2020 Fiscal Year Final Research Report

Ultra-sensitive real-time MRS probe using high-field MRI

Research Project

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Project/Area Number	18H01841
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 28050:Nano/micro-systems-related
Research Institution	Tottori University (2019-2020) Tohoku University (2018)
Principal Investigator	MATSUNAGA Tadao 鳥取大学, 工学部, 准教授 (00396540)
Co-Investigator(Kenkyū-buntansha)	吉岡芳親大阪大学, 生命機能研究科, 特任教授(常勤) (00174897) 芳賀洋一東北大学, 医工学研究科, 教授 (00282096) 藤原俊朗岩手医科大学, 医学部, 助教 (60405842) 鶴岡典子東北大学, 工学研究科, 助教 (70757632)
Project Period (FY)	2018-04-01 – 2021-03-31
Keywords	MRI / MRS / MEMS / リアルタイムバイオイメージング / 非平面微細加工技術
Outline of Final Research Achievements	An intraluminal magnetic resonance imaging (MRI) probe holds promise to achieve a higher resolution image of a small pathological lesion than conventional external probes. Such an intraluminal probe requires precise resonant frequency tuning to 500 MHz and impedance matching to 50 Ω, if used for instance in a 11.7-T scanner which can realize a real-time bio-imaging. Designed coil which has higher self-resonance frequency has been fabricated utilizing our developed non-planar photofabrication techniques, and an electrical characteristic has been evaluated. Measured self-resonant frequency of the MRI coil was around 800 MHz and it is higher enough to realize a higher resolution MRI.
Free Research Field	医工学
Academic Significance and Societal Importance of the Research Achievements	当該研究により実現できる超高分解能なMRIはこれまで解明できていない体内深部における早期がんの発見につながるだけでなく、生体の神経活動などリアルタイムバイオイメージングの実現にもつながる。この様に医療デバイスだけでなく、生体内部における生理学的な減少を解明する取組であり、非平面微細加工技術や小型実装技術がブレークスルー技術である。