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2008 Fiscal Year Final Research Report

Site-specific mesenchymal-epithelial interactions elucidate pathogenesis of skindiseases and contribute to perfect tissue regeneration.

Research Project

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Project/Area Number 18689028
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionNagoya City University (2007-2008)
Osaka University (2006)

Principal Investigator

YAMAGUCHI Yuji  Nagoya City University, 大学院・医学研究科, 准教授 (00335340)

Project Period (FY) 2006 – 2008
Keywords皮膚腫瘍学 / 創傷治癒学 / 再生医学 / 色素細胞学 / 皮膚発生学
Research Abstract

「ヒト成人においても、上皮間葉系相互作用(真皮線維芽細胞がその上にある上皮系細胞に与える作用)により部位特異性(皮膚のさまざまな部位で性質が異なること)を決定付けていること」を実証してきた。手のひら・足のうらの皮膚は、分厚い皮膚で外からの刺激に強い・毛が無い・色素が薄いという3つの特徴がある。手のひら・足のうらの真皮線維芽細胞で発現が高いDKK1が、メラノサイトの機能を抑えるだけでなく、表皮細胞のメラニン取り込み能を抑制すると同時に、重層化を促進している結果を得ることが出来た。

  • Research Products

    (37 results)

All 2009 2008 2007 2006

All Journal Article (28 results) (of which Peer Reviewed: 28 results) Presentation (8 results) Book (1 results)

  • [Journal Article] Regulation of skin pigmentation and thickness by DKK12009

    • Author(s)
      Yamaguchi Y(4名・筆頭・責任著者) Morita A, et al.
    • Journal Title

      J Investig DermatolSymp Proc (in press)

    • Peer Reviewed
  • [Journal Article] Intractable wounds caused by pyoderma gangrenosum in a patient with critical limb ischemia treated with cyclosporine and adjuvant sympathectomy.2009

    • Author(s)
      Takahashi Y, Yamaguchi Y(6名・共筆頭・責任著者), et al.
    • Journal Title

      Dermatol Surg (Epub)

    • Peer Reviewed
  • [Journal Article] Short- and long-term effects of UV radiation on the skin.2009

    • Author(s)
      Coelho SG, 中略, Yamaguchi Y(15名・5番目), et al.
    • Journal Title

      J Investig Dermatol Symp Proc (in press)

    • Peer Reviewed
  • [Journal Article] Molecular basis of premature skin aging induced by tobacco smoking.2009

    • Author(s)
      Morita A, 中略, Yamaguchi Y(4名・最終著者)
    • Journal Title

      J Investig Dermatol Symp Proc (in press)

    • Peer Reviewed
  • [Journal Article] Stage III melanoma treated with chemotherapy after surgery during the second trimester of pregnancy.2009

    • Author(s)
      Ishida I, Yamaguchi Y(7名・共筆頭・責任著者), T et al.
    • Journal Title

      ArchDermatol 145(3)

      Pages: 346-8

    • Peer Reviewed
  • [Journal Article] The development of a filter to enhance the efficacy and safety of excimer light (308 nm) therapy.2009

    • Author(s)
      Kobayashi K, 中略, Yamaguchi Y(11名・10番目), et al.
    • Journal Title

      Photodermatol Photoimmunol Photomed 25(1)

      Pages: 30-6

    • Peer Reviewed
  • [Journal Article] Feasibility and a ccuracy of anewly developed hand-held device with a flat-type fluorescent lamp for measuring the minimal erythema dose for narrow-band UVB.2009

    • Author(s)
      Morita A, 中略, Yamaguchi Y(8名・7番目), et al.
    • Journal Title

      Photodermatol Photoimmunol Photomed 25(1)

      Pages: 41-4

    • Peer Reviewed
  • [Journal Article] Embryonic hair follicle fate change by augmented beta-catenin signaling through Shh and Bmp signaling.2009

    • Author(s)
      Suzuki K, Yamaguchi Y(13名・2番目), et al.
    • Journal Title

      Development 136(3)

      Pages: 367-72

    • Peer Reviewed
  • [Journal Article] Establishment of suction blister roof grafting by injection of local anesthesia beneath the epidermis : less painful and more rapid formation of blisters.2008

    • Author(s)
      Hanafusa T, Yamaguchi Y(14名・共筆頭・責任著者), et al.
    • Journal Title

      J Dermatol Sci 50(3)

