2008 Fiscal Year Final Research Report
Analysis of interaction between botulinum neurotoxin type D and Phosphatidylethanolamine
Project/Area Number |
18799011
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Bacteriology (including Mycology)
|
Research Institution | Fujita Health University |
Principal Investigator |
TSUKAMOTO Kentaro Fujita Health University, 医学部, 助教 (80434596)
|
Project Period (FY) |
2006 – 2008
|
Keywords | Clostridium botulinum / ボツリヌス毒素 / 受容体 / ガングリオシド / ホスファチジルエタノールアミン / 表面プラズモン共鳴 |
Research Abstract |
ボツリヌス神経毒素(A〜G型)は型特異的な受容体に結合する。そのうち、ボツリヌスD型毒素は他の型とは異なり、グリセロリン脂質の一つPEに結合する。本研究では、ボツリヌスD型神経毒素とPEの分子間相互作用について調べ、毒素分子内のPE認識に関わるアミノ酸残基を特定した。さらに表面プラズモン共鳴による結合解析の実験系を構築し、蛋白質-脂質の分子間相互作用について定量的に解析することを可能にした。
|
Research Products
(10 results)
-
[Journal Article] Identification of the receptor-binding sites in the carboxyl-terminal half of the heavy chain of botulinum neurotoxin types C and D2008
Author(s)
Tsukamoto, K., Kozai, Y., Ihara, H., Kohda, T., Mukamoto, M., Tsuji, T. and Kozaki, S.
-
Journal Title
Microb Pathog 44
Pages: 484-493
Peer Reviewed
-
[Journal Article] A nasal vaccine comprising B-subunit derivative of Shiga toxin 2 for cross-protection against Shiga toxin types 1 and 22008
Author(s)
Tsuji, T., Shimizu, T., Sasaki, K., Tsukamoto, K., Arimitsu, H., Ochi, S., Taniguchi, K., Noda, M., Neri, P. and Mori, H.
-
Journal Title
Vaccine 26
Pages: 2092-2099
Peer Reviewed
-
[Journal Article] Protection of mice from Shiga toxin-2 toxemia by mucosal vaccine of Shiga toxin 2B-His with Escherichia coli enterotoxin2008
Author(s)
Tsuji, T., Shimizu, T., Sasaki, K., Shimizu, Y., Tsukamoto, K., Arimitsu, H., Ochi, S., Sugiyama, S., Taniguchi, K., Neri, P. and Mori, H.
-
Journal Title
Vaccine 26
Pages: 469-476
Peer Reviewed
-
[Journal Article] Molecular properties of each subcomponent in Clostridium botulinum type B haemagglutinin complex2008
Author(s)
Arimitsu, H., Sakaguchi, Y., Lee, J. C., Ochi, S., Tsukamoto, K., Yamamoto, Y., Ma, S., Tsuji, T. and Oguma, K.
-
Journal Title
Microb Pathog 45
Pages: 142-149
Peer Reviewed
-
-
-
-
-
-