.2008

    • Author(s)
      Uetani T
    • Organizer
      The 72nd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-30
  • [Presentation] Impact of plaque burden at the left main coronary artery in patients with diabetes mellitus2008

    • Author(s)
      Uchida Y
    • Organizer
      The 72nd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Impact of metabolic syndrome on various aspects of microcirculation and clinical outcomes in patients with ST-segment elevation myocardial infarction.2008

    • Author(s)
      Uchida Y
    • Organizer
      The 72nd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-29
  • [Presentation] Aortic valvular calcification predicts restenosis after implantation of drug-eluting stents in patients on chronic hemodialysis.2008

    • Author(s)
      Ishii H
    • Organizer
      The 72nd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-29
  • [Presentation] Intravenous nicorandil before reperfusion prevents left ventricular remodeling in patients with acute myocardial infarction.2008

    • Author(s)
      Ishii H
    • Organizer
      The 72nd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-28
  • [Presentation] Impact of matrix metalloproteinase-2 levels on long-term results following pharmacological or electrical cardioversion in patients with atrial fibrillation.2008

    • Author(s)
      Kato K
    • Organizer
      The 72nd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-28
  • [Presentation] MMA Increases GSTa1 Promoter Activity.2007

    • Author(s)
      Hattori N
    • Organizer
      Proceedings of the International Dental Materials Congress 2007
    • Place of Presentation
      Bangkok
    • Year and Date
      2007-11-23
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Ankle brachial pressure index is individually useful for risk stratification of coronary, cerebral and peripheral artery related events in hemodialysis patients.2007

    • Author(s)
      Aoyama T
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orland
    • Year and Date
      2007-11-14
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Volumetric analysis of coronary plaque characterization in patients with metabolic syndrome using 64-slice multi-detector computed tomography(MDCT).2007

    • Author(s)
      Arai K
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orland
    • Year and Date
      2007-11-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Intravenous nicorandil before reperfusion prevents left ventricular remodeling in patients with acute myocardial infarction.2007

    • Author(s)
      Ishii H
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orland
    • Year and Date
      2007-11-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Impact of ranal dysfunction on uptake of F-18 fluorodeoxyglucose on positron emission tomography in arterial plaques.2007

    • Author(s)
      Ishii H
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orland
    • Year and Date
      2007-11-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Cilostazol improves long-term patency after percutaneous transluminal angioplasty in hemodialysis patients with peripheral artery disease.2007

    • Author(s)
      Kumada Y
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orland
    • Year and Date
      2007-11-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Elevated brain natriuretic peptide and C-reactive protein interactively increased cardiovascular and all-cause mortality risk in hemodialysis patients.2007

    • Author(s)
      Funahashi K
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orland
    • Year and Date
      2007-11-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Comparison of tissue characteristics between acute coronary syndrome and stable angina pectoris: an integrated backscatter intravascular ultrasound analysis of culprit and non-culprit lesions.2007

    • Author(s)
      Amano T
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orland
    • Year and Date
      2007-11-07
  • [Presentation] High prevalence of cardiac valve calcification and its association with future cardiovascular morbidity and mortality in end-stage renal disease patients at beginning of hemodialysis therapy.2007

    • Author(s)
      Tanaka M
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orland
    • Year and Date
      2007-11-06
  • [Presentation] Silent brain infarction predicts cardiovascular events and mortality in long-term hemodialysis patients.2007

    • Author(s)
      Aoyama T
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orland
    • Year and Date
      2007-11-06
  • [Presentation] Impact of insulin resistance on post-procedural cardiac biomarker and long-term clinical outcomes in patients underwent elective coronary intervention.2007

    • Author(s)
      Uetani T
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orland
    • Year and Date
      2007-11-05
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Abnormal glucose regulation is associated with lipid-rich plaque: involvement of insulin resistance.2007

    • Author(s)
      Amano T
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orland
    • Year and Date
      2007-11-05
  • [Presentation] Aortic valvular calcification predicts restenosis after implantation of drug-eluting stents in patients on chronic hemodialysis.2007

    • Author(s)
      Ishii H
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orland
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Coronary intervention improves both cardiac and all-cause survival compared with medication alone in hemodialysis patients with single-vessel disease-A propensity matched analysis.2007

    • Author(s)
      Aoyama T
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orland
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 2型糖尿病患者における歯周治療前後のHbA1cおよび血清中の高感度CRPレベルに関する多施設前向き研究-糖尿病治療法の影響-2007

    • Author(s)
      片桐さやか
    • Organizer
      第50回秋季日本歯周病学会
    • Place of Presentation
      東京
    • Year and Date
      2007-09-21
  • [Presentation] Osteoclasts generated in ectopic bone are derived from postmitotic osteoclast precursors(pOCPs)2007

    • Author(s)
      Muto A
    • Organizer
      The 29th annual meeting of American Society for Bone and Mineral Research
    • Place of Presentation
      Honolulu
    • Year and Date
      2007-09-19
  • [Presentation] Oral health and smoking in pregnant women.2007

    • Author(s)
      Inagaki K
    • Organizer
      The 47th Annual Scientific Meeting of the Australia and New Zealand Division of the International Association for Dental Research
    • Place of Presentation
      South Australia
    • Year and Date
      2007-07-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 自然発症糖尿病ラットの歯周組織の加齢変化とSMP30の発現2007

    • Author(s)
      近藤敏生
    • Organizer
      第18回日本老年歯科医学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-06-12
  • [Presentation] 自然発症糖尿病ラットにおける歯周組織の加齢変化について2007

    • Author(s)
      近藤敏生
    • Organizer
      第50回春季日本歯周病学会
    • Place of Presentation
      横須賀
    • Year and Date
      2007-05-18

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Published: 2010-02-04   Modified: 2016-04-21  

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