      Pages: 243-7

    • Peer Reviewed
  • [Journal Article] BeerJZ, Hearing VJ. Melanin mediated apoptosis of epidermal cells damaged by ultraviolet radiation: factors influencing the incidence of skin cancer.2008

    • Author(s)
      Yamaguchi Y(3名・筆頭・責任著者)
    • Journal Title

      Arch DermatolRes (300 Suppl 1)

      Pages: S43-50

    • Peer Reviewed
  • [Journal Article] DKK1 regulates skin pigmentation and thickness by affecting Wnt/・-catenin signaling in keratinocytes.2008

    • Author(s)
      Yamaguchi Y(11名・筆頭・責任著者),Passeron T, et al.
    • Journal Title

      FASEB J 22(4)

      Pages: 1009-20

    • Peer Reviewed
  • [Journal Article] Involvement of dynein and spectrin with early melanosome transport and melanosomal protein trafficking.2008

    • Author(s)
      Watabe H, 中略, Yamaguchi Y(10名・4番目), et al.
    • Journal Title

      J Invest Dermatol 128(1)

      Pages: 162-74

    • Peer Reviewed
  • [Journal Article] Dynamics of pigmentation induction by repeated UV exposures: dose, dose interval and UV spectrum dependence.2008

    • Author(s)
      Miller SA, 中略, Yamaguchi Y(7名・5番目), et al.
    • Journal Title

      Br J Dermatol 159

      Pages: 921-30

    • Peer Reviewed
  • [Journal Article] Congenital peristernal dermal sinuses: a new entity?2008

    • Author(s)
      Kubo T, 中略, Yamaguchi Y(5名・3番目),et al.
    • Journal Title

      Br J Dermatol 159

      Pages: 763-5

    • Peer Reviewed
  • [Journal Article] Cyclobutane pyrimidine dimer formation and p53 production in human skin.2008

    • Author(s)
      Yamaguchi Y(7名・筆頭著者), Coelho SG, et al.
    • Journal Title

      Exp Dermatol 17(11)

      Pages: 916-24

    • Peer Reviewed
  • [Journal Article] Apocrine adenocarcinoma originating from the Moll's gland of the eyelid: report of a case.2008

    • Author(s)
      Kanazawa S, 中略, Yamaguchi Y(7名・4番目), et al.
    • Journal Title

      Eur J Plast Surg 31

      Pages: 333-6

    • Peer Reviewed
  • [Journal Article] Katayama I. Intractable wounds caused by arteriosclerosis obliterans with end-stage renal disease treated by aggressive debridement and epidermal grafting.2007

    • Author(s)
      Hanafusa T, Yamaguchi Y(3名・責任著者),
    • Journal Title

      J Am Acad Dermatol 57(2)

      Pages: 322-6

    • Peer Reviewed
  • [Journal Article] Intractable wounds caused by calcific uremic arteriolopathy treated with bisphosphonates.2007

    • Author(s)
      Hanafusa T, Yamaguchi Y(6名・責任著者),et al.
    • Journal Title

      J Am Acad Dermatol 57(6)

      Pages: 1021-5

    • Peer Reviewed
  • [Journal Article] IRegulation of human skin pigmentation and responses to UV radiation.2007

    • Author(s)
      Miyamura Y, 中略, Yamaguchi Y(14名・12番目), et al.
    • Journal Title

      Pigment Cell Res 20(1)

      Pages: 2-13

    • Peer Reviewed
  • [Journal Article] The effects of dickkopf 1 on gene expression and Wnt signaling by melanocytes: mechanisms underlying its suppression of melanocyte function and proliferation.2007

    • Author(s)
      Yamaguchi Y(7名・筆頭・責任著者),Passeron T, et al.
    • Journal Title

      J Invest Dermatol 127(5)

      Pages: 1217-25

    • Peer Reviewed
  • [Journal Article] Intractable wounds from a herpe ssimplex infection in an immunosuppressed patient with rheumatoid arthritis.2007

    • Author(s)
      Hanafusa T, Yamaguchi Y(4名・責任著者), et al.
    • Journal Title

      Arch Dermatol 143(10)

      Pages: 1340-2

    • Peer Reviewed
  • [Journal Article] Brenner M, Hearing VJ. The regulation of skin pigmentation.2007

    • Author(s)
      Yamaguchi Y(3名・筆頭著者),
    • Journal Title

      J Biol Chem 282(38)

