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2008 Fiscal Year Final Research Report

Investigation of pathophysiology of schizophrenia by dysbindin gene

Research Project

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Project/Area Number 18689030
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionOsaka University

Principal Investigator

HASHIMOTO Ryota  Osaka University, 医学系研究科, 特任准教授 (10370983)

Project Period (FY) 2006 – 2008
Keywords統合失調症 / ディスバインジン / 遺伝子解析 / 認知機能 / 記憶
Research Abstract

統合失調症の脆弱性遺伝子は、統合失調症という疾患そのものの原因ではなく、記憶機能などの中間表現型と強く関連し、その結果として統合失調症と関連すると考えられている。統合失調症に対して保護的なディスバインジン遺伝子のハプロタイプを持たない健常者は、保護的なハプロタイプを持つ健常者と比較して、WMS-R記憶検査にて測定した言語性記憶、視覚性記憶、そして遅延再生のスコアが有意に低く、同じような傾向が、統計学的には有意ではないものの統合失調症患者においても認められた。これらの結果は、統合失調症のリスクとなるディスバインジン遺伝子の中間表現型は記憶機能であり、統合失調症の記憶障害に関与する遺伝子であることを示唆した。

  • Research Products

    (62 results)

All 2009 2008 2007 2006 Other

All Journal Article (28 results) (of which Peer Reviewed: 28 results) Presentation (28 results) Remarks (6 results)

  • [Journal Article] Impaired regional hemodynamic response in schizophrenia during multiple prefrontal activation tasks : a two-channel near-infrared spectroscopy study2009

    • Author(s)
      Ikezawa, K, Iwase, M, Ishii R, Azechi M, Canuet L, Ohi K, Yuka Yasuda, Iike N, Kurimoto R, Takahashi H, Nakahachi T, Sekiyama R, Yoshida T, Kazui H, Hashimoto R, Takeda M.
    • Journal Title

      Schizophr Res 108(1-3)

      Pages: 93-103

    • Peer Reviewed
  • [Journal Article] Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia.2008

    • Author(s)
      Takao K, Toyama K, Nakanishi K, Hattori S, Takamura H, Takeda M , Miyakawa T, Hashimoto R.
    • Journal Title

      Mol Brain 1(1)

      Pages: 11

    • Peer Reviewed
  • [Journal Article] Impaired prepulse inhibition and habituation of acoustic startle response in Asian patients with schizophrenia.2008

    • Author(s)
      Takahashi H, Iwase M, Ishii R, Ohi K, Fukumoto M, Azechi M, Ikezawa K, Kurimoto R, Canuet L, Nakahachi T, Iike N, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Yoshida T, Yasuda Y, Hashimoto R, Takeda M.
    • Journal Title

      Neuroscience Res 62(3)

      Pages: 187-197

    • Peer Reviewed
  • [Journal Article] Difficulty identifying spinocerebellar ataxia 17 from preceding psychiatric symptoms.2008

    • Author(s)
      Ohi K, Hashimoto R, Sugai F, Yasuda Y, Tagami S, Takamura H, Morihara T, Okochi M, Tanaka T, Kudo T, Sakoda S, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci 62(5)

      Pages: 625

    • Peer Reviewed
  • [Journal Article] Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia.2008

    • Author(s)
      Hattori S, Murotani T, Matsuzaki S, Ishizuka T, Kumamoto N, Takeda M, Tohyama M, Yamatodani A, Kunugi H, Hashimoto R.
    • Journal Title

      Biochem Biophys Res Commun 373(2)

      Pages: 298-302

    • Peer Reviewed
  • [Journal Article] Dose Dependent Effect of the Val66Met Polymorphism of the Brain-Derived Neurotrophic Factor Gene on Memory-Related Hippocampal Activity.2008

    • Author(s)
      Hashimoto R, Moriguchi Y, Yamashita F, Mori T, Nemoto K, Okada T, Hori H, Noguchi H, Kunugi H, Ohnishi T.
    • Journal Title

