2022 Fiscal Year Final Research Report
Novel approach for spectroscopic molecule detection: Pioneering multicolor multiphoton photothermal spectroscopy
Project/Area Number |
18H03915
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Medium-sized Section 34:Inorganic/coordination chemistry, analytical chemistry, and related fields
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Research Institution | Kyushu University |
Principal Investigator |
Harata Akira 九州大学, 総合理工学研究院, 教授 (90222231)
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Project Period (FY) |
2018-04-01 – 2023-03-31
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Keywords | 2色2光子励起 / 光熱変換 / 非蛍光性化学種 / 超高感度検出 / 紫外レーザー分光 / 多色多光子吸収 / ヘテロダイン検出 / 偏光依存性 |
Outline of Final Research Achievements |
Many important and trace amounts of biological and environmental species in liquid solutions are non-fluorescent and absorb light only in the ultraviolet region. A general-purpose method that can detect them without chemical modification and with high sensitivity is required. A label-free and ultra-sensitive detection technique for non-fluorescent chemical species that involves versatility, high sensitivity, and species selectivity is designed and examined by further improving a deep-UV photoexcitation photothermal heterodyne-interferometer. It has been demonstrated that deep UV absorption bands are photoexcited by two-color two-photon excitation using an all-solid-state laser as an excitation light source, and that thermal lens spectra and photoacoustic spectra are successfully measured. Performance of a separation-detection system with high-performance liquid-chromatography and the photothermal heterodyne-interferometer is reported.
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Free Research Field |
分析化学
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Academic Significance and Societal Importance of the Research Achievements |
新しい計測技術が、科学技術の発展の礎となる例、また、安全・安心な社会を実現する上での実用的重要性を示す例には事欠かない。蛍光性化学種の高感度検出がもたらした技術革新は顕著である。一方、化学修飾に適さない非蛍光性化学種には敢えて触れないことも一部習慣化されており、科学技術の課題でもある。本研究は、重要性が高く微量な生体・環境関連の溶液中化学種の無修飾・高感度検出において、次の2つの点を実証したことに重要な意義がある。2色2光子励起により深紫外吸収帯を励起できること。光熱変換検出により無蛍光性化学種が高感度分離・検出できること。これらは、非蛍光性化学種の汎用的な高感度検出実現に貢献するものである。
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