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2020 Fiscal Year Annual Research Report

Advanced research of vitreology

Research Project

Project/Area Number 18H02957
Research InstitutionKagoshima University

Principal Investigator

坂本 泰二  鹿児島大学, 医歯学域医学系, 教授 (10235179)

Co-Investigator(Kenkyū-buntansha) 原 博満  鹿児島大学, 医歯学域医学系, 教授 (20392079)
渡邊 睦  鹿児島大学, 理工学域工学系, 教授 (50325768)
橋口 照人  鹿児島大学, 医歯学域医学系, 教授 (70250917)
Project Period (FY) 2018-04-01 – 2021-03-31
Keywords画像解析 / 人工知能 / 脈絡膜血管 / 糖尿病網膜症 / 光干渉断層計
Outline of Annual Research Achievements

本年度は、画像解析に大きな進歩を得た。従来、網膜の血管の形状はフルオレセイン蛍光眼底造影がゴールドスタンダードであった。しかし、アナフィラキシーショックなどの副反応の危険性が大きかった。一方、近年開発されたoptical coherence tomography angiography (OCT-A)は副反応なしに血管の造影が可能であるが、糖尿病網膜症や血管閉塞症の重要なサインである毛細血管瘤が見いだせないという問題があった。そこで我々は多色のレーザーを用いたmulti laser scan(MC-SLO)の可能性を探った。その結果、MC-SLOを使った場合、フルオレセイン蛍光眼底造影とほぼ同等の毛細血管瘤を発見できただけではなく、色素漏出の強いタイプを選択的に発見できるという機能的評価も可能であった。これは臨床眼科学に大きな貢献をするものとして、invited reviewに取り上げられた。(Terasaki H,Sonoda S,Tomita M,Sakamoto T〈https://pubmed.ncbi.nlm.nih.gov/33670287/〉Recent Advances and Clinical Application of Color Scanning Laser Ophthalmoscope. .J Clin Med.2021)
また、周辺部血管の描出にも新しい発見を行った。最近開発された、超広角眼底撮影装置では200度以上の広角眼底撮影が可能である。そこでそれとOCTを組み合わせる研究が進んでいる。しかし、周辺眼底は、ゆがみが大きく正確な評価が困難であった。そこで、reverse three dimensional projection methodを用いて、vortex veinの位置を新たに特定した。その結果を報告した所、企業製品に実装する検討がなされている。(Funatsu R, Sakamoto T. et al. Quantitative evaluations of vortex vein ampullae by adjusted 3D reverse projection model of ultra-widefield fundus images. Sci Rep 2021)。その他、新たな人工知能利用による脈絡膜血管の解析なども論文化された。

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

  • Research Products

    (32 results)

All 2021 2020

All Journal Article (19 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 19 results,  Open Access: 19 results) Presentation (13 results) (of which Invited: 2 results)

  • [Journal Article] Recent Advances and Clinical Application of Color Scanning Laser Ophthalmoscope2021

    • Author(s)
      Terasaki Hiroto、Sonoda Shozo、Tomita Masatoshi、Sakamoto Taiji
    • Journal Title

      Journal of Clinical Medicine

      Volume: 10 Pages: 718~718

    • DOI

      10.3390/jcm10040718

    • Peer Reviewed / Open Access
  • [Journal Article] Macular irregularities of optical coherence tomographic vertical cross sectional images in school age children2021

    • Author(s)
      Yamashita Takehiro、Terasaki Hiroto、Asaoka Ryo、Yoshihara Naoya、Kakiuchi Naoko、Sakamoto Taiji
    • Journal Title

      Scientific Reports

      Volume: 11 Pages: -

    • DOI

      10.1038/s41598-021-84808-3

    • Peer Reviewed / Open Access
  • [Journal Article] Changes in Choroidal Component Ratio and Circulation After Coffee Intake in Healthy Subjects2021

    • Author(s)
      Nagasato Daisuke、Mitamura Yoshinori、Egawa Mariko、Murao Fumiko、Nagasawa Toshihiko、Komori Natsumi、Sonoda Shozo、Sakamoto Taiji、Tabuchi Hitoshi
    • Journal Title

      Investigative Opthalmology & Visual Science

      Volume: 62 Pages: 27~27

    • DOI

      10.1167/iovs.62.3.27

    • Peer Reviewed / Open Access
  • [Journal Article] Quantification of vessels of Haller’s layer based on en-face OCT images2021

