Biocompatible devices with soft wet electrodes

2022 Fiscal Year Final Research Report

• Project/Area Number: 18H04158
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 90:Biomedical engineering and related fields
• Research Institution: Tohoku University
• Principal Investigator: Nishizawa Matsuhiko 東北大学, 工学研究科, 教授 (20273592)
• Co-Investigator(Kenkyū-buntansha): 田中 徹 東北大学, 医工学研究科, 教授 (40417382)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: ハイドロゲル / 酵素電池 / 経皮通電 / 生体親和性

Outline of Final Research Achievements

The soft-wet electrodes (enzyme-modified fabric electrode and hydrogel electrode) were developed and utilized to create platforms of medical devices for minimally invasive self-medication (self-medication) and electrical measurement and stimulation (diagnosis and treatment). The developed bio-power patch had flexibility applicable for skin, and exhibited drug penetration enhancement and analgesic effects through enzyme-induced redox reaction. The effectiveness of the hydrogel-based organic electrodes as intracranial electrodes in sheet form and vagus nerve electrodes in cuff form was demonstrated in animal experiments.

Free Research Field

生体イオントロニクス

Academic Significance and Societal Importance of the Research Achievements

本研究で開発したソフトウェット電極デバイスは、生体組織と同等の柔軟性を有し、低侵襲の服薬・診断・治療に有効である。このような生体親和性に優れるウェアラブルおよび埋込型の電極デバイスは、AI/IoTを基盤とする高効率なネットワーク化IT医療システムの端末として必須であり、超高齢化社会化が抱える医療費・医療アクセス・介護などの深刻な問題への対応に貢献すると期待できる。