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2008 Fiscal Year Final Research Report

Statistical Analysis of causal relationship between the genes from gene expression data.

Research Project

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Project/Area Number 18681031
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field 基礎ゲノム科学
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

ABURATANI Sachiyo  National Institute of Advanced Industrial Science and Technology, 生命情報工学研究センター, 研究員 (10361627)

Project Period (FY) 2006 – 2008
Keywords生体生命情報学 / マイクロアレイ / 発現制御 / 遺伝子ネットワーク / グラフィカル連鎖モデル
Research Abstract

本研究では、発現プロファイルデータに既知の生物学的知見を加えて遺伝子間の因果性を推定する統計的手法を開発し、関連の有無や強弱に加え遺伝子間の因果性の解明を行った。また、開発した手法をウェブツールとして広く公開した。本研究で開発した手法は、数値データに既知の生物学的知見を加えた統計的手法であり、この手法を用いることによって、遺伝子間の発現相互作用について関連性の有無や強弱に加え遺伝子間の因果性の解明までを行うことが可能になった。

  • Research Products

    (17 results)

All 2009 2008 2007 2006 Other

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (4 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Statistical Analysis of the Relationship between LexA-Regulated Genes from Expression Profiles2008

    • Author(s)
      Aburatani, S. and Horimoto, K.
    • Journal Title

      Res. Commun. Biochem. Cell Mol. Biol. Vol.12, NOS.1&2

      Pages: 119-135

    • Peer Reviewed
  • [Journal Article] Integer Programming-based Approach to Allocation of Reporter Genes for Cell Array Analysis2008

    • Author(s)
      Hayashida, M., Sun, F., Aburatani, S., Horimoto, K. and Akutsu, T.
    • Journal Title

      Int. J.Bioinformatics Research and Applications Vol.4(4)

      Pages: 385-399

    • Peer Reviewed
  • [Journal Article] Network evaluation from the consistency of the graph structure with the measured data2008

    • Author(s)
      Saito, S., Aburatani, S. and Horimoto, K.
    • Journal Title

      BMC Systems Biology Vol.2:84

      Pages: 1-14

    • Peer Reviewed
  • [Journal Article] Gene systems network inferred from expression profiles in hepatocellular carcinogenesis by graphical Gaussian model2007

    • Author(s)
      Aburatani, S., Sun, F., Saito, S., Honda, M., Kaneko, S. and Horimoto, K.
    • Journal Title

      EURASIP J. Bioinfo. Systems Biol. Vol.47214

      Pages: 1-11

    • Peer Reviewed
  • [Journal Article] Integer Programming-based Approach to Allocation of Reporter Genes for Cell Array Analysis2007

    • Author(s)
      Hayashida, M., Sun, F., Aburatani, S., Horimoto, K. and Akutsu, T.
    • Journal Title

      Proceedings of OSB2007

      Pages: 21-28

    • Peer Reviewed
  • [Journal Article] ASIAN : A Network Inference Web Server for Biologists2007

    • Author(s)
      Aburatani, S.
    • Journal Title

      Proceedings of the 11th World Multiconference on Systemics, Cybernetics and Informatics Vol.4

      Pages: 1-6

    • Peer Reviewed
  • [Journal Article] Inference of Complex Regulatory Network for the Cell Cycle System in Saccharomyces cerevisiae2007

    • Author(s)
      Aburatani, S.
    • Journal Title

      Algebraic Biology 2007 Lecture Notes in Computer Science

      Pages: 350-364

  • [Journal Article] A Graphical Chain Modeling Approach for Analyzing Gene Expression Profiles2006

    • Author(s)
      Aburatani, S., Saito, S., Toh, H., Horimoto, K.
    • Journal Title

      Statist. Method. Vol.3

      Pages: 17-28

    • Peer Reviewed
  • [Journal Article] Serial Network Inference in Cell Cycle regulation on Yeast2006

    • Author(s)
      Aburatani, S. and Horimoto, K.
    • Journal Title

      Proceedings of the 10th World Multiconference on Systemics, Cybernetics and Informatics Vol.4

      Pages: 1-6

    • Peer Reviewed
  • [Presentation] Inference of Complex Regulatory Network for the Cell Cycle System in Saccharomyces cerevisiae2007

    • Author(s)
      Aburatani, S.
    • Organizer
      Algebraic Biology 2007
    • Place of Presentation
      RISC (Austria)
    • Year and Date
      20070700
  • [Presentation] ASIAN ; A Network Inference Web Server for Biologists2007

    • Author(s)
      Aburatani, S.
    • Organizer
      WMSCI2007
    • Place of Presentation
      Orland (USA)
    • Year and Date
      20070700
  • [Presentation] Serial Network Inference in Cell Cycle Regulation on Yeast2006

    • Author(s)
      Aburatani, S.
    • Organizer
      Horimoto, K., WMSCI2006
    • Place of Presentation
      Orland (USA)
    • Year and Date
      20060700
  • [Presentation] Inference of Cell Cycle Regulatory Network from Expression Profiles by Graphical Chain Modeling2006

    • Author(s)
      Aburatani, S., Saito, S., Horimoto, K.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto (Japan)
    • Year and Date
      20060600
  • [Book] Bioinformatics for Systems Biology : Chapter 29 : ASIAN : Network Inference Web Server (Stephen Krawetz 編集, 2009.2)2009

    • Author(s)
      Aburatani, S., Saito, S., Horimoto, K.
    • Total Pages
      740
    • Publisher
      Humana Press
  • [Book] マイクロアレイデータ統計解析プロトコール : 偏相関係数によるネットワーク推定グラフィカル・ガウシアン・モデル法", (藤渕航・堀本勝久 / 編, pp.224-233, 2008.4)2008

    • Author(s)
      油谷幸代
    • Total Pages
      255
    • Publisher
      羊土社
  • [Book] はじめてのバイオインフォマティクス : トランスクリプトームとプロテオーム (籐博幸 編集, pp97-123, 2006.12)2006

    • Author(s)
      油谷幸代
    • Total Pages
      166
    • Publisher
      講談社サイエンティフィック
  • [Remarks] ASIAN : 階層クラスタリングとグラフィカル・ガウシアン・モデリング(GGM)の組み合わせによるネットワーク推定ツール

    • URL

      http://eureka.cbrc.jp/asian/

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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