2018 Fiscal Year Annual Research Report
量子ドットによる新規セラノスティックナノ粒子の開発
| Project/Area Number |
18F18766
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
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Principal Investigator |
青木 伊知男 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, 統括グループリーダー(定年制常勤) (10319519)
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| Co-Investigator(Kenkyū-buntansha) |
SEMKOVA SEVERINA 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, 外国人特別研究員
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| Project Period (FY) |
2018-10-12 – 2020-03-31
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| Keywords | redox / MRI / EPR / quantum dots |
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| Outline of Annual Research Achievements |
Development of new theranostic nanoparticles, based on quantum dots (QDs), conjugated with multispin nitroxide-cyclodextrins for quantitative imaging assays of oxidative stress and redox-status of living cells and tissues. These nanoparticles will combine several features: 1) three imaging modalities (MRI, EPR, optical); 2) intracellular delivery and localization mainly into the mitochondria; 3) possibility to sense and visualize the areas of oxidative stress and redox-status in living cells and tissues; due to dynamics of their contrast properties, based on the balance between oxidizers and reducers; 4) redox-modulating activity and possibility to induce apoptosis in cancer cells, without significant effect on viability of normal cells; due to SOD-mimetic feature of nitroxide residue.
1. I synthesized and characterized of two quantum sensors using DLS, fluorescence spectroscopy, EPR spectroscopy, MRI on phantoms. I evaluated redox-sensitivity in model chemical systems.
2. I prepared MRI preclinical research environment.
3. I prepared cell and chemical research environment.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
計画通り進行している。
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| Strategy for Future Research Activity |
計画通り進行する。
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