Fundamental studies for application of small linear accelerator to in-hospital BNCT

2022 Fiscal Year Final Research Report

• Project/Area Number: 18H02909
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: University of Tsukuba
• Principal Investigator: Matsumura Akira 筑波大学, 医学医療系, 客員教授 (90241819)
• Co-Investigator(Kenkyū-buntansha): 熊田 博明 筑波大学, 医学医療系, 准教授 (30354913) ; 中井 啓 筑波大学, 医学医療系, 准教授 (50436284) ; 鶴淵 隆夫 筑波大学, 医学医療系, 講師 (70778901)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: 小型加速器中性子線源 / 病院内BNCT / 基礎的・臨床的研究

Outline of Final Research Achievements

We conducted a series of fundamental experiments using a small neutron source based on a linear accelerator for in-hospital boron neutron capture therapy (BNСT). We have also developed a new patient positioning system that allows easy and correct orientation of the therapeutic target on the patient's head using real-time laser beams in combination with a treatment planning system called Tsukuba Plan. We have also accomplished preclinical studies using new promising boron compound candidates, alpha-d-mannopyranoside and eBNPs. These two stable compounds have shown proper tumoricidal effects.

Free Research Field

悪性脳腫瘍　放射線治療

Academic Significance and Societal Importance of the Research Achievements

悪性神経膠腫は未だ治癒に至らない難治性疾患である。本研究において、病院内併設用に開発された、小型中性子源を用いた中性子捕捉療法(Boron Neutron Capture Therapy)は今後の臨床応用にむけて非常に有望である。今後は、当院発のエビデンスを発信することで、悪性神経膠腫の治療発展および治療成績向上に貢献できることが多いに期待される。