2020 Fiscal Year Final Research Report
Analysis of retinal circuit development and function
| Project/Area Number |
18H02593
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 48010:Anatomy-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | 網膜 / 神経回路 |
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| Outline of Final Research Achievements |
We have studied molecular mechanisms underlying retinal photoreceptor development, synapse format ion, and retinal degeneration. In the current study, we identified candidate genes involved in retina circuit formation and analyzed their possible functions in the retina. We generated knockout and double-knockout mice and performed electrophysiological analysis and histological analysis. We carried out analyses on the Samd7 and Samd11 double knockout mice. We found that these molecules are essential for the regulation of light sensitivity and normal synaptic transmission from photoreceptor cells to bipolar cells. We reported these results as a research journal paper.
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| Free Research Field |
神経発生学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、中枢神経系における神経回路形成と機能発現のメカニズムの理解の進歩に貢献するとともに、網膜変性症を含む失明にいたる網膜疾患の視覚再生研究の基盤となると期待される。
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