      Neuroscience Res 61(4)

      Pages: 360-367

    • Peer Reviewed
  • [Journal Article] Microarray comparative genomic hybridization analysis of 59 patients with schizophrenia.2008

    • Author(s)
      Mizuguchi T, Hashimoto R, Itokawa M, Sano A, Shimokawa O, Yoshimura Y, Harada N, Miyake N, Nishimura A, Saitsuh H, Sosonkina N, Niikawa N, Kunugi H, Matsumoto N.
    • Journal Title

      J Hum Genet 53(10)

      Pages: 914-919

    • Peer Reviewed
  • [Journal Article] Impairment of motor dexterity in schizophrenia assessed by a novel finger-movement test2008

    • Author(s)
      Midorikawa A, Hashimoto R, Noguchi H, Saitoh O, Kunugi H, Nakamura K.
    • Journal Title

      Psychiatry Res 159

      Pages: 281-289

    • Peer Reviewed
  • [Journal Article] Personality in schizophrenia assessed with the Temperament and Character Inventory (TCI)2008

    • Author(s)
      Hori H, Noguchi H, Hashimoto R, Nakabayashi T, Saitoh O, Murray RM, Okabe S, Kunugi H.
    • Journal Title

      Psychiatry Res 160(2)

      Pages: 175-183

    • Peer Reviewed
  • [Journal Article] IQ decline and memory impairment in Japanese patients with chronic schizophrenia2008

    • Author(s)
      Hori H, Noguchi H, Hashimoto R, Saitoh O, Okabe S, Kunugi H.
    • Journal Title

      Psychiatry Res 158

      Pages: 251-255

    • Peer Reviewed
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia2007

    • Author(s)
      Hashimoto R, Hashimoto H, Shintani N, Chiba S, Hattori S, Okada T, Nakajima M, Tanaka K, Kawagishi N, Nemoto K, Mori T, Ohnishi T, Noguchi H, Hori H, Suzuki T, Iwata N, Ozaki N, Nakabayashi T, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Kunugi H, Baba A
    • Journal Title

      Mol Psychiatry 12

      Pages: 1026-1032

    • Peer Reviewed
  • [Journal Article] A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects2007

    • Author(s)
      Hashimoto R, Noguchi H, Hori H, Ohi K, Yasuda Y, Takeda M, Kunugi H.
    • Journal Title

      Neurosci lett 428(1)

      Pages: 17-20

    • Peer Reviewed
  • [Journal Article] High dopamine turnover in the brains of Sandy mice.2007

    • Author(s)
      Murotani T, Ishizuka T, Hattori S, Hashimoto R, Matsuzaki S, Yamatodani A.
    • Journal Title

      Neurosci Lett. 421(1)

      Pages: 47-51

    • Peer Reviewed
  • [Journal Article] Postsynaptic density: A key convergent site for schizophrenia susceptibility factors and possible target for drug development2007

    • Author(s)
      Hashimoto R, Tankou S, Takeda M, Sawa A.
    • Journal Title

      Drugs Today (Barc) 43(9)

      Pages: 645-654

    • Peer Reviewed
  • [Journal Article] Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology, and ERK signaling.2006

    • Author(s)
      Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, Mori T, Nemoto K, Adachi N, Izumi A, Chiba S, Noguchi H, Suzuki T, Iwata N, Ozaki N, Taguchi T, Kamiya A, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Sawa A, Kunugi H.
    • Journal Title

      Hum Mol Genet 15

      Pages: 3024-3033

    • Peer Reviewed
  • [Journal Article] The association between the Val158Met polymorphism of the Catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia.2006

    • Author(s)
      Ohnishi T, Hashimoto R, Mori T, Nemoto K, Moriguchi Y, Iida H, Yamada M, Noguchi H, Nakabayashi T, Hori H, Ohmori M, Tsukue R, Anami K, Hirabayashi N, Harada S, Arima K, Saitoh O, Kunugi H.
    • Journal Title

