Measurements of cellular microstructure and function using magnetic resonance

2008 Fiscal Year Final Research Report

• Project/Area Number: 18680037
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: The University of Tokyo
• Principal Investigator: SEKINO Masaki The University of Tokyo, 大学院・新領域創成科学研究科, 助教授 (20401036)
• Project Period (FY): 2006 – 2008
• Keywords: 生物・生体工学 / 磁気共鳴 / 医用画像 / イメージング / 細胞膜

Research Abstract

本研究では,生体に含まれる水の拡散の磁気共鳴イメージング(MRI)を通じて,細胞の大きさなどの微視的構造と,それに深く関わる生体組織の導電率や細胞膜透過率などを推定する手法を提案した.シミュレーションや動物のMRI 測定などを通じて,提案手法の有用性を示した.

Research Products

• [Journal Article] Estimation of cell membrane permeability and intracellular diffusion coefficient of the human gray matter (2009)
  • Author(s): T. Imae, H. Shinohara, M. Sekino, S. Ueno, H. Ohsaki, K. Mima, and K. Ohtomo
  • Journal Title: Magnetic Resonance in Medical Sciences vol.8, Pages: 1-7
  • Peer Reviewed
• [Journal Article] Imaging of electric permittivity and conductivity using MRI (2008)
  • Author(s): M. Sekino, S. Tatara, and H. Ohsaki
  • Journal Title: IEEE Transactions on Magnetics vol.44 Pages: 4460-4463
  • Peer Reviewed
• [Journal Article] Discriminative detection of extracellular and intracellular sodiums in nerve fibers by magnetic resonance spectroscopy (2008)
  • Author(s): S. Yamaguchi-Sekino, H. Tatsuoka, M. Sekino, H. Ohsaki, Y. Abe, and S. Ueno
  • Journal Title: IEEE Transactions on Magnetics vol.44 Pages: 4500-4502
  • Peer Reviewed
• [Journal Article] Minimization of Computational Errors in Diffusion Simulation of Nuclear Magnetization (2008)
  • Author(s): T. Imae, H. Shinohara, M. Sekino, H. Ohsaki, S. Ueno, K. Mima, and K. Ootomo
  • Journal Title: IEEE Transactions on Magnetics vol.44 Pages: 4496-4499
  • Peer Reviewed
• [Journal Article] FDTD simulations of RF electromagnetic fields and signal inhomogeneities in ultrahigh-field MRI systems (2008)
  • Author(s): M. Sekino, D. Kim, and H. Ohsaki
  • Journal Title: Journal of Applied Physics vol.103 Pages: 07A318
  • Peer Reviewed
• [Journal Article] Estimation of cell membrane permeability of the rat brain using diffusion magnetic resonance imaging (2008)
  • Author(s): T. Imae, H. Shinohara, M. Sekino, S. Ueno, H. Ohsaki, K. Mima, and K. Ootomo
  • Journal Title: Journal of Applied Physics vol.103 Pages: 07A311
  • Peer Reviewed
• [Journal Article] 拡散MRI を用いたラットの細胞膜透過率評価 (2008)
  • Author(s): 今江禄一, 篠原広行, 関野正樹, 上野照剛, 大崎博之, 美馬和男, 大友邦
  • Journal Title: Journal of the Magnetics Society of Japan vol.32 Pages: 491-494
  • Peer Reviewed
• [Journal Article] MRIを用いた誘電率と導電率のイメージング (2008)
  • Author(s): 多田羅智史, 関野正樹, 栗林秀人, 大崎博之
  • Journal Title: 日本AEM学会誌 vol.16 Pages: 20-26
  • Peer Reviewed
• [Journal Article] 最新MRI技術 (2008)
  • Author(s): 上野照剛, 関野正樹, 大崎博之
  • Journal Title: 映像情報メディア学会誌 vol.62 Pages: 494-499
  • Peer Reviewed
• [Journal Article] q-space MRIによる再生軟骨および関節軟骨の組織評価法 (2008)
  • Author(s): 宮田昌悟, 関野正樹, 大崎博之, 牛田多加志
  • Journal Title: 日本磁気共鳴医学会雑誌 vol.28 Pages: 92-94
  • Peer Reviewed
• [Journal Article] Iron hydroxide nanoparticles coated with poly(ethylene glycol)-poly(aspartic acid) block copolymer as novel magnetic resonance contrast agents for in vivo cancer imaging (2007)
  • Author(s): M. Kumagai, Y. Imai, T. Nakamura, Y. Yamasaki, M. Sekino, S. Ueno, K. Hanaoka, K. Kikuchi, T. Nagano, E. Kaneko, K. Shimokado, and K. Kataoka
  • Journal Title: Colloids and Surfaces B: Biointerfaces vol.56 Pages: 174-181
  • Peer Reviewed
