2020 Fiscal Year Final Research Report
Molecular mechanisms of cancer cell survival and maintenance
| Project/Area Number |
18H04032
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Medium-sized Section 50:Oncology and related fields
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | がん微小環境 / 腫瘍免疫 / マクロファージ / 樹状細胞 / SIRPα |
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| Outline of Final Research Achievements |
Tumor cells create a favorable environment for their own survival and maintenance by controlling the "tumor microenvironment" that consists of surrounding immune cells. The CD47-SIRPα signaling pathway has been considered as a key molecular signal in the regulation of the tumor microenvironment, which protects cancer cells from innate immune cells such as dendritic cells and macrophages. In the present study, we clarified new regulatory mechanisms of tumor immuity by innate immune cells, which is regulated by the CD47-SIRPα system and other SIRP faminily molecules.
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| Free Research Field |
基礎医学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究によって、研究代表者が見出している「がん細胞が細胞間シグナルCD47-SIRPα系を利用して貪食細胞からの排除を逃れる機構」による、これまで未解明であったがん細胞による「自然系細胞を介したがん排除」を回避する分子機構を解明する意味で学術的意義を有すると共に、新規がん治療法の創出に資する社会的意義の高い研究成果を得られた。
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