      Brain 129

      Pages: 399-410

    • Peer Reviewed
  • [Journal Article] A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity.2006

    • Author(s)
      Okada T, Hashimoto R, Numakawa T, Iijima Y, Kosuga A, Tatsumi M, Kamijima K, Kato T, Kunugi H.
    • Journal Title

      Mol Psychiatry 11

      Pages: 695-703

    • Peer Reviewed
  • [Journal Article] Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus.2006

    • Author(s)
      Chiba S, Hashimoto R, Hattori S, Yohda M, Lipska B, Weinberger DR, Kunugi H.
    • Journal Title

      J Neural Transm 113

      Pages: 1337-1346

    • Peer Reviewed
  • [Journal Article] Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population.2006

    • Author(s)
      Kunugi H, Hashimoto R, Okada T, Hori H, Nakabayashi T, Baba A, Kudo K, Ohmori M, Takahashi S, Tsukue R, Anami K, Hirabayashi N, Kosuga A, Tatsumi M, Kamijima K, Asada T, Harada S, Arima K, Saitoh O.
    • Journal Title

      J Neural Transm 113

      Pages: 1569-1573

    • Peer Reviewed
  • [Journal Article] Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease.2006

    • Author(s)
      Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R, Harrison PJ, Kleinman JE, Weinberger DR.
    • Journal Title

      Proc Natl Acad Sci U S A 103(17)

      Pages: 6747-6752

    • Peer Reviewed
  • [Journal Article] Hyperactivation of Midbrain Dopaminergic System in Schizophrenia could be attributed to the Down-regulation of Dysbindin.2006

    • Author(s)
      Kumamoto N, Matsuzaki S, Inoue K, Hattori T, Shimizu S, Hashimoto R, Yamatodani A, Katayama T, Tohyama M.
    • Journal Title

      Biochem Biophys Res Commun 345

      Pages: 904-909

    • Peer Reviewed
  • [Journal Article] The association analysis between the dysbindin gene (DTNBP1) and cognitive functions in Japanese subjects.

    • Author(s)
      Hashimoto R, Noguchi H, Hori H, Ohi K, Yasuda Y, Takeda M, Kunugi H.
    • Journal Title

      Psychiatry Clin Neurosci in press

    • Peer Reviewed
  • [Journal Article] A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls.

    • Author(s)
      Hashimoto R, Noguchi H, Hori H, Nakabayashi T, Suzuki T, Iwata N, Ozaki N, Kosuga A, Tatsumi M, Kamijima K, Harada S, Saitoh O, Takeda M, Kunugi H.
    • Journal Title

      The World Journal of Biological Psychiatry in press

    • Peer Reviewed
  • [Journal Article] Association study of the G72 gene with schizophrenia in a Japanese population : a multicenter study.

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Fukumoto M, Takamura H, Iwase M, Kamino K, Ishii R, Kazui H, Sekiyama R, Kitamura Y, Azechi M, Ikezawa K, Kurimoto R, Kamagata E, Tanimukai H, Tagami S, Morihara T, Ogasawara M, Okochi M, Tokunaga H, Numata S, Ikeda M, Ohnuma T, Ueno S, Fukunaga T, Tanaka T, Kudo T, Arai H, Ohmori T, Iwata N, Ozaki N, Takeda M.
    • Journal Title

      Schizophr Res in press

    • Peer Reviewed
  • [Journal Article] TATA Box-Binding Protein gene is associated with risk for schizophrenia, age at onset and prefrontal function.

