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2008 Fiscal Year Final Research Report

Roles of metabotropic glutamate receptors incross-modal plasticity in the mammalian cerebral cortex

Research Project

  • PDF
Project/Area Number 18700317
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionKyoto University

Principal Investigator

TAGAWA Yoshiaki  Kyoto University, 大学院・理学研究科, 助教 (50303813)

Project Period (FY) 2006 – 2008
Keywords大脳皮質 / グルタミン酸受容体 / 発達 / 可塑性 / 神経活動 / 神経ネットワーク
Research Abstract

脳発達期の正確な神経回路網形成には、遺伝的プログラムと神経活動の両者の働きが必須である。本研究では、神経活動に依存した脳の回路発達・可塑性メカニズムの解明をめざした。実験動物(マウス)の大脳皮質内神経回路の解剖学的・機能的なつながり(神経連絡パターン)とその発達過程を詳細に可視化する新たな実験系を確立した。さらに、その発達過程にシナプス前・後細胞の神経活動が重要な役割を担うことを明らかにした。

  • Research Products

    (10 results)

All 2008 2007 2006 Other

All Journal Article (2 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] Activity-dependent development of interhemispheric connections in the visual cortex.2008

    • Author(s)
      Tarawa Y. Mizuno H, Hirano T.
    • Journal Title

      Reviews in the Neurosciences 19

      Pages: 19-28

  • [Journal Article] Evidence for activity-dependent cortical wiring : Formation of interhemispheric connections in neonatal mouse visual cortex requires projection neuron activity2007

    • Author(s)
      Mizuno H, Hirano T, & Tarawa Y.
    • Journal Title

      The Journal of Neuroscience 27(25)

      Pages: 6760-6770

  • [Presentation] Differential effects of presynaptic and postsynaptic activity-blockade on interhemispheric connection development in mouse cerebral cortex.2008

    • Author(s)
      Mizuno H, Hirano T, & Tagawa Y.
    • Organizer
      38^<th> Annual Meeting, Society for Neuroscience
    • Place of Presentation
      Washington D.C.
    • Year and Date
      2008-11-16
  • [Presentation] Activity-dependent cortical wiring in vivo : Formation of interhemispheric connections requires presynaptic and postsynaptic neuron activity2008

    • Author(s)
      Tagawa Y, Mizuno H, Hirano T
    • Organizer
      第31回日本神経科学大会ワークショップ
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
  • [Presentation] Activity-dependent development of interhemispheric connections in mouse visual cortex.2008

    • Author(s)
      Mizuno H, Hirano T, & Tagawa Y.
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
  • [Presentation] Formation of interhemispheric connections in neonatal mouse visual cortex requires projection neuron activity.2007

    • Author(s)
      Mizuno H, Hirano T, & Tagawa Y.
    • Organizer
      37^<th> Annual Meeting, Society for Neuroscience
    • Place of Presentation
      San Diego
    • Year and Date
      2007-11-04
  • [Presentation] Roles of pre- and postsynaptic neuron activity in interhemispheric connection development in the mouse visual cortex.2007

    • Author(s)
      Mizuno H, Hirano T, & Tagawa Y.
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-10
  • [Presentation] Activity-dependent development of interhemispheric connections in mouse visual cortex.2006

    • Author(s)
      Mizuno H, Hirano T, & Tagawa Y.
    • Organizer
      第35回生理研・統合脳国際シンポジウム
    • Place of Presentation
      岡崎
    • Year and Date
      2006-07-25
  • [Presentation] Activity-dependent development of interhemispheric connections in mouse visual cortex.2006

    • Author(s)
      Mizuno H, Hirano T, & Tagawa Y.
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Year and Date
      2006-07-20
  • [Remarks]

    • URL

      http://www.biophys.kyoto-u.ac.jp/hirano.php

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Published: 2010-06-10   Modified: 2016-04-21  

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