      Pages: 27557-61

    • Peer Reviewed
  • [Journal Article] Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils.2007

    • Author(s)
      Valencia JC, Yamaguchi Y(14名・6番目), et al.
    • Journal Title

      J Biol Chem 282(15)

      Pages: 11266-80

    • Peer Reviewed
  • [Journal Article] UV increases the nuclear localization of APE/Ref-1 in human skin.2006

    • Author(s)
      Takahashi K, 中略, Yamaguchi Y(7名・3番目), et al.
    • Journal Title

      J Invest Dermatol 126(12)

      Pages: 2723-6

    • Peer Reviewed
  • [Journal Article] Human skin responses to UV radiation: pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis.2006

    • Author(s)
      Yamaguchi Y(9名・筆頭著者), TakahashiK, et al.
    • Journal Title

      FASEB J 20(9)

      Pages: 1486-8

    • Peer Reviewed
  • [Journal Article] Sorting of Pmel17 to melanosomes through the plasma membrane by AP1 and AP2 : evidence for the polarized nature of melanocytes.2006

    • Author(s)
      Valencia JC, 中略, Yamaguchi Y(14名・8番目), et al.
    • Journal Title

      J Cell Sci 119(Pt 6)

      Pages: 1080-91

    • Peer Reviewed
  • [Journal Article] Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG.2006

    • Author(s)
      Watari A, 中略, Yamaguchi Y(14名・8番目), et al.
    • Journal Title

      Oncogene 25(56)

      Pages: 7373-80

    • Peer Reviewed
  • [Journal Article] Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1 receptor isoforms.2006

    • Author(s)
      Rouzaud F, 中略, Yamaguchi Y(10名・3番目), et al.
    • Journal Title

      FASEB J 20(11)

      Pages: 1927-9

    • Peer Reviewed
  • [Presentation] Adult dermal fibroblasts determine the fate of the overlying epidermis.2009

    • Author(s)
      Yamaguchi Y.
    • Organizer
      The Global COE Liaison Laboratory regular seminar
    • Place of Presentation
      [Invited lecturer] Kumamoto, Japan.
    • Year and Date
      2009-05-04
  • [Presentation] The effect of UV on human skin pigmentation.2009

    • Author(s)
      Yamaguchi Y.
    • Organizer
      The 3rd Annual Symposium in Institute of Dermatological Science
    • Place of Presentation
      [Invited lecturer] Seoul, Korea.
    • Year and Date
      2009-02-06
  • [Presentation] Melanocyte Biology2009

    • Author(s)
      Yamaguchi Y .
    • Organizer
      Pre-seminar for the 3rd Annual Symposium in Institute of Dermatological Science
    • Place of Presentation
      [Invited lecturer] Seoul, Korea.
    • Year and Date
      2009-02-05
  • [Presentation] Workshop : CS-14 Molecular and surgical pathology.2008

    • Author(s)
      Yamaguchi Y.
    • Organizer
      The 20th International Pigment Cell Conference and 5th International Melanoma Research Conference.
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      20080507-12
  • [Presentation] Regulation of skin pigmentation and thickness by dickkopf 1(DKK1).2008

    • Author(s)
      Yamaguchi Y.
    • Organizer
      IID 2008 Satellite Symposium Photoaging Research Symposium
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2008-05-13
  • [Presentation] Epidermal sheet grafting for chronic wound.Workshop : Modern wound management.2007

    • Author(s)
      Yamaguchi Y.
    • Organizer
      The 21st World Congress of Dermatology.
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      20070930-1005
  • [Presentation] The effects of dickkopf 1 on gene expression and Wnt signaling by keratinocytes: mechanisms regulating skin pigmentation and thickness.2007

    • Author(s)
      Yamaguchi Y, Passeron T, Katayama I, Hearing VJ.
    • Organizer
      The 68th Annual Meeting of the Society for Investigative Dermatology.
    • Place of Presentation
      LosAngeles, CA, USA
    • Year and Date
      20070509-12
  • [Presentation] Regulation of skin pigmentation.2007

    • Author(s)
      Yamaguchi Y .
    • Organizer
      Avon Lecture Series for Pigment Cell Research.
    • Place of Presentation
      New York, NY, USA
    • Year and Date
      2007-05-15
  • [Book] Melanocyte distribution and function in human skin2006

    • Author(s)
      Yamaguchi Y(2名・筆頭著者)
    • Total Pages
      101-115
    • Publisher
      Humana Press

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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