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Kiribayashi M, Iike N, Yoshida T, Azechi M, Ikezawa K, Takahashi H, Morihara T, Ishi R, Tagami S, Iwase M, Okochi M, Kamino K, Kazui H, Tanaka T, Kudo T, Takeda M.
    • Journal Title

      Genes, Brain and Behavior in press

    • Peer Reviewed
  • [Journal Article] Dysbindin engages in c-Jun N-terminal kinase activity and cytoskeletal organization

    • Author(s)
      Kubota K, Kumamoto N, Matsuzaki S, Hashimoto R, Hattori T, Okuda H, Takamura H, Takeda M, Katayama T, Tohyama M.
    • Journal Title

      Biochem Biophys Res Commun in press

    • Peer Reviewed
  • [Journal Article] Effect of the BDNF and the ApoE polymorphisms on disease progression in preclinical Alzheimer's disease, Genes,

    • Author(s)
      Hashimoto R, Hirata Y, Asada T, Yamashita F, Nemoto K, Mori T, Moriguchi Y, Kunugi H, Arima K, Ohnishi T.
    • Journal Title

      Brain and Behavior in press

    • Peer Reviewed
  • [Journal Article] Abnormal microstructures of the basal ganglia in schizophrenia revealed by diffusion tensor imaging.

    • Author(s)
      Hashimoto R, Mori T, Nemoto K, Moriguchi Y, Noguchi H, Nakabayashi T, Hori H, Harada S, Kunugi H, Saitoh O, Ohnishi T.
    • Journal Title

      The World Journal of Biological Psychiatry in press

    • Peer Reviewed
  • [Presentation] シンポジウム : 統合失調症の未病と予防「統合失調症未病と広汎性発達障害との類似点と相違点」2009

    • Author(s)
      橋本亮太、 安田由華、大井一高、吉田哲彦、福本素由己、高村明孝、高橋秀俊、井池直美、工藤喬、石井良平、岩瀬真生、数井裕光、武田雅俊
    • Organizer
      日本統合失調症学会第4回大会
    • Place of Presentation
      大阪
    • Year and Date
      20090130-31
  • [Presentation] Symposium. Dysbindin : pathological clue for developing schizophrenia.2008

    • Author(s)
      Hashimoto R.
    • Organizer
      XIV World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      20081011-15
  • [Presentation] Symposium. Studying candidate genes of lithium response in the Japanese population.2008

    • Author(s)
      Hashimoto R, Masui T, Koyama T, Takeda M.
    • Organizer
      XIV World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      20081011-15
  • [Presentation] Imaging genetics: combination of genetic factors for schizophrenia and brain MRI findings2008

    • Author(s)
      Hashimoto R, Ohnishi T
    • Organizer
      2^<nd> WFSBP Asia-Pacific Congress and 30^<th> Annual Meeting of JSBP
    • Place of Presentation
      Toyama, Japan
    • Year and Date
      20080911-13
  • [Presentation] Translational research in mental disorder.2008

    • Author(s)
      Hashimoto R
    • Organizer
      The 51st Annual Meeting of the Japanese Society for Neurochemistry
    • Place of Presentation
      Toyama, Japan
    • Year and Date
      20080911-13
  • [Presentation] Identification of susceptibility genes for schizophrenia using intermediate phenotype2008

    • Author(s)
      Hashimoto R, Takeda M
    • Organizer
      The 51st Annual Meeting of the Japanese Society for Neurochemistry
    • Place of Presentation
      Toyama, Japan
    • Year and Date
      20080911-13
  • [Presentation] 、統合失調症脆弱性遺伝子ディスバインジンによる統合失調症の病態研究2008

    • Author(s)
      橋本亮太、服部聡子、室谷知孝、松崎伸介、河本恵介、山田浩平、桑原隆亮、石塚智子、熊本奈都子、武田雅俊、遠山正彌、大和谷厚、功刀浩
    • Organizer
      第31回日本神経科学学会
    • Place of Presentation
      東京
    • Year and Date
      20080709-11
  • [Presentation] 統合失調症脆弱性遺伝子ディスバインジンによる統合失調症の病態解明研究2008

    • Author(s)
      橋本亮太、安田由華、大井一高、福本素由己、功刀浩、武田雅俊
    • Organizer
      第104回日本精神神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      20080529-31
  • [Presentation] Symposium : New researches of neuropsychopharmacology in Asian Countries, Translational research for schizophrenia : genes, intermediate phenotypes, and function2008

