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2007 Fiscal Year Final Research Report Summary

In vivo patch-clamp analysis of developmental changes in the spinal nociceptive circuit.

Research Project

Project/Area Number 18613009
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pain science
Research InstitutionKyushu University

Principal Investigator

FURUE Hidemasa  Kyushu University, Graduate School of Medical Sciences, Assistant Professor (20304884)

Co-Investigator(Kenkyū-buntansha) YOSHIMURA Megumu  Kyushu University, Graduate School of Medical Sciences, Professor (10140641)
Project Period (FY) 2006 – 2007
Keywordssynaptic transmission / nrimary afferent / spinal cord / neuronal circuit / C fiber / electrophysiology / neuron / mechanoreceptor
Research Abstract

Developmental changes in the spinal nociceptive synaptic transmission were examined using slice and in vivo patch-clamp recordings. In transverse spinal cord slices of young and adult rats at lumbar spinal levels with an attached dorsal root, electrical dorsal root stimulation was applied to record the evoked-synaptic responses in substantia gelatinosa (SG, lamina II of the spinal cord)and deep lamina (lamina III-IV) neurons. In the in vivo patch-clamp analysis, patch electrodes were inserted into the SG at the spinal level of L3-L5 after a thoracolumbar laminectomy was performed under urethane anesthesia. Whole-cell recordings were obtained from SG neurons, and then modality-dependent synaptic responses evoked by cutaneous natural mechanical stimuli applied to the ipsilateral hind limb were recorded. In adult rats, monosynaptic Aβ and C fiber-evoked EPSCs were elicited in SG neurons. Additionally, monosynapitc Aβ fiber-evoked EPSCs were evoked in the deeper lamina neurons but not in SG neurons. In young rats, on the other hand, monosynaptic Aβ fiber-evoked EPSCs were observed in SG neurons in addition to Aβ and C fiber-evoked responses. In the in vivo patch-clamp analysis, pinch stimulation elicited a barrage of EPSCs in SG neurons in young and adult rats. Even in SG neurons that received synaptic inputs from only Aβ fibers, pinch stimulation evoked a barrage of EPSCs. Most deep neurons in adult rats responded to touch stimulation. The present results suggest that Aβ fibers, in addition to Aδ and C fibers, convey noxious mechanical information to SG neurons in young rats. In adult rats with further development of neuronal circuits in the spinal dorsal horn, innocuous mechanical synaptic responses are mediated only through Aβ fibers in deep lamina neurons.

  • Research Products

    (92 results)

All 2008 2007 2006

All Journal Article (23 results) (of which Peer Reviewed: 8 results) Presentation (68 results) Book (1 results)

  • [Journal Article] Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation2007

    • Author(s)
      Furue H., et. al.
    • Journal Title

      Journal of Neuroscience 27

      Pages: 3466-3476

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Cell type specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro2007

    • Author(s)
      Yasaka T., et. al.
    • Journal Title

      Journal of Physiology(London) 581(2)

      Pages: 603-618

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Slow oscillation of membrane currents mediated by glutamatergic inputs of rat somatosensensory cortical neurons:in vivo patch-clamp analysis2007

    • Author(s)
      DoiA., et. al.
    • Journal Title

      European Journal of Neuroscience 26(9)

      Pages: 2565-2575

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor2007

    • Author(s)
      Tsuda M, et. al.
    • Journal Title

      Journal of Neurochemistry 102(5)

      Pages: 1658-1668

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Electrophysiological analysis of plastic changes in nociceptive transmission2007

    • Author(s)
      Furue H, et. al.
    • Journal Title

      ペインクリニック 28(1)

      Pages: 93-105

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The role of GABA_B receptor in spinal nociceptive transmission2007

    • Author(s)
      Takeshima K, et. al.
    • Journal Title

      Pain Research 22

      Pages: 33-41

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Function of spinal GABA receptor and its modulation2007

    • Author(s)
      Yoshimura M, et. al.
    • Journal Title

      麻酔 56

      Pages: S141-151

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Recent insights into mechanisms for analgesic effect by calcitonin2007

    • Author(s)
      Ito A, et. al.
    • Journal Title

      日本臨床 65(S9)

