Next generation therapy of podocytopathy developed by renal organoid

2020 Fiscal Year Final Research Report

• Project/Area Number: 18H02827
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 53040:Nephrology-related
• Research Institution: Tokai University
• Principal Investigator: MATSUSAKA Taiji 東海大学, 医学部, 教授 (50317749)
• Co-Investigator(Kenkyū-buntansha): 荒岡 利和 京都大学, iPS細胞研究所, 特定研究員 (40437661)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 腎臓病 / オルガノイド / ポドサイト

Outline of Final Research Achievements

Kidney cells change dramatically their character when they are cultured in dishes. Utilizing recently developed techniques, we generated kidney organoids from mouse kidney progenitor cells and established a method to induce injury and analyze the responses. We previously found that when a portion of kidney cells are injured, other cells are secondarily damaged in a mouse model. In the present study, we found this damage spreading is reproduced in kidney organoids.

Free Research Field

腎臓内科学

Academic Significance and Societal Importance of the Research Achievements

試験管内で腎臓病を再現可能になったので、薬剤の効果検証やスクリーニングが容易になり、腎臓病の治療法の開発に役立つと期待される。