• [Journal Article] Magnetic resonance imaging of electric properties in living bodies (2007)
  • Author(s): M. Sekino, and S. Ueno
  • Journal Title: Biocybernetics and Biomedical Engineering vol.27 Pages: 175-182
  • Peer Reviewed
• [Journal Article] MRIにおける画素サイズより小さい試料の計測と定量化誤差 (2007)
  • Author(s): 関野正樹, 上野照剛, 大崎博之
  • Journal Title: 日本AEM学会誌 vol.15 Pages: 76-82
  • Peer Reviewed
• [Journal Article] 生体組織の機械的変形が組織内水分子の拡散に与える効果 (2007)
  • Author(s): 田中堅一郎, 関野正樹, 今江禄一, 上野照剛, 大崎博之, 美馬和男
  • Journal Title: 日本応用磁気学会誌 vol.31 Pages: 283-287
  • Peer Reviewed
• [Journal Article] 生体内水分子の磁化拡散シミュレーションにおける離散化誤差を最小とする条件 (2007)
  • Author(s): 今江禄一, 篠原廣行, 関野正樹, 上野照剛, 大崎博之, 美馬和男, 大友邦
  • Journal Title: 日本応用磁気学会誌 vol.31 Pages: 279-282
  • Peer Reviewed
• [Journal Article] Retrograde cerebral perfusion with intermittent pressure augmentation provides adequate neuroprotection : diffusion- and perfusion-weighted magnetic resonance imaging study in an experimental canine model (2006)
  • Author(s): M. Kawata, M. Sekino, S. Takamoto, S. Ueno, S. Yamaguchi, K. Kitahori, H. Tsukihara, Y. Suematsu, M. Ono, N. Motomura, T. Morota, and A. Murakami
  • Journal Title: The Journal of Thoracic and Cardiovascular Surgery vol.132 Pages: 933-940
  • Peer Reviewed
• [Journal Article] Toward detection of transient changes in magnetic resonance signal intensity arising from neuronal electrical activities
  • Author(s): M. Sekino, H. Ohsaki, S. Yamaguchi-Sekino, and S. Ueno
  • Journal Title: IEEE Transactions on Magnetics (掲載確定)
  • Peer Reviewed
• [Journal Article] Low-frequency conductivity tensor of rat brain tissues inferred from diffusion MRI
  • Author(s): M. Sekino, H. Ohsaki, S. Yamaguchi-Sekino, N. Iriguchi, and S. Ueno
  • Journal Title: Bioelectromagnetics (掲載確定)
  • Peer Reviewed
• [Presentation] Detection of transient changes in magnetic resonance signal intensity arising from neuronal electrical activities (2009)
  • Author(s): M. Sekino, H. Ohsaki, S. Yamaguchi-Sekino, and S. Ueno
  • Organizer: IEEE International Magnetics Conference
  • Place of Presentation: Sacramento, USA
  • Year and Date: 2009-05-06
• [Presentation] Multidirectional RF coils for MRI (2009)
  • Author(s): S. Takemoto, M. Migita, N. Mizuuchi, K. Maruyama, T. Moroi, T. Sueyoshi, M. Sekino, and N. Iriguchi
  • Organizer: 2009 IEEE/ICME International Conference on Complex Medical Engineering
  • Place of Presentation: Tempe, USA
  • Year and Date: 2009-04-09
• [Presentation] Detection of neuronal electrical activities using MRI (2008)
  • Author(s): M. Sekino, S. Yamaguchi-Sekino, H. Ohsaki, and S. Ueno
  • Organizer: International Conference on Biomagnetism
  • Place of Presentation: Sapporo
  • Year and Date: 2008-08-27
• [Presentation] Recent advances in impedance MRI (2008)
  • Author(s): S. Ueno, and M. Sekino
  • Organizer: URSI General Assembly
  • Place of Presentation: Chicago, USA
  • Year and Date: 2008-08-14
• [Presentation] Recent advances in electric current MRI (2008)
  • Author(s): M. Sekino, S. Yamaguchi-Sekino, H. Ohsaki, and S. Ueno
  • Organizer: URSI General Assembly
  • Place of Presentation: Chicago, USA
  • Year and Date: 2008-08-14
• [Presentation] RF and imaging technology for high field MRI (2008)
  • Author(s): M. Sekino, S. Yamaguchi-Sekino, S. Ueno, and H. Ohsaki
  • Organizer: NeuroSpin/CEA-University of Tokyo Workshop
  • Place of Presentation: Saclay, France
  • Year and Date: 2008-05-21