      Pages: 386-390

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cadherin-8 is Required for the First Relay Synapses to Receive Functional Inputs from Primary Sensory Afferents for Cold Sensation2007

    • Author(s)
      Fume, H., Suzuki,SC.,Koga, K., Jiang, N., Nohmi,M., Shimazaki,Y., Katoh-Fukui,Y., Yokoyama,M., Yoshimura, M.,Takeichi M.
    • Journal Title

      Journal of Neuroscience 27

      Pages: 3466-3476

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cell type specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro.2007

    • Author(s)
      Yasaka,T., Kato, G., Fume,H., Rashid,MH., Sonohata,M., Tamae,A., Murata,Y., Masriko,S., Yoshimura M.
    • Journal Title

      Journal of Physiology(London) 581(2)

      Pages: 603-618

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Slow oscillation of membrane currents mediated by glutamatergic inputs of rat somatosensory cortical neurons : in vivo patch-clamp analysis2007

    • Author(s)
      Doi,A., Mizuno, M.,Katafuchi,T., Fume, H., Koga, K., YoshimuraM.
    • Journal Title

      European Journal of Neuroscience 26(9)

      Pages: 2565-2575

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor2007

    • Author(s)
      Tsuda, M., Ishii,S., Masuda,T., Hasegawa,S., K., Nakamura, Nagata, K., Yamashita,T., Fume,H., Tozaki-Saitoh,H., Yoshimura,M., Koizumi, S., Shimizu, K., Inoue T
    • Journal Title

      Journal of Neurochemistry 102(5)

      Pages: 1658-1668

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Electrophysiological analysis of plastic changes in nociceptive transmission2007

    • Author(s)
      Fume,H., Yoshimura M.
    • Journal Title

      Pain Clinic 28(1)

      Pages: 93-105

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The role of GABAB receptor in spinal nociceptive transmission2007

    • Author(s)
      Takeshima, K., Fume, H., Yoshimura M.
    • Journal Title

      pain Research 22

      Pages: 33-41

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Function of spinal GABA receptor and its modulation.2007

    • Author(s)
      Yoshimura, M., Fume, H., Takazawa, T., Kohno, T., Takeshima, K
    • Journal Title

      Masui 56

      Pages: S141-S151

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Recent insights into mechanisms for analgesic effect by calcitonin.2007

    • Author(s)
      Ito, A., Fume, H., Yoshimura, M
    • Journal Title

      Nippon Rinsho 65(S9)

      Pages: 386-390

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] In vivo patch-clamp technique.2007

    • Author(s)
      H., Fume, T., Katafuchi, M., Yoshimura
    • Journal Title

      Patch-Clamp Analysis : advanced techniques, Second Edition. Ed.(W., Walz)(Humana Press Inc., Totowa)

      Pages: 229-251

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Direct excitation of deep dorsal horn neurones in the rat spinal cord by the activation of postsynaptic P2X receptors2006

    • Author(s)
      Shiokawa H., et. al.
    • Journal Title

      Journal of Physiology(London) 573(Pt3)

      Pages: 753-763

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Tonic inhibitory role of alpha4beta2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the apinal cord in mice2006

    • Author(s)
      Rashid MH., et. al.
    • Journal Title

      Pain 125(1-2)

      Pages: 125-135

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Mechanisms for the Anti-nociceptive actions of the descending noradrenergic and serotonergic systems in the spinal cord2006

    • Author(s)
      Yoshimura M., et. al.
    • Journal Title

      Journal of Pharmacological Sciences 101

      Pages: 107-117

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Direct excitation of deep dorsal horn neurones in the rat spinal cord by the activation of postsynaptic P2X receptors2006

    • Author(s)
      Shiokawa,H., Nakatsuka, T., Furue, H., Tsuda,M., Katafuchi,T., Inoue, K., Yoshimura M.
    • Journal Title

      Journal of Physiology(London) 573(Pt3)

      Pages: 753-763

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Tonic inhibitory role of alpha4beta2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the spinal cord in mice2006

    • Author(s)
      Rashid, MH., Furue,H., Yoshimura, M., UedaH
    • Journal Title

