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2020 Fiscal Year Final Research Report

Elucidation of the molecular mechanism to maintain hierarchical structure of vascular system and and tumour angiogenesis

Research Project

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Project/Area Number 18H02363
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 42040:Laboratory animal science-related
Research InstitutionShiga University of Medical Science

Principal Investigator

Ema Masatsugu  滋賀医科大学, 動物生命科学研究センター, 教授 (60359578)

Co-Investigator(Kenkyū-buntansha) 水野 聖哉  筑波大学, 医学医療系, 准教授 (10633141)
杉山 文博  筑波大学, 医学医療系, 教授 (90226481)
Project Period (FY) 2018-04-01 – 2021-03-31
Keywords血管新生 / 血管内皮細胞 / マウス / 遺伝子改変
Outline of Final Research Achievements

We have identified Exoc3-like family genes which are specifically expressed in developing endothelial cells. To investigate the physiological roles of Exoc3L genes, we have created Exoc3L2-GFP knock-in mouse and found that GFP (Exoc3L2) is expressed in endothelial cells and KO embryos die in utero due to breeding. We also created Exoc3L4-GFP knock-in mouse and found GFP (Exoc3L4) is expressed in endothelial cells as well as cardiomyocytes. Exoc3L4 KO embryos die around E12.5, due to unknown mechanism.
We also created VEGFR3-Venus BAC Tg mouse useful for visualization of vascular and lymphatic endothelial cells.

Free Research Field

発生工学

Academic Significance and Societal Importance of the Research Achievements

Exoc3L遺伝子群の生理機能を体系的に明らかにし、その制御機構を解明することができれば、新たな腫瘍血管新生抑制療法の開発に繋がるものと期待される。

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Published: 2022-01-27  

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