The mechanism of motoric cognitive risk and dementia

2020 Fiscal Year Final Research Report

• Project/Area Number: 18H03185
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: Doi Takehiko 国立研究開発法人国立長寿医療研究センター, 老年学・社会科学研究センター, 室長 (60589026)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 歩行 / 認知機能 / 高齢者

Outline of Final Research Achievements

To investigate the mechanism of motoric cognitive risk syndrome as a risk factor for dementia, we investigated a multifaceted approach using biomarkers and brain imaging indices.　The results showed that motoric cognitive risk syndrome was associated with brain imaging indices, as well as biomarkers attributed to them, for a higher risk of dementia.

Free Research Field

老年学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果より、motoric cognitive risk syndromeが血管性病変やアルツハイマー病理に関連する可能性が示唆された。そのため、それらの病理変化に対し検討されてきた介入方法の中から、どのような方法が適切かを精査し、motoric cognitive risk syndromeに対する介入を検討する必要があると考えられる。