      Pain 125(1-2)

      Pages: 125-135

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Mechanisms for the Anti-nociceptive actions of the descending noradrenergic and serotonergic systems in the spinal cord2006

    • Author(s)
      Yoshimura,M., FurueH
    • Journal Title

      Journal Pharmacological Sciences 101

      Pages: 107-117

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Increased mechanical synaptic inputs to the rat spinal dorsal horn in vivo2008

    • Author(s)
      Furue H., et. al.
    • Organizer
      The 85th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo,Japan
    • Year and Date
      20080325-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Selective modulation of excitatory synaptic transmission in excitatory interneurons in the adult rat spinal dorsal horn through TRPA1 agonist-sensitive C fibres2008

    • Author(s)
      Uta D., et. al.
    • Organizer
      The 85th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo,Japan
    • Year and Date
      20080325-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] In vivo intracellular recording analysis of itch signal transduction in rat dorsal root ganglion cells2008

    • Author(s)
      Hachisuka J., et. al.
    • Organizer
      The 85th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo,Japan
    • Year and Date
      20080325-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Increased mechanical synaptic inputs o the rat spinal dorsal horn in vivo following inflammation.2008

    • Author(s)
      H., Fume, J., Hachisuka, M., Yoshimura
    • Organizer
      The 85th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20080325-27
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Selective modulation of excitatory synaptic transmission in excitatory intemeurons in the adult rat spinal dorsal horn through TRPA1 agonist-sensitive C fibres.2008

    • Author(s)
      D., Uta, H., Fume, M., Yoshimura
    • Organizer
      The 85th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20080325-27
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] In vivo intracellular recording analysis of itch signal transduction in rat dorsal root ganglion cells.2008

    • Author(s)
      J., Hachisuka, H., Fume, M., Fume, M., Yoshimura
    • Organizer
      The 85th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20080325-27
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Central sensitization induced switching of subunit in AMPA receptor following inflammatory pain2007

    • Author(s)
      Katano T., et. al.
    • Organizer
      The 30th Annual Meeting of the Molecular Biology Society of Japan and The 80th Annual Meeting of the Japanese Biochemical Society
    • Place of Presentation
      Yokohama,Japan
    • Year and Date
      20071211-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Central sensitization induced by switching of subunit in AMPA receptor following inflammatory pain.2007

    • Author(s)
      T., Katano, H., Fume, M., Tagatani, E., Ashitaka, M., Yoshimura, S., Ito
    • Organizer
      The 30th Annual Meeting of the Molecular Biology Society of Japan and The 80th Annual Meeting of the Japanese Biochemical Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      20071211-15
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Functional loss of synaptic inputs to spinal superficial dorsal horn neurons through cold-sensitive afferent fibers in cadherin-8 deficient mice2007

    • Author(s)
      Furue H., et. al.
    • Organizer
      The 7th Japan-Korea Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscles
    • Place of Presentation
      Sendai,Japan
    • Year and Date
      20071208-10
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Functional loss of synaptic inputs to spinal superficial dorsal horn neurons through cold-sensitive afferent fibers in cadherin-8 deficient mice.2007

    • Author(s)
      H., Fume, M., Yoshimura
    • Organizer
      The 7th Japan-Korea Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscles
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      20071208-10
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Modulation of sensory inputs from inflamed region to the primary sensory cortex2007

    • Author(s)
      Yoshimura M., et. al.
    • Organizer
      The 2nd International Symposium on Design of Artificial Environments
    • Place of Presentation
      Fukuoka,Japan
    • Year and Date
      20071129-1201
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Modulation of sensory inputs from inflamed region to the primary sensory cortex.2007

    • Author(s)
      M., Yoshimura, K., Koga, H., Fume
    • Organizer
      The 2nd International Symposium on Design of Artificial Environments
    • Place of Presentation
      Fnknnka Janan
    • Year and Date
      20071129-1201
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] In vivo and slice patch-clamp analyses of plastic changes indescending inhibition of spinal noxious mechanical synaptic transmission in ovariectomized rats2007

