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2020 Fiscal Year Annual Research Report

Development of practical application of combination therapy against piroplasmosis in animals

Research Project

Project/Area Number 18H02337
Research InstitutionObihiro University of Agriculture and Veterinary Medicine

Principal Investigator

五十嵐 郁男  帯広畜産大学, 原虫病研究センター, 名誉教授 (80159582)

Co-Investigator(Kenkyū-buntansha) 横山 直明  帯広畜産大学, 原虫病研究センター, 教授 (80301802)
Project Period (FY) 2018-04-01 – 2021-03-31
Keywordsピロプラズマ病 / 新規治療 / コンビネーション療法
Outline of Annual Research Achievements

マウスモデルの実験結果に基づいて、モンゴルでの家畜を用いた治療効果の検証を計画した。研究協力者と、家畜の種類、頭数、年齢、感染に用いる家畜の輸送や管理、用いる薬剤の選定、価格の調査、入手法、モンゴルへの輸送、通関手続き、家畜への投与量、投与方法、さらに観戦実験に用いる原虫の準備、感染実験に用いる原虫の準備、接種方法、評価項目、検査方法、サンプル採取のスケジュール作成、実験に協力者への謝礼などについて打ち合わせを行った。その結果、コロカ禍の影響による、用いる薬剤の十分な在庫不不足、治療に用いる薬剤の必要量の計算結果が当初予想量よりもはるかに高く、予算内のでの購入が困難であることが判明した。

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

  • Research Products

    (11 results)

All 2023 2022

All Journal Article (11 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 11 results,  Open Access: 4 results)

  • [Journal Article] Animal models of the immunology and pathogenesis of human babesiosis2023

    • Author(s)
      Kumar Abhinav、Kabra Aditya、Igarashi Ikuo、Krause Peter J.
    • Journal Title

      Trends in Parasitology

      Volume: 39 Pages: 38~52

    • DOI

      10.1016/j.pt.2022.11.003

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Imidazo[1,2-a]pyridine: a Highly Potent Therapeutic Agent Clears Piroplasm Infection In Vitro2023

    • Author(s)
      Rizk Mohamed Abdo、El-Sayed Shimaa Abd El-Salam、El-Alfy El-Sayed、Igarashi Ikuo
    • Journal Title

      Acta Parasitologica

      Volume: 68 Pages: 249~256

    • DOI

      10.1007/s11686-022-00655-w

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of a promising antigenic cocktail for the global detection of Babesia caballi in horse by ELISA2023

    • Author(s)
      El-Sayed Shimaa Abd El-Salam、Rizk Mohamed Abdo、Baghdadi Hanadi B.、Ringo Aaron Edmond、Sambuu Gantuya、Nugraha Arifin Budiman、Igarashi Ikuo
    • Journal Title

      PLOS ONE

      Volume: 18 Pages: e0284535

    • DOI

      10.1371/journal.pone.0284535

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Babesia gibsoni2022

    • Author(s)
      Liu Mingming、Igarashi Ikuo、Xuan Xuenan
    • Journal Title

      Trends in Parasitology

      Volume: 38 Pages: 815~816

    • DOI

      10.1016/j.pt.2022.03.001

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ascorbic acid co-administration with a low dose of diminazene aceturate inhibits the in vitro growth of Theileria equi, and the in vivo growth of Babesia microti2022

    • Author(s)
      Rizk Mohamed Abdo、El-Sayed Shimaa Abd El-Salam、Igarashi Ikuo
    • Journal Title

      Parasitology International

      Volume: 90 Pages: 102596~102596

    • DOI

      10.1016/j.parint.2022.102596

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of the in vitro and in vivo inhibitory effects of Artemisia herba-alba against the growth of piroplasm parasites2022

    • Author(s)
      Eltaysh Rasha、Rizk Mohamed、Sayed Shimaa、Abouelnasr Khaled、Abdallah Abdelnaser、Igarashi Ikuo
    • Journal Title

      Journal of Advanced Veterinary and Animal Research

      Volume: 9 Pages: 267~267

    • DOI

      10.5455/javar.2022.i592

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pomegranate (Punica granatum) Peel Inhibits the In Vitro and In Vivo Growth of Piroplasm Parasites2022

    • Author(s)
      Eltaysh Rasha、Rizk Mohamed Abdo、Elmishmishy Bassem、El-Sayed Shimaa Abd El-Salam、Abouelnasr Khaled、Igarashi Ikuo
    • Journal Title

      Journal of Parasitology Research

      Volume: 2022 Pages: 1~9

    • DOI

      10.1155/2022/8574541

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Repurposing of the Malaria Box for Babesia microti in mice identifies novel active scaffolds against piroplasmosis2022

    • Author(s)
      Rizk Mohamed Abdo、Baghdadi Hanadi B.、El-Sayed Shimaa Abd El-Salam、Eltaysh Rasha、Igarashi Ikuo
    • Journal Title

      Parasites & Vectors

      Volume: 15 Pages: 329

    • DOI

      10.1186/s13071-022-05430-4

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] <i>In vivo</i> activity and atom pair fingerprint analysis of MMV665941 against the apicomplexan parasite Babesia microti, the causative agent of babesiosis in humans and rodents2022

    • Author(s)
      Rizk Mohamed Abdo、El-Sayed Shimaa Abd El-Salam、Igarashi Ikuo
    • Journal Title

      Pathogens and Global Health

      Volume: 117 Pages: 315~321

    • DOI

      10.1080/20477724.2022.2128571

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In Vitro Inhibitory Effects and Bioinformatic Analysis of Norfloxacin and Ofloxacin on Piroplasm2022

    • Author(s)
      Rizk Mohamed Abdo、El-Sayed Shimaa Abd El-Salam、Igarashi Ikuo
    • Journal Title

      Acta Parasitologica

      Volume: 68 Pages: 213~222

    • DOI

      10.1007/s11686-022-00648-9

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The GP-45 Protein, a Highly Variable Antigen from Babesia bigemina, Contains Conserved B-Cell Epitopes in Geographically Distant Isolates2022

    • Author(s)
      Mercado-Uriostegui Miguel Angel、Castro-S?nchez Luis Alberto、Batiha Gaber El-Saber、Valdez-Espinoza Uriel Mauricio、Falc?n-Neri Alfonso、Ramos-Aragon Juan Alberto、Hern?ndez-Ortiz Ruben、Kawazu Shin-Ichiro、Igarashi Ikuo、Mosqueda Juan
    • Journal Title

      Pathogens

      Volume: 11 Pages: 591~591

    • DOI

      10.3390/pathogens11050591

    • Peer Reviewed / Open Access / Int'l Joint Research

URL: 

Published: 2023-12-25  

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