Analysis of reproductive toxicity and nonlinear reaction mechanism of bisphenol A analogues in food containers

2021 Fiscal Year Final Research Report

• Project/Area Number: 18H03381
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 63030:Chemical substance influence on environment-related
• Research Institution: Gifu Pharmaceutical University
• Principal Investigator: Nakanishi Tsuyoshi 岐阜薬科大学, 薬学部, 教授 (50303988)
• Co-Investigator(Kenkyū-buntansha): 永瀬 久光 岐阜薬科大学, 薬学部, 名誉教授 (40141395) ; 木村 朋紀 摂南大学, 理工学部, 准教授 (70340859) ; 井戸 章子 岐阜薬科大学, 薬学部, 助教 (00336629)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: フルオレン9-ビスフェノール / エストロゲン作動性 / 内分泌かく乱

Outline of Final Research Achievements

In our current study, we conducted a risk assessment of fluorene 9-bisphenol (BHPF), an alternative bisphenol A for which no risk assessment has yet been done. We evaluated the toxicity of BHPF using guideline-based toxicity test and also examined the details of its endocrine disrupting effects using estrogen-responsive reporter mice, which we have established. As a result, we were able to identify a non-observed adverse effect level of BHPF as well as a dose range in which it can be safely used. BHPF was also detected in human blood, although not at high levels, suggesting that humans are also exposed to a certain amount of BHPF.

Free Research Field

毒性学

Academic Significance and Societal Importance of the Research Achievements

BHPFは、飲料水用のペットボトル等に使用されているにもかかわらず、これまでその毒性に関する情報が全く存在しなかった。本研究では無毒性量を同定することで、その安全使用に関する用量域を示すことができたことから、学術的意義はもちろんのこと社会的意義も非常に大きい成果であると言える。