The role of the DMH in age-associated disturbance of sleep and body temperature

2021 Fiscal Year Final Research Report

• Project/Area Number: 18H03186
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: Satoh Akiko 国立研究開発法人国立長寿医療研究センター, ジェロサイエンス研究センター, 副部長 (80800979)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: 老化 / 視床下部 / 体温

Outline of Final Research Achievements

In this study, we addressed whether reduction of Prdm13 function in the dorsomedial hypothalamus causes a deficit in thermoregulation before sleep onset, resulting in sleep problems. Mouse studies using old mice, dietary restricted mice, and dorsomedial hypothalamic-specific Prdm13-knockout mice revealed that changes in body temperature at the onset of sleep is highly correlated with changes in sleep regulatory network. We also observed there is a sexual dimorphism in this regulation.

Free Research Field

老化生物学

Academic Significance and Societal Importance of the Research Achievements

睡眠と体温の調節には密接な関係があるが、老化過程におけるこれらの機能変化とそのメカニズムは不明である。本研究から老化寿命を制御しうる新規視床下部神経が睡眠調節に伴う体温調節に関与することが明らかにされ,、体温調節と老化制御をつなぐ鍵となる制御系が見出された。