2007 Fiscal Year Final Research Report Summary
Development of new therapy for vitreoretinal disorders with enzymatic vitreolysis
Project/Area Number |
18599005
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Ophthalmology
|
Research Institution | Saga University |
Principal Investigator |
HIRATA Akira Saga University, Department of Ophthalmology, Associate Professor (60295144)
|
Project Period (FY) |
2006 – 2007
|
Keywords | plasmin / vitrectomv |
Research Abstract |
Establishment of vitreous surgery with plasmin: After institutional review board approval, vitrectomy with using plasmin was performed for 6 eyes of 4 patients. All eyes treated with autologous plasmin required significantly less surgical time. Also, we published our data regarding beneficial results in the surgical management of proliferative diabetic retinopathy and retinopathy of prematurity usefulness. All eyes showed visual Effect of bevacizumab on choriocapillaris : We presented that bevacizumab injected into the vitreous cavity caused decrease of the number of fenestrae in choriocapillaris Effect of retinal sealant with enzymatic vitreolysis : We are still investigating the effect of retinal sealant with enzymatic vitreolysis on experimental retinal detachment in rabbit eye.
|
Research Products
(6 results)
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[Journal Article] Y-27632, a Rho-associated protein kinase inhibitor, attenuates neuronal cell death after transient retinal ischemia2008
Author(s)
Hirata, A., Inatani, M., Inomata, Y., Yonemura, N., Kawaji, T., Honjo, M., anihara, TH
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Journal Title
Graefes Arch Clin Exp Ophthalmol 246
Pages: 51-59
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Autologous plasmin assisted vitrectomy for stage 5 retinopathy of prematurity2007
Author(s)
Tsukahara Y, Honda S, Imai H, Kondo N, Fujii S, Yokoyama N, Hirata A, Kawaji T, Fukushima M, Tanihara H, Negi A.
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Journal Title
Am.J.Ophthalmol. 144
Pages: 139-141
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Plasmin-assisted vitrectomy for management of proliferative membrane in proliferative diabetic retinopathy.2007
Author(s)
Hirata, A., Talcano, A., Inomata, Y., Yonemura, N., Sagara, N., Tanihara, H
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Journal Title
Retina 27
Pages: 1074-1078
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Autologous plasmin assisted vitrectomy for stage 5 retinopathy of prematurity2007
Author(s)
Tsukahara, Y., Honda, S., Imai, H., Kondo, N., Fujii, S., Yokoyama, N., Hirata, A., Kawaji, T., Fukushima, M., Tanihara, H., Negi, A
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Journal Title
Am. J. Ophthalmol 144
Pages: 139-141
Description
「研究成果報告書概要(欧文)」より