2020 Fiscal Year Final Research Report
Elucidation of effects of cariogenic bacteria on organ-linked network due to oral barrier breakdown
| Project/Area Number |
18H03010
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 57070:Developmental dentistry-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
野村 良太 大阪大学, 歯学研究科, 准教授 (90437385)
大川 玲奈 大阪大学, 歯学部附属病院, 講師 (80437384)
大継 將寿 大阪大学, 歯学研究科, 助教 (40803086)
鋸屋 侑布子 大阪大学, 歯学研究科, 助教 (40803078)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | Streptococcus mutans / コラーゲン結合タンパク / 感染性心内膜炎 / 脳出血 / 脳内微小出血 / IgA腎症 / 重度う蝕 / Citrus unshiu |
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| Outline of Final Research Achievements |
We evaluated the pathogenicity of 120-kDa collagen-binding proteins (CBP) of Streptococcus mutans for systemic disease development. CBP-positive S. mutans organisms in the oral cavity were found to be involved in development of cardiovascular diseases, including infective endocarditis and cerebral microbleeds, as well as IgA nephropathy, classified as a designated intractable disease. As a novel approach for inhibition of S. mutans, fruit-derived components exhibited inhibitory effects on both bacterial growth and biofilm formation activities.
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| Free Research Field |
歯学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究結果から、口腔内に存在するCBP 陽性のS. mutansがう蝕だけでなく様々な全身疾患の増悪化に関わることが明らかになり、口腔衛生状態を良好に保ちう蝕の予防に努めることが、全身疾患の予防にも有効である可能性を示すことができた。また、ある種の食品を応用することにより、S. mutansによるう蝕や全身疾患を低減できる可能性を示すことができた。
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