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Products Report

乱流依存性血小板産生機構の分子基盤の解明と生体外製造システムへの応用

Research Project

Project/Area Number 18H04164
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionKyoto University

Principal Investigator

ETO KOJI  京都大学, iPS細胞研究所, 教授 (50286986)

Co-Investigator(Kenkyū-buntansha) 中村 壮  京都大学, iPS細胞研究所, 特定拠点助教 (50769833)
Project Period (FY) 2018-04-01 – 2021-03-31
  • Research Products

    (57 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (25 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 22 results,  Open Access: 15 results) Presentation (26 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 2 results)

  • [Int'l Joint Research] ノースカロライナ大学チャペルヒル校医学部/ボストン小児病院・ハーバード大学医学部(米国)

    • Country Name
      U.S.A.
    • Counterpart Institution
      ノースカロライナ大学チャペルヒル校医学部/ボストン小児病院・ハーバード大学医学部
  • [Int'l Joint Research] パビア大学医学部(イタリア)

    • Country Name
      ITALY
    • Counterpart Institution
      パビア大学医学部
  • [Journal Article] Development of platelet replacement therapy using human induced pluripotent stem cells2021

    • Author(s)
      Nakamura S, Sugimoto N, Eto K
    • Journal Title

      Dev Growth Differ

      Volume: 63(2) Pages: 178-186

    • DOI

      10.1111/dgd.12711

    • Peer Reviewed / Open Access
  • [Journal Article] Extracellular laminin regulates hematopoietic potential of pluripotent stem cells through integrin beta1-ILK-beta catenin-JUN axis axis2021

    • Author(s)
      Yuzuhira A, Nakamura S, Sugimoto N, Kihara S, Nakagawa M, Yamamoto T, Sekiguchi K, Eto K
    • Journal Title

      Stem Cell Research

      Volume: 53 Pages: -

    • DOI

      10.1016/j.scr.2021.102287

    • Peer Reviewed / Open Access
  • [Journal Article] Generation and manipulation of human iPSC-derived platelets2021

    • Author(s)
      Sugimoto N, Eto K
    • Journal Title

      Cell Mol Life Sci

      Volume: 78(7) Pages: 3385-3401

    • DOI

      10.1007/s00018-020-03749-8

    • Peer Reviewed / Open Access
  • [Journal Article] Combined transcriptome and proteome profiling of SRC kinase activity in healthy and E527K defective megakaryocytes2021

    • Author(s)
      De Kock L, Ver Donck F, Thys C, Wijgaerts A, Eto K, Van Geet C, Freson K
    • Journal Title

      Haematologica

      Volume: 106(12) Pages: 3206-3210

    • DOI

      10.3324/haematol.2021.279248

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome2021

    • Author(s)
      Kato H, Maezawa Y, Ouchi Y, Takayama N, Sone M, Sone K, Takada-Watanabe A, Tsujimura K, Koshizaka M, Nagasawa S, Saitoh H, Ohtaka M, Nakanishi M, Tahara H, Shimamoto A, Iwama A, Eto K, Yokote K
    • Journal Title

      Stem Cell Research

      Volume: 53 Pages: 102360

    • DOI

      10.1016/j.scr.2021.102360

    • Peer Reviewed / Open Access
  • [Journal Article] Three - dimensional microchannel reflecting cell size distribution for on - chip production of platelet - like particles2021

    • Author(s)
      Y Sakuma S, Kumon H, Nakamura S, Kasai Y, Eto K, Arai F
    • Journal Title

      Microfluidics and Nanofluidics

      Volume: 25 Pages: 36

    • DOI

      10.1007/s10404-021-02433-y

    • Peer Reviewed / Open Access
  • [Journal Article] Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome2021

    • Author(s)
      Kato H, Maezawa Y, Takayama N, Ouchi Y, Kaneko H, Kinoshita D, Takada-Watanabe A, Oshima M, Koshizaka M, Ogata H, Kubota Y, Mitsukawa N, Eto K, Iwama A, Yokote K
    • Journal Title

      Aging(Albany NY)

      Volume: 13 Issue: 4 Pages: 4946-4961

    • DOI

      10.18632/aging.202696

    • Peer Reviewed / Open Access
  • [Journal Article] The effect of megakaryocytes and platelets derived from human induced pluripotent stem cells on bone formation2021

    • Author(s)
      Sato M, Shiga Y, Takayama N, Sone M, Kosaka K, Motegi I, Mizuki N, Inage K, Eguchi Y, Narita M, Orita S, Eto K, Ohtori S
    • Journal Title

      Supine Surgery and Related Research

      Volume: 5 Issue: 3 Pages: 186-204

    • DOI

      10.22603/ssrr.2020-0226.eCollection2021

    • Peer Reviewed
  • [Journal Article] The Cxxxcl subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation2021

    • Author(s)
      Kikuchi M, Onodera A, Kokubo K, Ichikawa T, Moromoto Y, Kawakami E, Takayama N, Eto K, Koseki H, Hirahara K, Nakayama T
    • Journal Title

