2020 Fiscal Year Final Research Report

Learning and recovery mechanism of posture control in the cerebellum

Research Project

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Project/Area Number	18H01393
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 20010:Mechanics and mechatronics-related
Research Institution	The University of Electro-Communications
Principal Investigator	Funato Tetsuro 電気通信大学, 大学院情報理工学研究科, 准教授 (40512869)
Co-Investigator(Kenkyū-buntansha)	柳原大東京大学, 大学院総合文化研究科, 教授 (90252725) 青井伸也京都大学, 工学研究科, 准教授 (60432366) 藤木聡一朗獨協医科大学, 医学部, 講師 (90770173) 四津有人東京大学, 大学院工学系研究科, 准教授 (30647368)
Project Period (FY)	2018-04-01 – 2021-03-31
Keywords	姿勢制御 / 予期的姿勢調節 / 小脳 / 学習 / モデル予測制御
Outline of Final Research Achievements	The principle of postural control with learning in the cerebellum was approached through measurements of standing motion in rats and patients with cerebellar disorders, disturbance learning experiments in standing rats, and mathematical modeling. The nonlinear control system in rats with lesion in the inferior olivary nuclei and the integral control function in patients with cerebellar ataxia were impaired, both suggesting a decrease in predictive control function due to impaired internal model learning. A posture control model based on the internal model was constructed and evaluated by comparison with the results of disturbance learning of standing rats. The results showed that the postural control with learning in the cerebellum can be explained by the predictive control based on the internal model.
Free Research Field	システム工学、制御工学、バイオメカニクス
Academic Significance and Societal Importance of the Research Achievements	小脳における障害は姿勢維持機能の低下を生じ、歩行や直立の動作機能に影響を与える。小脳障害に伴う姿勢維持機能の低下と回復原理が解明できれば、効果的なリハビリテーション法の構築につながる。本研究の結果、小脳系の障害に伴う姿勢機能の低下、及び学習による姿勢機能の構築を説明する、内部モデルを用いた制御系のシステムモデルが構築された。本モデルは小脳における運動学習と回復メカニズムの幅広い研究に応用ができ、モデルに基づくリハビリテーション法の構築につながると期待できる。