    • Author(s)
      Shiihara Hideki、Sonoda Shozo、Terasaki Hiroto、Kakiuchi Naoko、Shinohara Yuki、Tomita Masatoshi、Sakamoto Taiji
    • Journal Title

      Retina

      Volume: - Pages: -

    • DOI

      10.1097/IAE.0000000000003166

    • Peer Reviewed / Open Access
  • [Journal Article] Clinical characteristics and visual outcomes of work-related open globe injuries in Japanese patients2020

    • Author(s)
      Morikawa Shohei、Japan-Clinical Research of Study (J-CREST) group、Okamoto Fumiki、Okamoto Yoshifumi、Mitamura Yoshinori、Ishikawa Hiroto、Harimoto Kozo、Ueda Tetsuo、Sakamoto Taiji、Sugitani Kazuhiko、Sawada Osamu、Mori Junya、Takamura Yoshihiro、Oshika Tetsuro
    • Journal Title

      Scientific Reports

      Volume: 10 Pages: -

    • DOI

      10.1038/s41598-020-57568-9

    • Peer Reviewed / Open Access
  • [Journal Article] Real-world effectiveness and safety of ranibizumab for the treatment of myopic choroidal neovascularization: Results from the LUMINOUS study2020

    • Author(s)
      Hamilton Robin D.、Clemens Andreas、Minnella Angelo Maria、Lai Timothy Y. Y.、Dai Hong、Sakamoto Taiji、Gemmy Cheung Chui Ming、Ngah Nor Fariza、Dunger-Baldauf Cornelia、Holz Frank G.、on behalf of all the LUMINOUS study investigators
    • Journal Title

      PLOS ONE

      Volume: 15 Pages: -

    • DOI

      10.1371/journal.pone.0227557

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Factors in Color Fundus Photographs That Can Be Used by Humans to Determine Sex of Individuals2020

    • Author(s)
      Yamashita Takehiro、Asaoka Ryo、Terasaki Hiroto、Murata Hiroshi、Tanaka Minoru、Nakao Kumiko、Sakamoto Taiji
    • Journal Title

      Translational Vision Science & Technology

      Volume: 9 Pages: 4~4

    • DOI

      10.1167/tvst.9.2.4

    • Peer Reviewed / Open Access
  • [Journal Article] Numerous retinal pigment epithelial elevations and drusen associated with unusual dilated choroidal vessels seen at choriocapillaris level in macular area2020

    • Author(s)
      Okubo Akiko、Unoki Kazuhiko、Sameshima Munefumi、Sakamoto Taiji
    • Journal Title

      American Journal of Ophthalmology Case Reports

      Volume: 18 Pages: 100634~100634

    • DOI

      10.1016/j.ajoc.2020.100634

    • Peer Reviewed / Open Access
  • [Journal Article] Relationship Between Funduscopic Conus and Optic Disc Factors Associated with Myopia in Young Healthy Eyes2020

    • Author(s)
      Terasaki Hiroto、Yamashita Takehiro、Tanaka Minoru、Nakao Kumiko、Sakamoto Taiji
    • Journal Title

      Investigative Opthalmology & Visual Science

      Volume: 61 Pages: 40~40

    • DOI

      10.1167/iovs.61.2.40

    • Peer Reviewed / Open Access
  • [Journal Article] Alteration of choroidal vascular structure in diabetic macular edema2020

    • Author(s)
      Kase Satoru、Endo Hiroaki、Takahashi Mitsuo、Ito Yuki、Saito Michiyuki、Yokoi Masahiko、Katsuta Satoshi、Sonoda Shozo、Sakamoto Taiji、Ishida Susumu、Kase Manabu
    • Journal Title

      Graefe's Archive for Clinical and Experimental Ophthalmology

      Volume: 258 Pages: 971~977

    • DOI

      10.1007/s00417-020-04604-z

    • Peer Reviewed / Open Access
  • [Journal Article] Real-world outcomes with ranibizumab in branch retinal vein occlusion: The prospective, global, LUMINOUS study2020

    • Author(s)
      Pearce Ian、Clemens Andreas、Brent Michael H.、Lu Lin、Gallego-Pinazo Roberto、Minnella Angelo Maria、Creuzot-Garcher Catherine、Spital Georg、Sakamoto Taiji、Dunger-Baldauf Cornelia、McAllister Ian L.、on behalf of all the LUMINOUS study investigators
    • Journal Title