    • Author(s)
      Hashimoto R
    • Organizer
      2008 Meeting of Korean College of Neuropsychopharmacology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      20080327-28
  • [Presentation] 統合失調症脆弱性遺伝子ディスバインジンによる統合失調症の病態解明研究2008

    • Author(s)
      橋本亮太、服部聡子、室谷知孝、松崎伸介、石塚智子、熊本奈都子、遠山正彌、大和谷厚、功刀浩、武田雅俊
    • Organizer
      第三回統合失調症学会
    • Place of Presentation
      東京
    • Year and Date
      20080314-15
  • [Presentation] Dysbindin and drug development for schizophrenia2008

    • Author(s)
      Hashimoto R, Takamura H, Ohi K, Fukumoto M, Yamamori H, Yasuda Y, Takeda M
    • Organizer
      The 1^<st> Asian Workshop on Schizophrenia Research
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      20080131-0201
  • [Presentation] 統合失調症の病態と前頭葉機能2008

    • Author(s)
      橋本亮太
    • Organizer
      第18回神経科学の基礎と臨床
    • Place of Presentation
      大阪
    • Year and Date
      2008-12-13
  • [Presentation] Translational Research for Schizophrenia2007

    • Author(s)
      Hashimoto R
    • Organizer
      4^<th> Japanese-German Frontiers of Science Symposium
    • Place of Presentation
      Shonan, Japan
    • Year and Date
      20071101-04
  • [Presentation] Genetic variations in the dysbindin gene are associated with human memory performance2007

    • Author(s)
      Hashimoto R, Noguchi H, Hori H, Nakabayashi T, Hattori S, Chiba S, Harada S, Takeda M, Saitoh O, Kunugi H.
    • Organizer
      IPA 2007 Osaka Silver Congress
    • Place of Presentation
      Osaka
    • Year and Date
      20071014-18
  • [Presentation] 、PACAP遺伝子は統合失調症と関連する2007

    • Author(s)
      橋本亮太、功刀浩、馬場明道
    • Organizer
      第50回日本神経化学会・第30回日本神経科学学会・第17回日本神経回路学会合同年会
    • Place of Presentation
      横浜
    • Year and Date
      20070910-12
  • [Presentation] 統合失調症脆弱性遺伝子であるディスバインジン欠損マウスにおける異常行動2007

    • Author(s)
      橋本亮太、服部聡子、室谷知孝、松崎伸介、石塚智子、熊本奈都子、武田雅俊、遠山正彌、大和谷厚、功刀浩
    • Organizer
      第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
    • Place of Presentation
      札幌
    • Year and Date
      20070711-13
  • [Presentation] 統合失調症脆弱性遺伝子ディスバインジンによる統合失調症の病態解明研究2007

    • Author(s)
      橋本亮太、安田由華、大井一高、井池直美、功刀浩、武田雅俊
    • Organizer
      第103回日本精神神経学会総会
    • Place of Presentation
      高知
    • Year and Date
      20070517-19
  • [Presentation] Symposium: Pathogenesis of schizophrenia, dysbindin and pathogenesis of schizophrenia2007

    • Author(s)
      Hashimoto R
    • Organizer
      2^<nd> International Congress of Biological Psychiatry
    • Place of Presentation
      Santiago, Chili
    • Year and Date
      20070417-21
  • [Presentation] 統合失調症脆弱性遺伝子ディスバインジンによる統合失調症の病態解明研究2007

    • Author(s)
      橋本亮太、服部聡子、安田由華、大井一高、井池直美、松崎伸介、熊本奈都子、遠山正彌、功刀浩、武田雅俊
    • Organizer
      第二回統合失調症学会
    • Place of Presentation
      富山
    • Year and Date
      20070324-25
  • [Presentation] 統合失調症と気分障害の病態生理研究の動向、統合失調症のトランスレーショナルリサーチ2006

