2008 Fiscal Year Final Research Report
Roles of the novel Akt substrate Girdin and its family of proteins in development and tumor protression
Project/Area Number |
18689904
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Experimental pathology
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Research Institution | Nagoya University |
Principal Investigator |
ENOMOTO Atsushi Nagoya University, 高等研究院, 特任講師 (20432255)
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Project Period (FY) |
2006 – 2008
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Keywords | がん / Akt / 細胞骨格 / 浸潤 / Wnt / 血管新生 |
Research Abstract |
Aktリン酸化酵素は細胞の増殖・分化にとって重要な分子であり、その異常活性化は細胞の癌化を誘導する。Aktが悪性腫瘍の浸潤や転移を促進するメカニズムの解明は治療法開発にも直結する重要課題である。近年私達が同定したAktの新規基質「Girdin」は細胞骨格の制御分子である。本研究では悪性腫瘍の進展におけるAkt/Girdinシグナル伝達系の意義を解明した。またGiridnおよびそのファミリー分子Dapleの遺伝子改変動物を作成し、生体内における各分子の意義について検討した。
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[Journal Article] Roles of induced expression of MAPK phosphatase-2 in tumor development in RET-MEN2A transgenic mice2008
Author(s)
Hasegawa T, Enomoto A, Kato T, Kawai K, Miyamoto R, Jijiwa M, Ichihara M, Ishida M, Asai N, Murakumo Y, Ohara K, Niwa Y, Goto H, Takahashi M
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Journal Title
Oncogene 27
Pages: 5684-95
Peer Reviewed
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[Journal Article] CD109 expression in basal-like breast carcinoma2008
Author(s)
Hasegawa M, Moritani S, Murakumo Y, Sato T, Hagiwara S, Suzuki C, Mii S, Jijiwa M, Enomoto A, Asai N, Ichihara S, Takahashi M
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Journal Title
Pathol Int. 58
Pages: 288-94
Peer Reviewed
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[Journal Article] GDNF-mediated signaling via RET tyrosine 1062 is essential for maintenance of spermatogonial stem cells2008
Author(s)
Jijiwa M, Kawai K, Fukihara J, Nakamura A, Hasegawa M, Suzuki C, Sato T, Enomoto A, Asai N, Murakumo Y, Takahashi M
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Journal Title
Genes Cells 13
Pages: 365-74
Peer Reviewed
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[Journal Article] An actin-binding protein Girdin regulates the motility of breast cancer cells2008
Author(s)
Jiang, P., Enomoto, A., Jijiwa, M., Kato, T., Hasegawa, T., Ishida, M., Sato, T., Asai, N., Murakumo, Y., Takahashi, M.
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Journal Title
Cancer Res. 68
Pages: 1310-8
Peer Reviewed
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[Journal Article] Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin2008
Author(s)
Kitamura, T., Asai, N., Enomoto, A., Maeda, K., Kato, T., Ishida, M., Jiang, P., Watanabe, T., Usukura, J., Kondo, T., Costantini, F., Murohara, T., Takahashi, M.
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Journal Title
Nat Cell Biol. 10
Pages: 329-37
Peer Reviewed
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[Journal Article] A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-12008
Author(s)
Suzuki, C., Murakumo, Y., Kawase, Y., Sato, T., Morinaga, T., Fukuda, N., Enomoto, A., Ichihara, M., Takahashi, M.
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Journal Title
Biochem Biophys Res Commun. 366
Pages: 226-32
Peer Reviewed
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[Journal Article] Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation2007
Author(s)
Dambara, A., Morinaga, T., Fukuda, N., Yamakawa, Y., Kato, T., Enomoto, A., Asai, N., Murakumo, Y., Matsuo, S., Takahashi, M.
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Journal Title
Exp Cell Res. 313
Pages: 3755-66
Peer Reviewed
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[Journal Article] Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate2007
Author(s)
Shin, H.J., Anzai, N., Enomoto, A., He, X., Kim, D.K., Endou, H., Kanai ,Y.
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Journal Title
Hepatology 45
Pages: 1046-55
Peer Reviewed
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[Journal Article] Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase2007
Author(s)
Ishida, M., Ichihara, M., Mii, S., Jijiwa, M., Asai, N., Enomoto, A., Kato, T., Majima, A., Ping, J., Murakumo, Y., Takahashi, M.
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Journal Title
Cancer Sci. 98
Pages: 815-21
Peer Reviewed
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[Presentation] Roles of Disrupted-In-Schizophrenia 1-Interacting Protein Girdin in Postnatal Development of the Dentate Gyrus. The American Society of Cell Biology2008
Author(s)
Enomoto, A., Asai, N., Taya, S., Tsuboi, D., Kuroda, S., Kaibuchi, K., Takahashi, M
Organizer
48th Annual Meeting
Place of Presentation
San Francisco
Year and Date
2008-12-13
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[Presentation] Characterization of the HDAC1 complex that regulates cancer cell sensitivity to oxidative stress. The American Society of Cell Biology2008
Author(s)
Kato, T., Shimono, Y., Hasegawa, M., Jijiwa, M., Enomoto, A., Asai, N., Murakumo, Y., Takahashi, M.
Organizer
48th Annual Meeting
Place of Presentation
San Francisco
Year and Date
2008-12-13
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[Presentation] Aktの新基質であるGirdinは血管新生を制御する2008
Author(s)
北村トモヤ, 浅井直也, 榎本篤, 前田健吾, 加藤琢哉, 石田麻紀, 姜平, 渡辺崇, 臼倉治郎, Frank Costantini, 室原豊明, 高橋雅英
Organizer
第67回日本癌学会学術総会
Place of Presentation
名古屋
Year and Date
2008-10-28
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