      PLOS ONE

      Volume: 15 Pages: -

    • DOI

      10.1371/journal.pone.0234739

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quantitative analyses of diameter and running pattern of choroidal vessels in central serous chorioretinopathy by en face images2020

    • Author(s)
      Shiihara Hideki、Sonoda Shozo、Terasaki Hiroto、Kakiuchi Naoko、Yamashita Takehiro、Uchino Eisuke、Murao Fumiko、Sano Hiroki、Mitamura Yoshinori、Sakamoto Taiji
    • Journal Title

      Scientific Reports

      Volume: 10 Pages: -

    • DOI

      10.1038/s41598-020-66858-1

    • Peer Reviewed / Open Access
  • [Journal Article] Changes in choroidal structure following intravitreal aflibercept therapy for retinal vein occlusion2020

    • Author(s)
      Mitamura Yoshinori、Enkhmaa Tserennadmid、Sano Hiroki、Niki Masanori、Murao Fumiko、Egawa Mariko、Sonoda Shozo、Sakamoto Taiji
    • Journal Title

      British Journal of Ophthalmology

      Volume: - Pages: -

    • DOI

      10.1136/bjophthalmol-2020-316214

    • Peer Reviewed / Open Access
  • [Journal Article] Anti-vascular endothelial growth factor in neovascular age-related macular degeneration a systematic review of the impact of anti-VEGF on patient outcomes and healthcare systems2020

    • Author(s)
      Finger Robert P.、Daien Vincent、Eldem Bora M.、Talks James S.、Korobelnik Jean-Francois、Mitchell Paul、Sakamoto Taiji、Wong Tien Yin、Pantiri Krystallia、Carrasco Joao
    • Journal Title

      BMC Ophthalmology

      Volume: 20 Pages: -

    • DOI

      10.1186/s12886-020-01554-2

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MORE EFFECTIVE SCREENING FOR EPIRETINAL MEMBRANES WITH MULTICOLOR SCANNING LASER OPHTHALMOSCOPE THAN WITH COLOR FUNDUS PHOTOGRAPHS2020

    • Author(s)
      Terasaki Hiroto、Sonoda Shozo、Shiihara Hideki、Kakiuchi Naoko、Funatsu Ryoh、Shirasawa Makoto、Sakamoto Taiji
    • Journal Title

      Retina

      Volume: 40 Pages: 1412~1418

    • DOI

      10.1097/IAE.0000000000002595

    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between peripapillary choroidal thickness and degree of tessellation in young healthy eyes2020

    • Author(s)
      Yamashita Takehiro、Terasaki Hiroto、Tanaka Minoru、Nakao Kumiko、Sakamoto Taiji
    • Journal Title

      Graefe's Archive for Clinical and Experimental Ophthalmology

      Volume: 258 Pages: 1779~1785

    • DOI

      10.1007/s00417-020-04644-5

    • Peer Reviewed / Open Access
  • [Journal Article] Association of foveal avascular zone with the metamorphopsia in epiretinal membrane2020

    • Author(s)
      Shiihara Hideki、Terasaki Hiroto、Sonoda Shozo、Kakiuchi Naoko、Yamaji Hidetaka、Yamaoka Shinnosuke、Uno Toshihiko、Watanabe Mutsumi、Sakamoto Taiji
    • Journal Title

      Scientific Reports

      Volume: 10 Pages: -

    • DOI

      10.1038/s41598-020-74190-x

    • Peer Reviewed / Open Access
  • [Journal Article] Evolution of treatment paradigms in neovascular age-related macular degeneration: a review of real-world evidence2020

    • Author(s)
      Daien Vincent、Finger Robert P、Talks James S、Mitchell Paul、Wong Tien Y、Sakamoto Taiji、Eldem Bora M、Korobelnik Jean-Franois
    • Journal Title

      British Journal of Ophthalmology

      Volume: - Pages: -

    • DOI

      10.1136/bjophthalmol-2020-317434

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Concerns about the interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication2020

    • Author(s)
      Vavvas Demetrios G.、Sarraf David、Sadda SriniVas R.、Eliott Dean、Ehlers Justis P.、Waheed Nadia K.、Morizane Yuki、Sakamoto Taiji、Tsilimbaris Miltiadis、Miller John B.
    • Journal Title

