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2008 Fiscal Year Final Research Report

Control mechanism of Th1/Th2 balance in fish

Research Project

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Project/Area Number 18780151
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General fisheries
Research InstitutionKagoshima University (2007-2008)
Nihon University (2006)

Principal Investigator

ARAKI Kyosuke  Kagoshima University, 水産学部, 助教 (30409073)

Project Period (FY) 2006 – 2008
Keywordsクローンギンブナ / トラフグ / Th1 / Th2 / T細胞 / 細胞性免疫 / サイトカイン / 転写因子 / モノクローナル抗体
Research Abstract

養殖魚類における疾病の発生を防ぐためにはワクチンが最も有効な手段であるが、その開発は難航している。魚類の免疫システムの理解が不足しているためである。そこで本研究では魚類のヘルパーT細胞やキラーT細胞を同定するツールを作製し、またT細胞が産生する免疫関連因子の遺伝子を多数明らかにした。さらにこれらツールを用いて、未だワクチンが開発されていない疾病の原因細菌に対する感染防御機構を分子レベルで解析した。これらの成果は魚類のワクチン開発を飛躍的に発展させるものである。

  • Research Products

    (23 results)

All 2008 2007

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (14 results)

  • [Journal Article] Characterization of CD8+ leukocytes in fugu (Takifugu rubripes) with antiserum against fugu CD8 alpha2008

    • Author(s)
      Araki K., Akatsu K., Suetake H., Kikuchi K and Y. Suzuki
    • Journal Title

      Dev. Comp. Immunol 32

      Pages: 850-853

    • Peer Reviewed
  • [Journal Article] GATA3 mRNA in ginbuna crucian carp (Carassius auratus langsdorfii) : cDNA cloning, splice variant and expression analysis2008

    • Author(s)
      Takizawa F., Mizunaga Y., Araki K., Moritomo T., Ototake M. and T. Nakanishi
    • Journal Title

      Dev. Comp. Immunol 32

      Pages: 898-907

    • Peer Reviewed
  • [Journal Article] Characterization and localization of side population (SP) cells in Zebrafish kidney hematopoietic tissue2008

    • Author(s)
      Kobayashi I., Saito K., Moritomo T., Araki K., Takizawa F. and T. Nakanishi
    • Journal Title

      Blood 111

      Pages: 1131-1137

    • Peer Reviewed
  • [Journal Article] Characterization of teleost phagocyte NADPH oxdase ? Molecular cloning and expression analysis of carp (Cyprinus carpio) phagocyte NADPH oxidase-2008

    • Author(s)
      Mayumi M., Takeda Y., Hoshiko M., Serada K., Murata M., Moritomo T., Takizawa F., Kobayashi I., Araki K., Nakanishi T. and H. Sumimoto
    • Journal Title

      Mol. Immunol 45

      Pages: 1720-1731

    • Peer Reviewed
  • [Journal Article] Molecular cloning and expression analysis of T-bet in ginbuna crucian carp (Carassius auratus langsdorfii)2008

    • Author(s)
      Takizawa F., Araki K., Kobayashi I., Moritomo T., Ototake M. and T. Nakanishi
    • Journal Title

      Mol. Immunol 45

      Pages: 127-136

    • Peer Reviewed
  • [Journal Article] Suzuki, Description of a fugu CXC chemokine and two CXC receptor genes, and characterization of the effect of different stimulators on their expression2007

    • Author(s)
      Saha N. R., Bei J. X., Suetake H., Araki K., Kai W., Kikuchi K., Lin H. R. and Y. Suzuki
    • Journal Title

      Fish Shellfish Immunol 23

      Pages: 1324-1332

    • Peer Reviewed
  • [Journal Article] Expression and genetic organization of fugu CD8 alpha and CD8 beta genes in fugu, Takifugu rubripes2007

    • Author(s)
      Suetake H., Araki K., Akatsu K., Somamoto T., Dijkstra J.M., Yoshiura Y., Kikuchi K. and Y. Suzuki
    • Journal Title

      Fish Shellfish Immunol 23

      Pages: 1107-1118

    • Peer Reviewed
  • [Journal Article] Identification and Characterization of multiple Lck genes in ginbuna crucian carp2007

    • Author(s)
      Araki K., Hirano K., Takizawa F., Moritomo T., Ototake M. and T. Nakanishi
    • Journal Title

      Carassius auratus langsdorfii. Fish. Sci 73

      Pages: 1017-1024

    • Peer Reviewed
  • [Journal Article] Expression analysis of two Eomesodermin homologues in zebrafish lymphoid tissues and cells2007

    • Author(s)
      Takizawa F., Araki K., Ito K., Moritomo M. and T. Nakanishi
    • Journal Title

      Mol. Immunol 44

      Pages: 2324-2331

    • Peer Reviewed
  • [Presentation] changes and expression profile of immune-related genes induced by Spring Viremia of Carp Virus A1 in Zebrafish, Danio rerio2008

