2021 Fiscal Year Final Research Report
Kidney-mediated aging process
| Project/Area Number |
18H03191
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Keywords | 生体適応能力 / 生体防御反応 / 老化 / 腎臓病 / 異化反応 |
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| Outline of Final Research Achievements |
The purpose of this study was to elucidate the pathophysiology of the deterioration of renal function, which directly affects the metabolism of organs and causes individual aging. The study revealed that in 5/6 nephrectomized rats with chronic kidney disease, which causes polyuria due to reduced renal concentrating ability, or in rats with liver failure due to administration of diethylnitrosamine, reabsorption of water by the kidneys is necessary to maintain body fluid, and that urea is produced and accumulated in the kidneys through catabolism, and that the The metabolic derangement caused by the breakdown of urea production and accumulation in the kidneys leads to hypertension via functional changes in the skin.
If we can clarify the whole picture of this mechanism and develop a method to control it in the future, it is assumed that it will be possible to control physical condition in humans.
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| Free Research Field |
薬理学
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| Academic Significance and Societal Importance of the Research Achievements |
生体は環境の変化やストレスに適応する能力を持つが、徐々にその力は減衰し、老いとともに様々な病気が発症する。しかし、これまでの研究すべてが機能低下の「原因・要因」に着目するものばかりであり、個体の機能低下を防ぐための生体の「環境適応能力（防御反応）」に着目したものが皆無であったことが、根本的な解決が見つからない最大の問題であると考えられる。本基盤研究をきっかけとし、「夏眠様反応」という生体防御機構の全容が解明されれば、全く新しい学術領域の創出となり、QOL の向上や健康増進プロモーション、ならびに疾患横断的な治療法開発のブレイクスルーにつながるものであると考える。
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