      Journal of Experimental Medicine

      Volume: 218 Issue: 4 Pages: e20201690

    • DOI

      10.22603/ssrr.2020-0226.eCollection2021

    • Peer Reviewed
  • [Journal Article] iPS細胞技術を応用した血液疾患およびがんに対する治療戦略2021

    • Author(s)
      杉本直志、江藤浩之
    • Journal Title

      先進医療Navigator

      Volume: 8 Pages: 20-23

  • [Journal Article] The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte a-granule biogenesis2020

    • Author(s)
      Lo RW, Li L, Pluthero FG, Leung R, Eto K, Kahr WH
    • Journal Title

      Blood

      Volume: 136(6) Pages: 715-725

    • DOI

      10.1182/blood.2019004276

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ex vivo generation of platelet products from human iPS cells2020

    • Author(s)
      Nakamura S, Sugimoto N, Eto K.
    • Journal Title

      Inflamm Regen

      Volume: 40(1) Pages: 30-35

    • DOI

      10.1186/s41232-020-00139-2

    • Peer Reviewed / Open Access
  • [Journal Article] Novel platelet pharming using human induced pluripotent stem cells2020

    • Author(s)
      Flahou C, Sugimoto N, Eto K
    • Journal Title

      Bull Acad Natl Med

      Volume: 204(9) Pages: 961-970

    • DOI

      10.1016/j.banm.2020.09.040

    • Peer Reviewed
  • [Journal Article] 高機能血小板の大量培養法の開発2020

    • Author(s)
      杉本直志、江藤浩之
    • Journal Title

      実験医学

      Volume: 38(17) Pages: 185-191

  • [Journal Article] iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity2020

    • Author(s)
      1.Suzuki D, Flahou C, Yoshikawa N, Stirblyte I, Hayashi Y, Sawaguchi A, Akasaka M, Nakamura S, Higashi N, Xu H, Matsumoto T, Fujio K, Manz MG, Hotta A, Takizawa H, Eto K, Sugimoto N
    • Journal Title

      Stem Cell Reports.

      Volume: 14(1) Pages: 49-59

    • DOI

      10.1016/j.stemcr.2019.11.011

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel physico-chemical regulation mechanism enables the production of 100 billion platelets2020

    • Author(s)
      中村 壮、江藤浩之
    • Journal Title

      臨床血液

      Volume: 61 Issue: 6 Pages: 628-633

  • [Journal Article] Suppressive effects of anagrelide on cell cycle progression and the maturation of megakaryocyte progenitor cell lines in human induced pluripotent stem cells2020

    • Author(s)
      Takaishi K, Takeuchi M, Tsukamoto S, Takayama N, Oshima M, Kimura K, Isshiki Y, Kayamori K, Hino Y, Oshima-Hasegawa N, Mitsukawa S, Takeda Y, Mimura N, Ohwada C, Iseki T, Nakamura S, Eto K, Iwama A, Yokote K, Nakaseko C, Sakaida E
    • Journal Title

      Haematologica

      Volume: 105 Issue: 5 Pages: e216-e220

    • DOI

      10.3324/hematol.2018.214841

    • Peer Reviewed / Open Access
  • [Journal Article] SHARPIN at the Nexus of Platelet Integrin, Immune and Inflammatory Signaling2019

    • Author(s)
      Kasirer-Friede A, Tjahjono W, Eto K, Shattil SJ
    • Journal Title

      Proceeding of National Academy of Science of the United States of America

      Volume: 116 Issue: 11 Pages: 4983-4988

    • DOI

      10.1073/pnas.1819156116

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Turbulence activates platelet biogenesis to enable clinical scale ex vivo production2018

    • Author(s)
      Ito Y, Nakamura S, Sugimoto N, Shigemori T, Kato Y, Ohno M, Sakuma S, Ito K, Kumon H, Hirose H, Okamoto H, Nogawa M, Iwasaki M, Kihara S, Fujio K, Matsumoto T, Higashi N, Hashimoto K, Sawaguchi A, Harimoto KI, Nakagawa M, Yamamoto T, Handa M, Watanabe N, Nishi E, Arai F, Nishimura S, Eto K
    • Journal Title

      Cell

      Volume: 174(3) Pages: 636-648

    • DOI

      10.1016/j.cell.2018.06.011.