    • Author(s)
      Furue H., et. al.
    • Organizer
      The 37th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego,USA
    • Year and Date
      20071103-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Increased noxious mechanical synaptic inputs to the rat spinal dorsal horn from A delta and C fibers:in vivo patch-clamp and intracellular recordings from spinal and dorsal root ganglion neurons2007

    • Author(s)
      Hachisuka J., et. al.
    • Organizer
      The 37th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego,USA
    • Year and Date
      20071103-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Electrophysiological and morphological analyzes of excitatory effect of TRPAl agonists on synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord2007

    • Author(s)
      Uta D., et. al.
    • Organizer
      The 37th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego,USA
    • Year and Date
      20071103-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Cortical membrane potential fluctuations may be modified by thalamocortical inputs in rat barrel cortex in vivo2007

    • Author(s)
      Mizuno M., et. al.
    • Organizer
      The 37th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego,USA
    • Year and Date
      20071103-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] In vivo and slice patch-clamp analyses of plastic changes in descending inhibition of spinal noxious mechanical synaptic transmission in ovariectomized rats.2007

    • Author(s)
      H., Fume, Y., Omori, A., Ito, Y., Kuraishi, M., Yoshimura
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20071103-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Increased noxious mechanical synaptic inputs to the rat spinal dorsal horn from A delta and C fibers : in vivo patch-clamp and intracellular recordings from spinal and dorsal soot ganglion neurons.2007

    • Author(s)
      J., Hachisuka, H., Fume, M., Yoshimura
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20071103-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Electrophysiological and morphological analyzes of excitatory effect of TRPA1 agonists on synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord.2007

    • Author(s)
      D., Uta, MH., Rashid, H., Fume, R., Hisamitsu, M., Yoshimura
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20071103-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Cortical membrane potential fluctuations may be modified by thalamocortical inputs in rat barrel cortex in vivo.2007

    • Author(s)
      M., Mizuno, A., Doi, T., Yasaka, H., Fume, S., Aou, M., Yoshimura
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20071103-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Behavioral and electrophysiological analyses of spinal nociceptive transmission in a murine model of cancer-induced bone pain2007

    • Author(s)
      Yanagisawa Y., et. al.
    • Organizer
      The 22nd Annual Research Meeting of the Japanese Orthopaedic Association
    • Place of Presentation
      Shizuoka,Japan
    • Year and Date
      20071025-26
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Behavioral and electrophysiological analyses of spinal nociceptive transmission in a murine model of cancer-induced bone pain.2007

    • Author(s)
      Y., Yanagisawa, H., Fume, T., Kawamata, A., Namiki, Y., Iwamoto, M., Yoshimura
    • Organizer
      The 22nd Annual Research Meeting of the Japanese Orthopaedic Association
    • Place of Presentation
      Shizuoka, Japan
    • Year and Date
      20071025-26
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Impairment of afferent synaptic inputs for mechanical and cold sensation to substantia gelatinosa neurons of the rat spinal dorsal horn through cadherin-8 expressing synaptic glomeruli2007

    • Author(s)
      Furue H., et. al.
    • Organizer
      The 30th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama,Japan
    • Year and Date
      20070910-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Plastic modification of TRP channel activities in the spinal dorsal horn following peripheral nerve injury2007

    • Author(s)
      Yoshimura M., et. al.
    • Organizer
      The 30th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama,Japan
    • Year and Date
      20070910-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] In vivo patch-clamp analysis of plastic changs in descending serotonergic inhibition of noxious mechanical transmission to substantia gelatinosa neurons through 5-HTIA receptors in ovariectomized rats2007

    • Author(s)
      Omori Y., et. al.
    • Organizer
      The 30th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama,Japan
    • Year and Date
      20070910-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Patch-clamp analysis of membrane propreties of bursting neurons in the young adult rat ventral horn in vitro2007

    • Author(s)
      Hisamitsu R., et. al.
    • Organizer
      The 30th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama,Japan
    • Year and Date
      20070910-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] In vivo patch clamp analysis of synaptic responses evoked in primary somatosensory cortex in inflamed rats2007