    • Author(s)
      橋本亮太、武田雅俊
    • Organizer
      分子生物学会2006フォーラム
    • Place of Presentation
      名古屋
    • Year and Date
      20061206-08
  • [Presentation] Translational Research for Schizophrenia2006

    • Author(s)
      Hashimoto R
    • Organizer
      3rdJapanese-German Frontiers of Science Symposium
    • Place of Presentation
      Heidelberg, Germany
    • Year and Date
      20061102-05
  • [Presentation] Genetic variation in dysbindin influences memory and general cognitive ability2006

    • Author(s)
      Hashimoto R, Noguchi H, Hori H, Nakabayashi T, Hattori S, Chiba S, Harada S, Saitoh O, Takeda M, Kunugi H.
    • Organizer
      The 36th annual meeting of Society for Neuroscience
    • Place of Presentation
      Georgia, USA
    • Year and Date
      20061014-18
  • [Presentation] 合同シンポジウム「エンドフェノタイプを利用したゲノム研究」、PACAP遺伝子と統合失調症の関連2006

    • Author(s)
      橋本亮太、功刀浩、馬場明道
    • Organizer
      第28回日本生物学的精神医学会・第49回日本神経化学会・第36回日本神経精神薬理学会合同年会
    • Place of Presentation
      名古屋
    • Year and Date
      20060914-16
  • [Presentation] Genetic variants in dysbindin, a susceptibility gene for schizophrenia, influence cognitive function2006

    • Author(s)
      Hashimoto R, Noguchi, H, Hori H, Nakabayashi T, Hattori S, Chiba S, Harada S, Takeda M, Saitoh O, Kunugi H
    • Organizer
      第28回日本生物学的精神医学会・第49回日本神経化学会・第36回日本神経精神薬理学会合同年会
    • Place of Presentation
      名古屋
    • Year and Date
      20060914-16
  • [Presentation] 統合失調症脆弱性遺伝子であるディスバインジンの遺伝子多型は記憶やIQと関連する2006

    • Author(s)
      橋本亮太、野口広子、堀弘明、服部聡子、千葉幸恵、原田誠一、斉藤治、功刀浩
    • Organizer
      第29回日本神経科学学会年会
    • Place of Presentation
      京都
    • Year and Date
      20060719-21
  • [Presentation] Dysbindin and pathogenesis of schizophrenia2006

    • Author(s)
      Hashimoto R
    • Organizer
      The 7th Biennial Meeting of the Asian-Pacific Society for Neurochemistry (APSN)
    • Place of Presentation
      Singapore
    • Year and Date
      20060702-05
  • [Presentation] 統合失調症脆弱性遺伝子ディスバインジンによる統合失調症の分子病態研究2006

    • Author(s)
      橋本亮太、野口広子、堀弘明、功刀浩
    • Organizer
      第102回日本精神神経学会総会
    • Place of Presentation
      博多
    • Year and Date
      20060511-13
  • [Presentation] 精神疾患の包括的研究2006

    • Author(s)
      橋本亮太
    • Organizer
      浜松医大精神科セミナー
    • Place of Presentation
      浜松
    • Year and Date
      2006-06-12
  • [Remarks] 「統合失調症関与の遺伝子 大阪大教授ら発見」読売新聞、2007年3月27日

  • [Remarks] 「統合失調症の発症関与の遺伝子発見 大阪大 」毎日新聞 、2007年3月28日

  • [Remarks] 「統合失調症外来を開設 阪大グループ-治療法を研究」読売新聞、2007年6月4日

  • [Remarks] 「阪大に統合失調症外来 発症の仕組みも研究」朝日新聞、2007年6月17日

  • [Remarks] 「統合失調症短期で改善目指す 阪大大学院精神医学教室 新入院プログラム開始」毎日新聞、2009年2月3日

  • [Remarks] 研究のURL

    • URL

      http://www.med.osaka-u.ac.jp/pub/psy/www/jp/labo/sp/index.htm

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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