2007 Fiscal Year Final Research Report Summary
Symptoms and sleep problems associated with restless legs syndrome among Japanese General population
| Project/Area Number |
18603012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
睡眠学
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| Research Institution | Nihon University |
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Principal Investigator |
UCHIYAMA Makoto Nihon University, School of Medicine, Professor (20221111)
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| Project Period (FY) |
2006 – 2007
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| Keywords | restless legs syndrome / abnormal sensation / involuntary movement / sleep / epidemiology / insomnia / hypersomnia / insufficient sleep |
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| Research Abstract |
The objectives of the study was to investigate characteristics of restless legs syndrome (RLS) among a large sample taken from the general population of Japan. The presence of RLS was established by asking the subjects if they experienced a crawling sensation in their legs after going to bed. The survey was performed in June 2000, targeting a sample that was randomly selected from 300 communities throughout Japan. The questionnaire contained questions focusing on health consciousness, mental health, and sleep. A total of 26 705 participants completed the questionnaire. The prevalence of RLS was 3.0%, with a significant predominance in women. The prevalence of RLS increased significantly with advancing age. Multiple logistic regression analysis revealed that RLS was significantly associated with difficulty initiating sleep (odds ratio, OR = 2.58), excessive daytime sleepiness (OR = 2.28), difficulty maintaining sleep (OR = 1.71), non-restorative sleep (OR = 1.51), subjective insufficient sleep (OR = 1.36), and early morning awakening (OR = 1.21). These results suggest that the prevalence of RLS in Japan is lower than in northern European populations and that RLS is strongly associated with difficulty initiating sleep and excessive daytime sleepiness. As for the relation between RLS and other psycho-somatic complaints, Multiple logistic regression analysis revealed that RLS was significantly associated with palpitation/shortness of breath (OR=1.81), fragility (OR=1.55), backache (OR=1.50), constipation/diarrhea (OR=1.38), concern about health (OR=1.30), tenseness (OR=1.29), epigastric discomfort (OR=1.24) and stiff neck/shoulder (OR=1.24) in descending order of OR. These findings suggest that RLS involves not only deteriorated nocturnal sleep but also various somatic and psychological symptoms in the daytime.
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