Ontogeny and phylogeny of head development

2008 Fiscal Year Self-evaluation Report

• Project/Area Number: 18GS0320
• Research Category: Grant-in-Aid for Creative Scientific Research
• Allocation Type: Single-year Grants
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: 相沢 慎一 The Institute of Physical and Chemical Research, ボディプラン研究グループ, グループディレクター (60073011)
• Project Period (FY): 2006 – 2010
• Keywords: 頭部ギャップ遺伝子 / エンハンサー / 系統発生 / 胚体外組織 / 前後軸形成 / 頭部誘導 / 脳領域化 / 皮質形成

Research Abstract

現在なお、脊椎動物の起源、門レベルの進化を解明する道筋はない。しかし、各脊椎動物での分子発生学的解析の進捗とゲノム情報の進捗によって、綱レベルでの脊椎動物の体造りの変化を解明する時点に達した。脊椎動物の頭部は脳と神経堤細胞のつくる頭蓋によって特徴づけられ、これに比する構造は原索動物には存在しない。脊椎動物にのみ特有な頭部はまた脊椎動物進化の過程で最も劇的に変遷した構造で、生物体最高の所産であるヒト新皮質を生み出した。本研究は頭部形成の各段階で主要な役割を果たす頭部ギャップ遺伝子について、各発現を制御するシスエレメントを中核に、上流因子、協働因子、下流因子を含めた遺伝子カスケードの変化として脊椎動物の頭部進化を明らかにする。

Research Products

• [Journal Article] Evolution of Otx paralogue usages in early patterning of the vertebrate head (2009)
  • Author(s): Suda, Y., Kurokawa, D., Takeuchi, M.,Kajikawa, E., Kuratani, S., Amemiya, C.and Aizawa, S
  • Journal Title: Developmental Biology 325 Pages: 282-295
  • Peer Reviewed
• [Journal Article] Experience-Dependent Transfer of Otx2 Homeoproteininto the visual Cortex Activates PostnatalPlasticity (2008)
  • Author(s): Sugiyama, S., Nardo, AD., Aizawa, S.,Matsuo, I., Volovitch, M., Prochiantz, A. and Hensch, TK
  • Journal Title: Cell 134 Pages: 208-520
  • Peer Reviewed
• [Journal Article] EPB41L5functions to post-transcriptionallyregulate cadherin and integrin duringepithelial- mesenchymal transition (2008)
  • Author(s): Hirano, M., Hashimoto, S., Yonemura, S.,Sabe, H. and Aizawa, S
  • Journal Title: Journal of Cell Biology 182 Pages: 1217-1230
  • Peer Reviewed
• [Journal Article] differentiation by suppressing Foxg1 expression in mousemedial pallium (2008)
  • Author(s): Shibata, M., Kurokawa, D., Nakao, H.,Ohmura, T. and Aizawa, S
  • Journal Title: J Neurosci 28 Pages: 10415-21
  • Peer Reviewed
• [Journal Article] Semaphorin 3F confines ventral tangential migration oflateral olfactory tract neurons onto the telencephalonsurface (2008)
  • Author(s): K Ito, T Kawasaki, S Takashima, I Matsuda, A Aiba, and T Hirata
  • Journal Title: J. Neurosci 28 Pages: 4414-4422
  • Peer Reviewed
• [Journal Article] Acetylated YY1 regulates Otx2 expressioninanterior neuroectoderm attwo cis-sites 90kbapart (2007)
  • Author(s): Takasaki, N., Kurokawa, D., Nakayama, R., Nakayama, J. and Aizawa, S
  • Journal Title: The EMBO Journal 26 Pages: 1649-1659
  • Peer Reviewed
• [Journal Article] Mouse homologues of Shisa antagonistic to Wnt and Fgfsignalings (2007)
  • Author(s): Furushima, K., Yamamoto, A., Nagano,T., Shibata, M., Miyachi, H. and Abe, T., Ohshima, N., Kiyonari, H., Aizawa, S
  • Journal Title: Developmental Biology 306 Pages: 480-492
  • Peer Reviewed
• [Journal Article] Evolutionary constraint on Otx2 neuroectodermenhacers-deep conservation from skate to mouse and uniquedivergence in teleost (2006)
  • Author(s): Kurokawa, D., Sakurai, Y., Inoue, A., Nakayama, R., Takasaki, N., Suda, Y., Miyake, T., Amemiya, C. and Aizawa, S
  • Journal Title: Proc. Natl. Acad. Sci. USA 103 Pages: 19350-19355
  • Peer Reviewed