2019 Fiscal Year Annual Research Report
ヒトｉＰＳ肝芽再構成系を用いた血液細胞との相互作用により肝細胞分化制御機構の解明
| Project/Area Number |
18F18101
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| Research Institution | Yokohama City University |
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Principal Investigator |
谷口 英樹 横浜市立大学, 医学研究科, 教授 (70292555)
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| Co-Investigator(Kenkyū-buntansha) |
NIE YUNZHONG 横浜市立大学, 医学(系)研究科(研究院), 外国人特別研究員
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| Project Period (FY) |
2018-04-25 – 2020-03-31
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| Keywords | hiPSC / Organoid / Hepatocyte / Hematopoietic cells / Cell-cell interactions / Liver disease / Liver organogenesis / CD14 |
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| Outline of Annual Research Achievements |
In this study, we are going to understand how the dynamic interactions between hematopoietic and hepatic cells regulate liver development, and to generate the functional liver organoid that can be used for liver disease study and model. For this purpose, we try to establish an organoid to recapitulate hematopoietic-hepatic interactions during early liver organogenesis. Based on the developed hematopoietic-hepatic organoid, we have recapitulated the hepatic-hematopoietic symbiotic relationship. In the last year, we revealed the molecular mechanism of this symbiotic relationship. Monocyte is differentiated into M2 macrophage in the hepatic microenvironment, and the monocyte step-wisely promotes organoid development.
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| Research Progress Status |
令和元年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和元年度が最終年度であるため、記入しない。
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