Development of field-effect based glucose sensors using a ZnMgO alloy

2008 Fiscal Year Final Research Report

• Project/Area Number: 18760310
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Measurement engineering
• Research Institution: Osaka Institute of Technology
• Principal Investigator: KOIKE Kazuto Osaka Institute of Technology, 工学部, 准教授 (40351457)
• Project Period (FY): 2006 – 2008
• Keywords: 酸化マグネシウム亜鉛 / 酸化亜鉛 / グルコースセンサ / バイオセンサ / 電界効果トランジスタ / グルコース酸化酵素

Research Abstract

65歳以上の人口が国内総人口の1/5を占める今日,生活習慣病を煩う患者数が年々増加の一途をたどっている.特に糖尿病患者の割合が大きく深刻な社会問題となっている.この問題を解決するため本研究では,微量の血液で血糖値を手軽に検出できる電界効果型グルコースセンサ(血糖値センサ)の開発を行った.センサの母体材料には生体適合性の高い酸化マグネシウム亜鉛を用い,グルコースの検出にはグルコース酸化酵素を用いた.最終的に,グルコースに対する検出速度が20秒以下,検出可能範囲が0〜5mg/cm3のセンサを開発することに成功した.

Research Products

• [Journal Article] Characteristics of an enzyme-based ZnO/Zn0.7Mg0.3O heterojunction field-effect transistor as glucose sensor (2009)
  • Author(s): Kazuto Koike, Daisuke Takagi, Mitsuhiro Hashimoto, Takahito Hashimoto, Tomoyuki Inoue, Ken-ichi Ogata, Shigehiko Sasa, Masataka Inoue, Mitsuaki Yano
  • Journal Title: Japanese Journal of Applied Physics 48 Pages: 04C081-4
  • Peer Reviewed
• [Journal Article] 高移動度ZnO/ZnMgO電界効果トランジスタとバイオセンサ応用 (2008)
  • Author(s): 小池一歩
  • Journal Title: 応用物理 77 Pages: 296-300
  • Peer Reviewed
• [Journal Article] Ion-sensitive characteristics of an electrolyte-solution-gate ZnO/ZnMgO heterojunction field-effect transistor as a biosensing transducer (2007)
  • Author(s): Kazuto Koike, Daisuke Takagi, Motoki Kawasaki, Takahito Hashimoto, Tomoyuki Inoue, Ken-ichi Ogata, Shigehiko Sasa, Masataka Inoue, Mitsuaki Yano
  • Journal Title: Japanese Journal of Applied Physics 46 Pages: L865-L867
  • Peer Reviewed
• [Presentation] Characteristics of an enzyme-based ZnO/Zn0.7Mg0.3O heterojunction fieldeffect transistor as a glucose sensor (2008)
  • Author(s): Kazuto Koike, Daisuke Takagi, Mitsuhiro Hashimoto, Takahito Hashimoto, Tomoyuki Inoue, Ken-ichi Ogata, Shigehiko Sasa, Masataka Inoue, Mitsuaki Yano
  • Organizer: 2008 International Conference on Solid State Devices and Materials
  • Place of Presentation: Ibaraki, Japan
  • Year and Date: 2008-09-26
• [Presentation] Electrolyte gate ZnO/ZnMgOfield effect transistors as pH sensors (2007)
  • Author(s): Kazuto Koike, Daisuke Takagi, Motoki Kawasaki, Yoshinobu Nakamura, Yoshiaki Hirano, Shigehiko Sasa, Masataka Inoue, Mitsuaki Yano
  • Organizer: The 13th International Conference onII-VI Compounds
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2007-09-11
• [Presentation] pH response of a surface-modified ZnO/ZnMgOfield-effect transistor in an electrolyte solution (2007)
  • Author(s): Kazuto Koike, Daisuke Takagi, Shigehiko Sasa, Yoshiaki Hirano, Yoshinobu Nakamura, Masataka Inoue, Mitsuaki Yano
  • Organizer: 2007 International Meeting for Future of Electron Devices
  • Place of Presentation: Kansai, Osaka
  • Year and Date: 2007-04-24
• [Book] 「酸化亜鉛系トランジスタとその応用」,八百編:ZnO系の最新技術と応用 (2007)
  • Author(s): 佐々誠彦,小池一歩,前元利彦,矢野満明,井上正崇
  • Total Pages: 103-130
  • Publisher: シーエムシー出版
• [Remarks]
  • URL: http://www.oit.ac.jp/japanese/nanotech/