Radiogenomics for uterine sarcoma

2020 Fiscal Year Final Research Report

• Project/Area Number: 18H02944
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: University of Fukui
• Principal Investigator: YOSHIDA Yoshio 福井大学, 学術研究院医学系部門, 教授 (60220688)
• Co-Investigator(Kenkyū-buntansha): 辻川 哲也 福井大学, 高エネルギー医学研究センター, 准教授 (30380033) ; 清野 泰 福井大学, 高エネルギー医学研究センター, 教授 (50305603) ; 岡沢 秀彦 福井大学, 高エネルギー医学研究センター, 教授 (50360813) ; 水谷 哲也 福井県立大学, 看護福祉学部, 教授 (90322734)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 婦人科腫瘍学 / 子宮肉腫 / 肺転移 / Radiogenomics

Outline of Final Research Achievements

We found that GDF15, Progranulin, and Osteopontin are secreted proteins that are specifically highly expressed in early-stage uterine sarcoma. The regulatory genes of these secreted proteins were also found to be the genes that control exosome secretion. These findings suggest that exosomes are secreted from the primary tumor from an early stage in uterine sarcoma, and that exosomes play a major role in the acquisition of a protective environment in uterine sarcoma through active communication between primary tumor and metastatic tumor cells.In vivo uterine sarcoma "Radiomics" analysis showed that the higher-order textural features of Complementarity and Strength were specific to metastases.These findings suggest that the expression of Complementarity and Strength higher-order texture features in metastases may be a biomarker for the therapeutic effect of anti-esosome administration in uterine sarcoma.

Free Research Field

婦人科腫瘍

Academic Significance and Societal Importance of the Research Achievements

難治性、子宮肉腫症例に対する新たなバイオマーカーの樹立と子宮肉腫における抗exosome抗体投与における治療効果の可能性が示唆された