Diagnosis and remedy for mitochondria-related nephropathy

2020 Fiscal Year Final Research Report

• Project/Area Number: 18H02822
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 53040:Nephrology-related
• Research Institution: Tohoku University
• Principal Investigator: Takaaki Abe 東北大学, 医工学研究科, 教授 (80292209)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: ミトコンドリア関連腎症 / MA-5 / GDF15 / PET

Outline of Final Research Achievements

Mitochondrial disease is one kind of intractable disease for which the diagnosis is still complicated by the distinct lack of sensitive and specific biomarkers and remedies.We reported that a new indole-derivative drug, MA-5, improved the cardiac and renal respiration and prolonged survival in diseas model mice carrying a deleted mitochondrial DNA mutation that makes it suitable for evaluating the phenotype of human mitochondrial diseases and renal diseases. In addition, mitochondrial disease is one kind of intractable disease for which the diagnosis is still complicated by the distinct lack of sensitive and specific biomarkers.
We found the potential biomarkers for mitochondrial dysfunction to improve diagnoses and develop new medicines to ameliorate the mitochondrial diseases.

Free Research Field

腎臓内科

Academic Significance and Societal Importance of the Research Achievements

本研究によりミトコンドリア機能異常の診断が容易となり、患を早期に予見してその抑制・予防に利用される社会が実現される。またミトコンドリアと疾患の関連が明らかになり、AKI、シスプラチン腎症だけ無くミトコンドリア関連腎症であるAKIや虚血性腎症に用いる治療法の開発に役に立つと考えられた。