    • Author(s)
      Koga K., et. al.
    • Organizer
      The 30th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama,Japan
    • Year and Date
      20070910-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Impairment of afferent synaptic inputs for mechanical and cold sensation to substantia gelatinosa neurons of the rat spinal dorsal horn through cadherin-8 expressing synaptic glomeruli.2007

    • Author(s)
      H., Fume, SC., Suzuki, K., Koga, M., Nohmi, M., Takeichi, M., Yoshimura
    • Organizer
      The 30th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      20070910-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Plastic modification of TRP channel activities in the spinal dorsal horn following peripheral nerve injury.2007

    • Author(s)
      M., Yoshimura, H., Fume
    • Organizer
      The 30th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      20070910-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] In vivo patch-clamp analysis of plastic changes in descending serotonergic inhibition of noxious mechanical transmission to substantia gelatinosa neurons through 5-HT1A receptors in ovariectomized rats.2007

    • Author(s)
      Y., Omori, H., Fume, A., Ito, Y., Kuraishi, M., Yoshimura
    • Organizer
      The 30th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      20070910-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Patch-clamp analysis of membrane properties of bursting neurons in the young adult rat ventral horn in vitro.2007

    • Author(s)
      R., Hisamitsu, H., Fume, M., Yoshimura
    • Organizer
      The 30th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      20070910-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] In vivo patch clamp analysis of synaptic responses evoked in primary somatosensory cortex in inflamed rats.2007

    • Author(s)
      K., Koga, H., Shiokawa, M., Mizuno, A., Doi, H., Takase-Mizuguchi, H., Fume, M., Yoshimura
    • Organizer
      The 30th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      20070910-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Analogy of A-beta afferents termination in pathological conditions with immature state2007

    • Author(s)
      Yoshimura M., et. al.
    • Organizer
      Second International Congress on Neuropathic Pain
    • Place of Presentation
      Berlin,Germany
    • Year and Date
      20070607-10
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Modification of bursting activities in somatosensory cortex in inflamed-rats in vivo2007

    • Author(s)
      Koga K., et. al.
    • Organizer
      Second International Congress on Neuropathic Pain
    • Place of Presentation
      Berlin,Germany
    • Year and Date
      20070607-10
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Analogy of A-beta afferents termination in pathological conditions with immature state.2007

    • Author(s)
      M., Yoshimura, T., Nakatsuka, H., Fume
    • Organizer
      Second International Congress on Neuropathic Pain
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      20070607-10
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Modification of bursting activities in somatosensory cortex in inflamed -rats in vivo.2007

    • Author(s)
      K., Koga, H., Shiokawa, M., Mizuno, A., Doi, H., Takase-Mizuguchi, H., Fume, M., Yoshimura
    • Organizer
      Second International Congress on Neuropathic Pain
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      20070607-10
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Functional role pf GABA receptor and its modification in the spinal dorsal horn2007

    • Author(s)
      Yoshimura M., et. al.
    • Organizer
      The 54th Annual Meeting of Japanese Society of Anesthesiologists
    • Place of Presentation
      Sapporo,Japan
    • Year and Date
      20070531-0602
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Functional role pf GABA receptor and its modification in the spinal dorsal horn.2007

    • Author(s)
      M., Yoshimura, T., Takazawa, T., Kohno, H., Fume, K., Koga
    • Organizer
      The 54th Annual Meeting of Japanese Society of Anesthesiologists
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      20070531-0602
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Reduction of menthol-sensitive afferent inputs to superficial dorsa neurons in knockout mice of cadherin-82007

    • Author(s)
      Furue H., et. al.
    • Organizer
      The 84th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Osaka,Japan
    • Year and Date
      20070320-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Analogy of A-beta afferent sprouting in inflamed rats with sensory circuit in developing spinal dorsal horn2007

    • Author(s)
      Yoshimura M., et. al.
    • Organizer
      The 84th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Osaka,Japan
    • Year and Date
      20070320-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Excitatory effect of TRPAl agonists on noxious transmission in substantia gelatinosa neurons of the rat spinal cord2007

    • Author(s)
      Uta D., et. al.
    • Organizer
      The 84th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Osaka,Japan
    • Year and Date
      20070320-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Reduction of menthol-sensitive afferent inputs to superficial dorsa neurons in knockout mice of cadherin-8.2007