• [Presentation] Discriminative detection of extracellular and intracellular sodiums in nerve fibers by magnetic resonance spectroscopy (2008)
  • Author(s): S. Yamaguchi-Sekino, H. Tatsuoka, M. Sekino, H. Ohsaki, Y. Abe, and S. Ueno
  • Organizer: IEEE International Magnetics Conference
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2008-05-08
• [Presentation] Minimization of computational errors in diffusion simulation of nuclear magnetization (2008)
  • Author(s): T. Imae, H. Shinohara, M. Sekino, H. Ohsaki, S. Ueno, K. Mima, and K. Ootomo
  • Organizer: IEEE International Magnetics Conference
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2008-05-08
• [Presentation] Imaging of electric permittivity and conductivity using MRI (2008)
  • Author(s): M. Sekino, S. Tatara, and H. Ohsaki
  • Organizer: IEEE International Magnetics Conference
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2008-05-06
• [Presentation] Magnetic resonance imaging of neuronal electrical activities in the rat brain (2007)
  • Author(s): M. Sekino, S. Ueno, and H. Ohsaki
  • Organizer: 52nd Magnetism and Magnetic Materials Conference
  • Place of Presentation: Tampa, USA
  • Year and Date: 2007-11-08
• [Presentation] FDTD simulations of RF magnetic fields and signal inhomogeneities in high-field MRI systems (2007)
  • Author(s): M. Sekino, D. Kim, and H. Ohsaki
  • Organizer: 52nd Magnetism and Magnetic Materials Conference
  • Place of Presentation: Tampa, USA
  • Year and Date: 2007-11-08
• [Presentation] Estimation of cell membrane permeability of the rat brain using diffusion magnetic resonance imaging (2007)
  • Author(s): T. Imae, H. Shinohara, M. Sekino, S. Ueno, H. Ohsaki, K. Mima, and K. Ootomo
  • Organizer: 52nd Magnetism and Magnetic Materials Conference
  • Place of Presentation: Tampa, USA
  • Year and Date: 2007-11-08
• [Presentation] RF absorption in the human head in ultrahigh-field magnetic resonance imaging systems of up to 11.7 T (2007)
  • Author(s): M. Sekino, D. Kim, S. Ueno, and H. Ohsaki
  • Organizer: 29th Annual Meeting of the Bioelectromagnetics Society
  • Place of Presentation: Kanazawa, Japan
  • Year and Date: 2007-06-12
• [Presentation] Optimal computational errors in diffusion simulation of nuclear magnetization in water molecules (2007)
  • Author(s): T. Imae, H. Shinohara, M. Sekino, S. Ueno, H. Ohsaki, K. Mima, and K. Ootomo
  • Organizer: 29th Annual Meeting of the Bioelectromagnetics Society
  • Place of Presentation: Kanazawa, Japan
  • Year and Date: 2007-06-11
• [Presentation] Changes in diffusion properties of biological tissues associated with mechanical strain (2007)
  • Author(s): K. Tanaka, T. Imae, M. Sekino, S. Ueno, H. Ohsaki, and K. Mima
  • Organizer: 29th Annual Meeting of the Bioelectromagnetics Society
  • Place of Presentation: Kanazawa, Japan
  • Year and Date: 2007-06-11
• [Presentation] FDTD simulations of RF inhomogeneities in ultrahigh-field MRI systems of up to 11.7 T (2007)
  • Author(s): M. Sekino, S. Ueno, and H. Ohsaki
  • Organizer: ISMRM-ESMRMB Joint Annual Meeting
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2007-05-21
• [Presentation] Magnetic resonance imaging of water diffusion and cell microstructures in biological tissues (2007)
  • Author(s): M. Sekino, S. Ueno, and H. Ohsaki
  • Organizer: Seoul National University - University of Tokyo Joint Seminar on Electrical Engineering
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 2007-02-28