2007 Fiscal Year Final Research Report Summary
Role of IL-23/Th17 axis in allergic airway inflammation
| Project/Area Number |
18604003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
アレルギー
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| Research Institution | Chiba University |
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Principal Investigator |
HIROSE Koichi Chiba University, University Hospital, Dept of Allergy and clinical Immunology, Assistant Professor (90400887)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Hiroshi Chiba University, Graduate School of Meclicine, Dept of Molecular Genetics, Professor (00322024)
WATANABE Norihiko Chiba University, University Hospital, Dept of Allergy and clinical Immunology, Associate Prof (20375653)
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| Project Period (FY) |
2006 – 2007
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| Keywords | asthma / eosinophilic inflammation / IL-23 / IL-17 / Th17 / neutrophilic inflammation |
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| Research Abstract |
IL-23-IL-17 producing CD4^+ T cell (Th17 cell) axis seems to play an important role in the development of chronic inflammatory diseases including autoimmune diseases. In this study, we show that IL-23 and Th17 cells enhance Th2 cell-mediated allergic airway inflammation using a mouse model of asthma. We found that IL-23 mRNA was expressed in the lung of sensitized mice upon antigen inhalation. We also found that neutralization of IL-23 decreased antigen-induced eosinophil recruitment and Th2 cytokine production in the airways. Furthermore, the enforced expression of IL-23 in the airways significantly enhanced antigen-induced eosinophil recruitment and Th2 cytokine production in the airways, goblet cell hyperplasia, and airway hyperresponsiveness. Moreover, although adoptive transfer of antigen-specific Th17 cells alone did not induce eosinophil recruitment into the airways upon antigen inhalation, the cotransfer of Th17 cells with Th2 cells significantly enhanced antigen-induced, Th2 cell-mediated eosinophil recruitment into the airways. These results suggest that IL-23-Th17 cell axis upregulates Th2 cell-mediated eosinophilic airway inflammation by at least two mechanisms; IL-23 enhances the activation of Th2 cells in the effector phase and antigen-specific Th17 cells cooperate to enhance Th2 cell-mediated eosinophil recruitment into the airways.
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Research Products
(10 results)
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[Journal Article] Overlapping and Distinct Roles of STAT4 and T-bet in the Regulation of T Cell Differentiation and Allergic Airway Inflammation2008
Author(s)
Furuta S, Kagami S, Tamachi T, Ikeda K, Fujiwara M, Suto A, Hirose K, Watanabe N, Saito Y, Iwamoto I, Nakajima H.
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Journal Title
J Immunol 180
Pages: 6656-6662
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-γ production and the induction of Th1 cell differentiation2007
Author(s)
Tokumasa N, Suto A, Kagami S, Furuta S, Hirose K, Watanabe N, Saito Y, Shimoda K, Iwamoto I, Nakajima H.
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Journal Title
Description
「研究成果報告書概要(欧文)」より
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