FULL-AUTOMATIC QUANTIFICATION OF KNEE OSTEOARTHRITIS SEVERITY ON STANDARD RADIOGRAPHS BY A NOVEL COMPUTER-ASSISTED SYSTEM

2008 Fiscal Year Final Research Report

• Project/Area Number: 18689031
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: The University of Tokyo
• Principal Investigator: OKA Hiroyuki The University of Tokyo, 医学部附属病院, 特任助教 (60401064)
• Project Period (FY): 2006 – 2008
• Keywords: 画像診断学(含放射線診断学、核医学)

Research Abstract

現在、変形性関節症(osteoarthritis:OA)のX線画像評価基準として、カテゴリカルな評価法であるKellgren-Lawrenceグレードが広く用いられているが、読影者の主観で評価が異なり、微細な変化を検出することができない。このため、X線画像を一定の基準で自動的に評価できるソフトウエアの開発を行った。本システムは、関節裂隙・骨棘などの6項目について計測し、OAの診断に際して客観的な数値を表すことができるため、評価基準の明確化に寄与するものと考えている。

Research Products

• [Journal Article] Sleep apnea in rheumatoid arthritis patients with occipitocervical lesions: the prevalence and associated radiographic features (2009)
  • Author(s): Shoda N, Seichi A, Takeshita K, Chikuda H, Ono T, Oka H, Kawaguchi H, Nakamura K
  • Journal Title: Eur Spine J (in press)
  • Peer Reviewed
• [Journal Article] Prevalence of radiographic lumbar spondylosis and its association with low back pain in the elderly of population-based cohorts: the ROAD study (2009)
  • Author(s): Muraki S, Oka H, Mabuchi A, Akune T, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Ann Rheum Dis (in press)
  • Peer Reviewed
• [Journal Article] Epidemiology of lumbar osteoporosis and osteoarthritis and their causal relationship-Is osteoarthritis a predictor for osteoporosis, or vice-versa?: The Miyama Study (2009)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kinoshita H, Yoshida M, Mabuchi A, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: Osteoporos Int (in press)
  • Peer Reviewed
• [Journal Article] Association of occupational activity with radiographic knee osteoarthritis and lumbar spondylosis in the elderly of population-based cohorts: the ROAD study (2009)
  • Author(s): Muraki S, Akune T, Oka H, Mabuchi A, Akune T, En-yo Y, Yoshida M, Saika A, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Arthritis Care & Research (in press)
  • Peer Reviewed
• [Journal Article] Prevalence of knee osteoarthritis, lumbar spondylosis and osteoporosis in Japanese men and women: The Research on Osteoarthritis/osteoporosis Against Disability (ROAD) (2009)
  • Author(s): Yoshimura N, Muraki S, Oka H, Mabuchi A, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: J Bone Miner Metab (in press)
  • Peer Reviewed
• [Journal Article] アジア諸国における脊椎椎体骨折有病率の比較:The Asian Vertebral Osteoporosis Study (AVOS) (2009)
  • Author(s): 吉村典子, 阿久根徹, 村木重之, 岡敬之, 川口浩, 中村耕三, Edith MC Lau, Anthony Kwok, Ping-chung Leung
  • Journal Title: Osteoporos Jpn 17 (in press)
  • Peer Reviewed
• [Journal Article] Association between height loss and bone loss, cumulative incidence of vertebral fractures and future QOL: The Miyama Study (2008)
  • Author(s): Yoshimura N, Kinoshita H, Oka H, Muraki S, Mabuchi A, Kawaguchi H, Nakamura K, Nakamura T
  • Journal Title: Osteoporos Int 19 Pages: 21-28
  • Peer Reviewed
• [Journal Article] Fully automatic quantification of knee osteoarthritis severity on standard radiographs (2008)
  • Author(s): Oka H, Muraki S, Akune T, Mabuchi A, Suzuki T, Yoshida H, Yamamoto S, Nakamura K, Yoshimura N, Kawaguchi H
  • Journal Title: Osteoarthritis and Cartilage 16 Pages: 1300-1306
  • Peer Reviewed
• [Journal Article] 骨粗鬆症の発生率と骨代謝マーカー、内因性ホルモンとの関連:漁村コホート10年間の追跡 (2008)
  • Author(s): 吉村典子, 岡敬之, 村木重之, 阿久根徹, 馬淵昭彦, 川口浩, 中村耕三
  • Journal Title: Osteoporos Jpn 16 Pages: 40-44
  • Peer Reviewed
• [Journal Article] コンピュータを用いた大腿骨頸部骨形態自動計測法の開発 (2008)
  • Author(s): 村木重之, 阿久根徹, 岡敬之, 吉村典子
  • Journal Title: Osteoporos Jpn 16 Pages: 644-647
  • Peer Reviewed
• [Journal Article] Diet and lifestyle associated with increased bone mineral density: cross-sectional study of Japanese elderly women at an osteoporosis outpatient clinic (2007)
  • Author(s): Muraki S, Yamamoto S, Ishibashi H, Oka H, Yoshimura N, Kawaguchi H, Nakamura K
  • Journal Title: J Orthop Sci 12 Pages: 317-320
  • Peer Reviewed