    • Author(s)
      Sun J. J., Ouyang Z. L., Araki K., Huang X. H., Nakanishi T. and Q. W. Qin
    • Organizer
      5th World Fisheries Congress
    • Place of Presentation
      横浜
    • Year and Date
      20081000
  • [Presentation] Characterization of tiger puffer Takifugu rubripes (fugu) CD4+ and CD8+ leukocytes2008

    • Author(s)
      Suetake H., Araki K., Kikuchi K. and Y. Suzuki
    • Organizer
      5th World Fisheries Congress
    • Place of Presentation
      横浜
    • Year and Date
      20081000
  • [Presentation] Co-culture of carp (Cyprinus carpio) kidney hematopoietic cells with feeder layer resulted in long-term proliferation of T cell lineages2008

    • Author(s)
      Katakura F., Takizawa F., Yoshida M.,Yamaguchi T., Araki K., Moritomo T. And T. Nakanishi
    • Organizer
      5th World Fisheries Congress
    • Place of Presentation
      横浜
    • Year and Date
      20081000
  • [Presentation] Molecular cloning and expression analysis of two Eomes genes in ginbuna crucian carp (Carassius auratus langsdorfii)2008

    • Author(s)
      Takizawa F., Araki K., Toda H., Ohtani M., Moritomo T., Ototake M. and T. Nakanishi
    • Organizer
      5th World Fisheries Congress
    • Place of Presentation
      横浜
    • Year and Date
      20081000
  • [Presentation] Interferon-gamma and perforin correlate with cell-mediated immunity in ginbuna crucian carp Carassius auratus langsdorfii2008

    • Author(s)
      Araki K., Takizawa F., Esumi M., Konishi M., Moritomo T., Ototake M. and T. Nakanishi
    • Organizer
      5th World Fisheries Congress
    • Place of Presentation
      横浜
    • Year and Date
      20081000
  • [Presentation] Production and characterization of monoclonal antibodies against CD4 and CD8・in clonal ginbuna crucian carp Carassius auratus langsdorfii2008

    • Author(s)
      Nakanishi T., Saito Y., Koike T., Toda H., Takizawa F., Araki K., Somamoto T., Suetake H., Suzuki Y., Ototake M. and T. Moritomo
    • Organizer
      5th World Fisheries Congress
    • Place of Presentation
      横浜
    • Year and Date
      20081000
  • [Presentation] トラフグのヘルパーT細胞、平成19年度2007

    • Author(s)
      末武弘章・赤津可南子・松永貴芳・荒木亨介・菊池潔・鈴木譲
    • Organizer
      日本魚病学会大会
    • Place of Presentation
      函館
    • Year and Date
      2007-09-29
  • [Presentation] ギンブナCD4に対するモノクローナル抗体の特性解明、日本比較免疫学会2007

    • Author(s)
      齋藤泰孝・瀧澤文雄・荒木亨介・戸田秀明・杣本智軌・末武弘章・鈴木譲・乙竹充・森友忠昭・中西照幸
    • Organizer
      第19回学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2007-08-22
  • [Presentation] トラフグIL-2の発現・機能解析、日本比較免疫学会2007

    • Author(s)
      三浦正晴・末武弘章・荒木亨介・吉浦康寿・菊池潔・鈴木譲
    • Organizer
      第19回学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2007-08-21
  • [Presentation] ギンブナPerforin遺伝子におけるアイソタイプの構造及び発現解析、日本比較免疫学会2007

    • Author(s)
      小西麻理子・荒木亨介・瀧澤文雄・乙竹充・森友忠昭・中西照幸
    • Organizer
      第19回学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2007-08-21
  • [Presentation] コイ好中球の炎症部位におけるNADPH酸化酵素遺伝子の発現変化2007

    • Author(s)
      世良田研・森友忠昭・小林功・荒木亨介・中西照幸
    • Organizer
      第18回日本生体防御学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2007-07-26
  • [Presentation] ゼブラフィッシュ腎臓におけるside population(SP)細胞の同定と局在2007

    • Author(s)
      小林功・森友忠昭・荒木亨介・瀧澤文雄・中西照幸
    • Organizer
      第40回日本発生生物学会・第59回日本細胞生物学会合同大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-30
  • [Presentation] ギンブナGATA3遺伝子のcDNAクローニング及び発現解析2007

    • Author(s)
      瀧澤文雄・水永夕葉・荒木亨介・森友忠昭・乙竹充・中西照幸
    • Organizer
      平成19年度日本水産学会春季大会
    • Place of Presentation
      東京
    • Year and Date
      2007-03-30
  • [Presentation] ギンブナIFN-・アイソタイプの細胞性免疫への関与2007

    • Author(s)
      荒木亨介・江角真梨子・佐藤匡浩・瀧澤文雄・森友忠昭・乙竹充・中西照幸
    • Organizer
      平成19年度日本水産学会春季大会
    • Place of Presentation
      東京
    • Year and Date
      2007-03-30

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Published: 2010-06-10   Modified: 2016-04-21  

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