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2008 Fiscal Year Final Research Report

Establishment of consomic mice to clarify host susceptibility to caries

Research Project

  • PDF
Project/Area Number 18791567
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionNihon University

Principal Investigator

SHIMIZU Kunihiko  Nihon University, 松戸歯学部, 講師 (30328760)

Project Period (FY) 2006 – 2008
Keywords実験動物 / マウス / コンソミックマウス / 第2番染色体 / う蝕 / C57BL / 6 / C3H
Research Abstract

C57BL/6系統(齲蝕高感受性マウス)由来の全染色体のうち第2番染色体をC3H/He系統(齲蝕低感受性マウス)に置き換えたコンソミックマウスB6-Chr.2C3Hの作成を行った。マウスの兄妹交配と第2番染色体の組み換え状態の確認を12世代まで行い,この世代の兄妹交配によりコンソミックマウスB6-Chr.2C3Hを得たことにより,マウス第2番染色体に存在する齲蝕発症に関わる原因遺伝子の解明が可能となった。

  • Research Products

    (2 results)

All 2009 2008

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Establishment of consomic mice to clarify host susceptibility to caries2009

    • Author(s)
      Makoto Nomi, Kunihiko Shimizu
    • Journal Title

      Pediatric Dental Journal 19

      Pages: (掲載予定)

    • Peer Reviewed
  • [Presentation] Establishment of comsomic mice to clarify host susceptibility to caries2008

    • Author(s)
      Makoto Nomi, Kunihiko Shimizu, Daisuke Orino, Atsuko Nagata, Nana Ikematsu, Wataru Morita, Takahide Maeda
    • Organizer
      Internal association for dental research
    • Place of Presentation
      Toronto Canada.
    • Year and Date
      20080602-05

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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