• [Journal Article] Risk factors for knee osteoarthritis in Japanese men: A case control study (2006)
  • Author(s): Yoshimura N, Kinoshita H, Hori N, Nishioka T, Ryujin M, Mantani Y, Miyake M, Takeshita T, Ichinose M, Yoshida M, Oka H, Kawaguchi H, Nakamura K, Cooper C
  • Journal Title: Modern Rheumatology 16 Pages: 24-29
  • Peer Reviewed
• [Journal Article] Decreased activities of daily living and associations with bone loss among aged residents in a rural Japanese community: The Miyama Study (2006)
  • Author(s): Oka H, Yoshimura N, Kinoshita H, Saika A, Kawaguchi H, Nakamura K
  • Journal Title: J Bone Miner Metab 24 Pages: 307-313
  • Peer Reviewed
• [Journal Article] Cumulative Incidence and Changes in Prevalence of Vertebral Fractures in a Rural Japanese Community: A 10-year Follow-up of the Miyama Cohort (2006)
  • Author(s): Yoshimura N, Kinoshita H, Oka H, Muraki S, Mabuchi A, Kawaguchi H, Nakamura K
  • Journal Title: Archives Osteoporos, DOI 10 Pages: 1007/s11657-006-0007-0
  • Peer Reviewed
• [Journal Article] Prognostic factors for patients with spinal metastases from lung cancer (2006)
  • Author(s): Ogihara S, Seichi A, Hozumi T, Oka H, Ieki R, Namamura K, Kondoh T
  • Journal Title: Journal Article Spine 31(14) Pages: 1585-90
  • Peer Reviewed
• [Journal Article] Incidence and prognostic factors of Japanese breast cancer patients with bone metastasis (2006)
  • Author(s): Oka H, Kondoh T, Seichi A, Hozumi T, Nakamura K
  • Journal Title: J Orthop Sci. 11 Pages: 13-9
  • Peer Reviewed
• [Journal Article] 骨粗鬆症と変形性関節症の因果関係に関する研究(報告) (2006)
  • Author(s): 吉村典子, 雑賀明宏, 岡敬之
  • Journal Title: Osteoporos Jpn 14 Pages: 25-29
  • Peer Reviewed
• [Presentation] Association of Radiographic Severity of Knee Osteoarthritis with Symptomatic Parameters: The ROAD Study (2008)
  • Author(s): Akune T, Muraki S, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: APLAR 2008-The 13th International Congress of the Asia Pacific League of Associations for Rheumatism
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 20080923-27
• [Presentation] Association of Radiographic Severity of Knee Osteoarthritis with Symptomatic Parameters: The ROAD (Research on Osteoarthritis Against Disability) Study (2008)
  • Author(s): Akune T, Muraki S, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: OARSI 2008 World Congress on Osteoarthritis
  • Place of Presentation: Rome, Italy
  • Year and Date: 20080918-21
• [Presentation] Predictive Capacity of Biochemical Markers of Bone Turnover and Endogenous Hormones for Osteoporosis in Men: Ten-year Follow-up of a Japanese Cohort (2008)
  • Author(s): Yoshimura N, Oka H, Muraki T, Akune T, Kawaguchi H, Nakamura N
  • Organizer: 30th Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Canada, USA
  • Year and Date: 20080900
• [Presentation] Lateral joint srace narrowing on radiographs predicts pain progression in knee osteoarthritis patients: application of fully automatic KOACAD system to OAI public data (2008)
  • Author(s): Oka H, Akune T, Muraki S, Nakamura K, Yoshimura N, Kawaguchi H
  • Organizer: Osteoarthritis Research Society International
  • Place of Presentation: Roma, Italy
  • Year and Date: 20080900
• [Presentation] Fully automatic quantification of knee osteoarthritis severity on standard radiographs by a novel computer assisted system (2007)
  • Author(s): Oka H, Yoshimura N, Muraki S, Mabuchi A, Nakamura K, Kawaguchi H
  • Organizer: OARSI for the 2007 World Congress on Osteoarthritis
  • Place of Presentation: Ft. Lauderdale, Florida
  • Year and Date: 20071200
• [Presentation] Risk factors for radiographic knee osteoarthritis and lumbar spondylosis: the road study (2007)
  • Author(s): Muraki S, Oka H, Mabuchi A, En-yo Y, Suzuki M, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: OARSI for the 2007 World Congress on Osteoarthritis
  • Place of Presentation: Ft. Lauderdale, Florida
  • Year and Date: 20071200
• [Presentation] Is osteoporosis related to future incidence of osteoarthritis over 10 years, or vice-versa? (2007)
