2019 Fiscal Year Annual Research Report
High-throughput, single-cell optofluidic platform for point-of-care diagnosis
Project/Area Number |
18F18716
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Research Institution | The University of Tokyo |
Principal Investigator |
合田 圭介 東京大学, 大学院理学系研究科(理学部), 教授 (70518696)
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Co-Investigator(Kenkyū-buntansha) |
YAN SHENG 東京大学, 理学(系)研究科(研究院), 外国人特別研究員
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Project Period (FY) |
2018-10-12 – 2021-03-31
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Keywords | Optofluidics / imaging flow cytometry |
Outline of Annual Research Achievements |
Two breakthrough technologies are generated with the completion of this project. The first one is intelligent platelet aggregate classifier (iPAC) that performs high-throughput imaging and intelligent analysis of platelet aggregates produced by different agonists and classifies platelet aggregates by agonist type. Our finding that platelet aggregates can be classified by agonist type through their morphology is unprecedented as it has never been reported previously. The information about the driving factors behind the formation of platelet aggregates is expected to lead to a better understanding of the underlying mechanism of platelet aggregation and open a window on an entirely new class of clinical diagnostics, pharmacometrics, and therapeutics. The second one is the virtual optofluidic time-stretch quantitative phase imaging, which generates “virtual” phase images from their corresponding bright-field images by using a deep neural network trained with numerous pairs of bright-field and phase images and identifies cancer cells from white blood cells based on their bright-field and virtual phase images. The fellow, Dr Yan, has presented his work in a prestigious international conference (Australia and New Zealand Nanofluidics and Microfluidics conference). Meanwhile, 3 manuscripts are generated from this project.
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Research Progress Status |
翌年度、交付申請を辞退するため、記入しない。
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Strategy for Future Research Activity |
翌年度、交付申請を辞退するため、記入しない。
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[Journal Article] Intelligent frequency-shifted optofluidic time-stretch quantitative phase imaging2020
Author(s)
2.Yunzhao Wu, Yuqi Zhou, Chun-Jung Huang, Hirofumi Kobayashi, Sheng Yan, Yasuyuki Ozeki, Yingli Wu, Chia-Wei Sun, Atsushi Yasumoto, Yutaka Yatomi, Cheng Lei, Keisuke Goda
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Journal Title
Optics Express
Volume: Vol. 28, Issue 1
Pages: 519-532
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Intelligent classification of platelet aggregates by agonist type2020
Author(s)
3.Yuqi Zhou, Atsushi Yasumoto, Cheng Lei, Chun-Jung Huang, Hirofumi Kobayashi, Yunzhao Wu, Sheng Yan, Chia-Wei Sun, Yutaka Yatomi, Keisuke Goda
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Journal Title
eLife
Volume: 9, e52938
Pages: -
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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