    • Author(s)
      H., Fume, S., Suzuki, K., Koga, Y., Shimazaki, M., Nohmi, M., Takeichi, M., Yoshimura
    • Organizer
      The 84th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      20070320-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Analogy of A-beta afferent sprouting in inflamed rats with sensory circuit in developing spinal dorsal horn.2007

    • Author(s)
      M., Yoshimura, H., Fume, S., Matayoshi, T., Nakatsuka, T., Katafuchi
    • Organizer
      The 84th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      20070320-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Excitatory effect of TRPAI agonists on noxious transmission in substantia gelatinosa neurons of the rat spinal cord.2007

    • Author(s)
      D., Uta, MH., Rashid, H., Fume, M., Yoshimura
    • Organizer
      The 84th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      20070320-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] In vivo intracellular recording analysis of action potentials elicited by 5-HT-induced itch stimuli in rat dorsal root ganglion neurons2007

    • Author(s)
      Hachisuka J., et. al.
    • Organizer
      17th International Symposium of Itch
    • Place of Presentation
      Osaka,Japan
    • Year and Date
      2007-09-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] In vivo intracellular recording analysis of action potentials elicited by 5-HT-induced itch stimuli in rat dorsal root ganglion neurons2007

    • Author(s)
      J., Hachisuka, H., Fume, M., Fume, M., Yoshimura
    • Organizer
      17th International Symposium of Itch
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2007-09-15
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Activation of TRPAl reduces C afferent-evoked excitatory synaptic transmission but enhances the miniature release in substantia gelatinosa of the adult rat spinal cord2007

    • Author(s)
      Uta D., et. al.
    • Organizer
      The 29th Annual Meeting of JASP
    • Place of Presentation
      Yokohama,Japan
    • Year and Date
      2007-07-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Electrophysiological analysis of effects of Neurotropin on serotonergic neurons in the Nucleus Raphe Magnus2007

    • Author(s)
      Okai H., et. al.
    • Organizer
      The 29th Annual Meeting of JASP
    • Place of Presentation
      Yokohama,Japan
    • Year and Date
      2007-07-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Activation of TRPA1 reduces C afferent-evoked excitatory synaptic transmission but enhances the miniature release in substantia gelatinosa of the adult rat spinal cord.2007

    • Author(s)
      D., Uta, MH., Rashid, H., Fume, M., Yoshimura
    • Organizer
      The 29th Annual Meeting of JASP
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2007-07-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Electrophysiological analysis of effects of Neurotropin on serotonergic neurons in the Nucleus Raphe Magnus.2007

    • Author(s)
      H., Okai, H., Fume, M., Yoshimura
    • Organizer
      The 29th Annual Meeting of JASP
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2007-07-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Functional loss of synaptic inputs to substantia gelatinosa neurons in the spinal cord through menthol-sensitive afferent fibers in cadherin-8 deficient mice2006

    • Author(s)
      Furue H., et. al.
    • Organizer
      The 36th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Atlanta,USA
    • Year and Date
      20061014-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Cadherin-8 regulates activities of the first relay synapse for cool sensation2006

    • Author(s)
      Suzuki S., et. al.
    • Organizer
      The 36th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Atlanta,USA
    • Year and Date
      20061014-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Actions of agonists for the noxious cold ion channel TRPA1 in synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord2006

    • Author(s)
      Uta D., et. al.
    • Organizer
      The 36th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Atlanta,USA
    • Year and Date
      20061014-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] In vivo patch-clamp analysis of GABA_B receptor-mediated inhibitory effects on noxious and innocuous mechanical synaptic transmission in substantia gelarinosa neurons of the rat spinal cord2006

    • Author(s)
      Takeshima K., et. al.
    • Organizer
      The 36th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Atlanta,USA
    • Year and Date
      20061014-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Whole-cell patch-clamp analusis of firing patterns of ventral horn neurons in young adult rat in vitro2006

    • Author(s)
      Hisamitsu R., et. al.
    • Organizer
      The 36th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Atlanta,USA
    • Year and Date
      20061014-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Functional loss of synaptic inputs to substantia gelatinosa neurons in the spinal cord through menthol-sensitive afferent fibers in cadherin-8 deficient mice.2006