  • Author(s): Yoshimura N, Muraki S, Oka H, Mabuchi A, En-yo Y, Kawaguchi H, Nakamura K
  • Organizer: nnual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Honolulu, USA
  • Year and Date: 20070900
• [Presentation] Prevalence of radiographic osteoarthritis of knee and lumbar spine and its association with pain: the research on osteoarthritis against disability (ROAD) study (2007)
  • Author(s): Muraki S, Oka H, Mabuchi A, En-yo Y, Yoshida M, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Honolulu, USA
  • Year and Date: 20070900
• [Presentation] Fullautomatic measurement of knee osteoarthritis parameters by a novel computer assisted system on standard radiograph (2007)
  • Author(s): Oka H, Yoshimura N, Muraki S, Mabuchi A, Nakamura K, Kawaguchi H
  • Organizer: Osteoarthritis Reseach Society International
  • Place of Presentation: Salzburg, Austria
  • Year and Date: 20070700
• [Presentation] Osteoporosis and osteoarthritis. Is osteoporosis a predictor of the incidence of osteoarthritis, or vice-versa? (2007)
  • Author(s): Yoshimura N, Muraki S, Oka H, Mabuchi A, Kawaguchi H, Nakamura K
  • Organizer: Annual meeting of the Europena Calcified Tissue Society
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 20070500
• [Presentation] Association of radiographic osteoarthritis of knee and lmbar spine with pain (2007)
  • Author(s): Muraki S, Yoshimura N, Oka H, Mabuchi A, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Kawaguchi H, Nakamura K
  • Organizer: Annual meeting of the Europena Calcified Tissue Society
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 20070500
• [Presentation] Prevalence of radiographic osteoarthritis of knee and lumbar spine, and its association wih pain: The research on osteoarthritis against disability (ROAD) studyP (2006)
  • Author(s): Kawaguchi H, Yoshimura N, Muraki S, Oka H, Mabuchi A, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Nakamura K
  • Organizer: OARSI 11th World Congress on Osteoarthritis
  • Place of Presentation: Prague_Czech Republic
  • Year and Date: 20061200
• [Presentation] itamin K intake is lower in knee osteoarthritispatients -A general population-based cohort study- The ROAD project (2006)
  • Author(s): Oka H, Yoshimura N, Muraki S, Mabuchi A, En-yo Y, Yoshida M, Saiga A, Kawaguchi H, Nakamura K
  • Organizer: 3rd IOF Asia-Pacific Regional Conference on Osteoporosis and 16th Annual Meeting of the Australian &New Zealand Bone & Mineral Society
  • Place of Presentation: PortDouglas-Australia
  • Year and Date: 20061000
• [Presentation] Prevalence of osteoarthritis at knee and lumbar spine in urban and rural communities: The research on osteoarthritis against disability (ROAD) study (2006)
  • Author(s): Yoshimura N, Muraki S, Oka H, Mabuchi A, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Kawaguchi H, Nakamura K
  • Organizer: Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Philadelphia-USA
  • Year and Date: 20060900
• [Presentation] Incidence and change of prevalence of vertebral fractures in a rural Japanese community: A 10-year follow-up of The Miyama Cohort (2006)
  • Author(s): Yoshimura N, Kinoshita H, Oka H, Muraki S, Kawaguchi H, Nakamura K
  • Organizer: IOF World Congress onOsteoporosis
  • Place of Presentation: Toronto-Canada
  • Year and Date: 20060600
• [Presentation] Factors associated with mortality following hip fracture (2006)
  • Author(s): Oka H, Muraki S, Yoshimura N, Yamamoto S, Kawaguchi H, Nakamura K
  • Organizer: IOF World Congress on Osteoporosis
  • Place of Presentation: Toronto-Canada
  • Year and Date: 20060600
• [Presentation] Epidemiology of osteoarthritis of the knee in arural Japanese population (2006)
  • Author(s): Oka H, Yoshimura N, Suzuki T, Yoshida H, Muraki S, Mabuchi A, Matsudaira K, Kawaguchi H, Nakamura K
  • Organizer: IOF World Congress on Osteoporosis
  • Place of Presentation: Toronto-Canada
  • Year and Date: 20060600
• [Book] 6章. 生化学的検査.マーカーによる検査. 軟骨代謝マーカー整形外科学大系2巻 (2008)
  • Author(s): 岡敬之, 川口浩
  • Total Pages: pp257-259