2020 Fiscal Year Final Research Report
Development of fertilization therapy for functional recovery of stem cells-wasting pathology
| Project/Area Number |
18H02963
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 56070:Plastic and reconstructive surgery-related
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | 放射線障害 / 幹細胞 |
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| Outline of Final Research Achievements |
In vitro study using cultured human ASCs found that a single dose of irradiation resulted in a dose-dependent cytotoxicity, but only up to a 2-Gy dose, suggesting the cell cycle stage is critical for determination of susceptibility of stem cells to radiation. The animal study revealed that, in contrast to acute radiation injury, chronic radiation damage-associated wound healing capacity was not proportional to the individual dose or the total irradiation dose received, but appeared to be highly influenced by the number of and the interval between irradiations, if each dose was more than 2 Gy. After radiation exposure, the tissue functions, including vascularity and wound healing capacity, were impaired progressively over time. This result indicated that the tissue devitalization did not result directly from the acute injury; it resulted from the stem cell depletion that was a progressive consequence from repeated irradiation.
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| Free Research Field |
形成外科
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| Academic Significance and Societal Importance of the Research Achievements |
本研究結果により、放射線障害の本質は幹細胞死であり、幹細胞枯渇による組織の機能低下であることがわかった。その障害は進行性に増悪するものであり、放射線障害を改善するための、照射プロトコールの開発や予防法の開発に大きく貢献できるものである。
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