      Eye

      Volume: 34 Pages: 2153~2154

    • DOI

      10.1038/s41433-020-1084-9

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Treatment of diabetic macular edema in real-world clinical practice: the effect of aging.2020

    • Author(s)
      Sentaro Kusuhara, Masahiko Shimura, Shigehiko Kitano, Taiji Sakamoto
    • Organizer
      第59回日本網膜硝子体学会総会
    • Invited
  • [Presentation] Visual prognosis of submacular hemorrhage secondary to age-related macular degeneration: a retrospective multicenter survey.2020

    • Author(s)
      Aki Kato, Takashi Araki, Takeshi Kimura, Takamasa Kinoshita, Fumiki Okamoto, Yoshinori Mitamura, Taiji Sakamoto, Akiko Miki, Yoshihiro Takamura, Hisashi Matsubara, Hiroki Tsujinaka, Yuichiro Ogura, Tsutomu Yasukawa
    • Organizer
      第59回日本網膜硝子体学会総会
    • Invited
  • [Presentation] 深層学習によるOCTの層境界検出モデルの出力の不確かさ(Uncertainty)の定量化2020

    • Author(s)
      椎原秀樹,園田祥三,寺﨑寛人,船津諒,柴涼介,熊谷佳紀,本多直人,坂本泰二
    • Organizer
      第124回日本眼科学会総会
  • [Presentation] 小学生の眼底写真パラメーターによる性別判定2020

    • Author(s)
      山下高明,山上理央,芳原直也,柿内奈保子,坂本泰二
    • Organizer
      第124回日本眼科学会総会
  • [Presentation] 超広角眼底撮影のモンタージュ画像を用いた渦静脈・視神経乳頭・黄斑の位置関係2020

    • Author(s)
      船津諒,園田祥三,寺﨑寛人,柿内奈保子,椎原秀樹,篠原祐樹,富田将利,廣川真梨子,田邉泰士,石田誠,坂本泰二
    • Organizer
      第124回日本眼科学会総会
  • [Presentation] 中学生の眼底写真パラメーターによる性別判定2020

    • Author(s)
      山下高明,山上理央,芳原直也,柿内奈保子,坂本泰二
    • Organizer
      第9回日本視野画像学会学術集会
  • [Presentation] 思春期前児童の眼底写真を用いた性別判定2020

    • Author(s)
      山下高明,山上理央,芳原直也,柿内奈保子,坂本泰二
    • Organizer
      第31回日本成長学会
  • [Presentation] 久米島スタディ健常眼の眼底写真パラメーターによる性別判定2020

    • Author(s)
      山下高明,朝岡亮,岩瀬愛子,坂本泰二,酒井寛,新家眞
    • Organizer
      第31回日本緑内障学会
  • [Presentation] 中学生における乳頭周囲紋理程度と眼球形状パラメータとの関係2020

    • Author(s)
      山下高明,芳原直也,柿内奈保子,坂本泰二
    • Organizer
      第74回日本臨床眼科学会
  • [Presentation] 超広角眼底撮影のモンタージュ画像を用いた黄斑灌流に関わる渦静脈の解析2020

    • Author(s)
      船津諒,園田祥三,寺﨑寛人,柿内奈保子,篠原祐樹,富田将利,豊留貴久子,廣川真梨子,田邉泰士,石田誠,坂本泰二
    • Organizer
      第74回日本臨床眼科学会
  • [Presentation] 65歳以上の高齢者正常眼の後極部眼球形状2020

    • Author(s)
      寺﨑寛人,山下高明,船津諒,吉永就正,鮫島誠治,白澤誠,山下敏史,坂本泰二
    • Organizer
      第74回日本臨床眼科学会
  • [Presentation] 深層学習によるOCTの層境界検出モデルの出力の不確かさの定量化による網膜異常検知2020

    • Author(s)
      椎原秀樹,園田祥三,寺﨑寛人,船津諒,柴涼介,熊谷佳紀,本田直人,坂本泰二
    • Organizer
      第1回日本眼科AI学会総会
  • [Presentation] 共焦点レーザー走査型検眼鏡とOCTAの糖尿病網膜症の毛細血管瘤の検出率の比較2020

    • Author(s)
      迫野能士,寺﨑寛人,船津諒,椎原秀樹,園田祥三,坂本泰二
    • Organizer
      第35回日本糖尿病合併症学会・第26回日本糖尿病眼学会

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Published: 2021-12-27  

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