    • Author(s)
      Fume, H., Suzuki, S., Koga, K., Jiang, N., Nohmi, M., Takeichi, M., Yoshimura, M.
    • Organizer
      The 36th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      20061014-18
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Cadherin-8 regulates activities of the first relay synapse for cool sensation.2006

    • Author(s)
      Suzuki, H., Fume, H., Koga, K., Jiang, N., Nohmi, M., Yoshimura, M., Takeichi, M
    • Organizer
      The 36th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      20061014-18
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Actions of agonists for the noxious cold ion channel TRPAI in synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord.2006

    • Author(s)
      Uta, D., Rashid, MH., Furue, H., Katafuchi, T., Hisamitsu, R., Shimada, H., Yoshimura, M
    • Organizer
      The 36th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      20061014-18
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] In vivo patch-clamp analysis of GABAB receptor-mediated inhibitory effects on noxious and innocuous mechanical synaptic transmission in' substantia gelatinosa neurons of the rat spinal cord.2006

    • Author(s)
      Takeshima, K., Fume, H., Yoshimura, M
    • Organizer
      The 36th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      20061014-18
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Whole-cell patch-clamp analysis of firing patterns of ventral horn neurons in young adult rat in vitro.2006

    • Author(s)
      Hisamitsu, R., Shimada, H., Uta, D., Take, S., Fume, H., Yoshimura, M
    • Organizer
      The 36th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      20061014-18
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Actions of serotonin on nociceptive transmission in the substantia gelatinosa of the rat spinal cord2006

    • Author(s)
      Abe K., et. al.
    • Organizer
      The 29th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kobe,Japan
    • Year and Date
      20060719-21
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Actions of local anesthetics on primary afferent synaptic transmission to the substantia gelatinosa of the rat spinal cord2006

    • Author(s)
      Uta D., et. al.
    • Organizer
      The 29th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kobe,Japan
    • Year and Date
      20060719-21
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Actions of serotonin on nociceptive transmission in the substantia gelatinosa of the rat spinla cord.2006

    • Author(s)
      Abe, K., Fume, H., Koga, K., Kato, G., Yasaka, T., Tamae, A., Katafuchi, T., Yoshimura, M
    • Organizer
      The 29th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      20060719-21
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Actions of local anesthetics on primary afferent synaptic transmission to the substantia gelatinosa of the rat spinal cord.2006

    • Author(s)
      Uta, D., Fume, H., Rashid, MH., Yoshimura, M
    • Organizer
      The 29th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      20060719-21
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] In vivo patch-clamp analysis of effects of bacrofen on noxious and innocuous synaptic transmission in substantia gelarinosa neurons of the rat spinal cord2006

    • Author(s)
      Takeshima K., et. al.
    • Organizer
      The 28th Annual Meeting of JASP
    • Place of Presentation
      Kobe,Japan
    • Year and Date
      20060714-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Physiological properties of substantia gelatinosa neurons in neonatal rats by in vivo patch-clamp analysis2006

    • Author(s)
      Kawamata M., et. al.
    • Organizer
      The 28th Annual Meeting of JASP
    • Place of Presentation
      Kobe,Japan
    • Year and Date
      20060714-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] In vivo patch-clamp analysis of effects of bacrofen on noxious and innocuous synaptic transmission in substantia gelatinosa neurons of the rat spinal cord.2006

    • Author(s)
      Takeshima, K., Fume, H., Yoshimura, M
    • Organizer
      The 28th Annual Meeting of JASP
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      20060714-15
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Physiological properties of substantia gelatinosa neurons in neonatal rats by in vivo patch-clamp analysis.2006

    • Author(s)
      Kawamata, M., Sugino, S., Kiya, T., Fume, H., Yoshimura, M., Namiki, A
    • Organizer
      The 28th Annual Meeting of JASP
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      20060714-15
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Patch-Clamp analysis:advanced techniques2007

    • Author(s)
      Furue H, et. al.
    • Total Pages
      475
    • Publisher
      Humana Press
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-02-04  

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