Understanding of hematopoietic stem cell trafficking across developmental hematopoietic organs

2020 Fiscal Year Final Research Report

• Project/Area Number: 18H02843
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: Kumamoto University
• Principal Investigator: TAKIZAWA Hitoshi 熊本大学, 国際先端医学研究機構, 特別招聘教授 (10630866)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 造血幹細胞

Outline of Final Research Achievements

In hematopoietic system, one of somatic tissue, blood forming hematopoietic stem cells (HSCs) are born in aorta-gonad-mesonephros (AGM) region, and migrate to bone marrow (BM) through mutiple organs where adult hematopoiesis is maintained. This project focused on dynamics of HSC colonization in BM, identified HSC subset with different function, and calculated proliferation/differentiation/migration using mathematical model.

Free Research Field

血液学、幹細胞学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は成体末梢血中に常時遊走している造血幹細胞の生理学的機能、髄外造血の機序、骨髄移植後の骨髄再建能の効率化に向けて有用な知見をもたらすと期待される。