2009 Fiscal Year Final Research Report
Study for reciprocal double effects of nociceptin on spinal pain transmission.
| Project/Area Number |
18613015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
WATANABE Chizuko Tohoku Pharmaceutical University, 薬学部, 助教 (90296020)
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| Co-Investigator(Kenkyū-buntansha) |
櫻田 忍 東北薬科大学, 薬学部, 教授 (30075816)
溝口 広一 東北薬科大学, 薬学部, 准教授 (30360069)
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| Project Period (FY) |
2006 – 2009
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| Keywords | ノシセプチン / 疼痛伝達 / 鎮痛作用 / 神経制御 / 脊髄 |
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| Research Abstract |
The involvement of various neurotransmitters on spinal pain transmission was investigated in this project. As the results, it was found that nociceptin, hemokinin, histamine, endogenous cannabinoid, endogenous polyamine, as well as substance P and glutamate, participated on spinal pain transmission, and the spinal pain transmission was regulated by the mutual control of these neurotransmitter-containing neurons. In addition, it was also found that the supersensitivity of these neurotransmitters was occurred at the stage of the neuropathic pain to increase the pain sensation.
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Research Products
(19 results)