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation2018

    • Author(s)
      Kanda K, Sakamoto J, Ohno M, Nishi K, Eto K, Chiba T, Nishi E, Seno H et al.
    • Journal Title

      JCI insight

      Volume: 3(8) Pages: e91316

    • DOI

      10.1172/jci.insight.91316

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Spred1 safeguards hematopoietic homeostasis against diet-induced systemic stress2018

    • Author(s)
      Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M, Ueno M, Ohta K, Arai Y, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi H, Hirao A
    • Journal Title

      Cell Stem Cell

      Volume: 22(5) Pages: 713-725

    • DOI

      10.1016/j.stem.2018.04.002

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] β1-tubulin-based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production2018

    • Author(s)
      Seo H, Chen SJ, Hashimoto K, Endo H, Nishi Y, Ohta A, Yamamoto T, Hotta A, Sawaguchi A, Hayashi H, Koseki N, Murphy GJ, Fukuda K, Sugimoto N, Eto K
    • Journal Title

      Blood Advance

      Volume: 2 Pages: 2262-2272

    • DOI

      10.1182/bloodadvances.2018019547

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia2018

    • Author(s)
      Kanaji T, Vo MN, Kanaji S, Zarpellon A, Shapiro R, Morodomi Y, Yuzuriha S, Eto K, Belani R, Do MH, Yang XL, Ruggeri ZM, Schimmel P
    • Journal Title

      Proceeding of National Academy of Science of the United States of America

      Volume: 115 Issue: 35 Pages: E8228-E8235

    • DOI

      10.1073/pnas.1807000115

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Skewed megakaryopoiesis in human induced pluripotent stem cell-derived haematopoietic progenitor cells harbouring calreticulin mutations2018

    • Author(s)
      Takei H, Edahiro Y, Mano S, Masubuchi N, Mizukami Y, Imai M, Morishita S, Misawa K, Ochiai T, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N
    • Journal Title

      British Journal of Hematology

      Volume: 181 Pages: 791-802

    • DOI

      10.1111/bjh.15266

    • Peer Reviewed
  • [Journal Article] De novo mutations activating germline TP53 in an inherited bone marrow failure syndrome2018

    • Author(s)
      Toki T, Yoshida K, Wang RN, Nakamura S, Maekawa T, Goi K, Katoh MC, Mizuno S, Sugiyama F, Kanezaki R, Uechi T, Nakajima Y, Sato Y, Okuno Y, Sato-Otsubo A, Shiozawa Y, Kataoka K, Shiraishi Y, Sanada M, Chiba K, Tanaka H, Terui K, Sato T, Kamio T, Sakaguchi H, Ohga S, Kuramitsu M, Hamaguchi I, Ohara A, Kanno H, Miyano S, Kojima S, Ishiguro A, Sugita K, Kenmochi N, Takahashi S, Eto K, Ogawa S, Ito E
    • Journal Title

      American Journal of Human Genetics

      Volume: 103 Issue: 3 Pages: 440-447

    • DOI

      10.1016/j.ajhg.2018.07.020

    • Peer Reviewed
  • [Presentation] 血流シグナル解析から見えた新しい血小板造血マシナリー2021

    • Author(s)
      江藤浩之
    • Organizer
      第20回日本再生医療学会シンポジウム(web)
  • [Presentation] Novel platelet pharming using human iPS cells2021

    • Author(s)
      江藤浩之
    • Organizer
      French Academy of Science (web)
  • [Presentation] 乱流概念に基づく人工血小板製造法の開発戦略2020

    • Author(s)
      江藤浩之
    • Organizer
      第19回日本再生医療学会The Johnson & Johnson Innovation Award (Web)
  • [Presentation] iPS細胞による血小板再生2020

    • Author(s)
      杉本直志、江藤浩之
    • Organizer
      第19回日本再生医療学会 シンポジウム
  • [Presentation] iPS細胞を用いた血小板の作製2020

    • Author(s)
      中村 壮、江藤浩之
    • Organizer
      第14回日本血栓止血学会学術標準化委員会シンポジウム(Web)
  • [Presentation] iPS細胞由来血小板の研究開発と臨床応用2020

    • Author(s)
      杉本直志、江藤浩之
    • Organizer
      第41回日本炎症・再生医学会 シンポジウム(Web)
  • [Presentation] 自家iPS細胞由来血小板の臨床研究(iPLAT1)の経過報告2020

    • Author(s)
      諫田淳也, 杉本直志, 中村壮, 北野俊行, 菱澤方勝, 近藤忠一, 清水伸, 重政亜紀子, 平位秀世, 南学, 渡邊直英, 野川誠之, 半田誠, 岡本真一郎, 谷慶彦, 江藤浩之, 高折晃史
    • Organizer
      第82回日本血液学会学術集会プレナリーセッション, 京都
  • [Presentation] iPS細胞由来人工血小板再構成とfirst in human study2020

    • Author(s)
      江藤浩之
    • Organizer
      第24回日本心不全学会シンポジウム(web)
  • [Presentation] 医学と医療の新展開2019

    • Author(s)
      江藤浩之
    • Organizer
      日本医学会総会 再生医療への招待 シンポジウム, 名古屋
  • [Presentation] Turning Stem Cells into Platelets for Next Generation Transfusion2019

    • Author(s)
      江藤浩之
    • Organizer
      日本血液学会国際シンポジウム、伊勢志摩
  • [Presentation] iPS血小板の開発と臨床応用2019

    • Author(s)
      杉本直志
    • Organizer
      第18回先端医療フォーラム、東京
  • [Presentation] Development of turbulence-based production of iPSC-derived platelets towards clinical application and beyond2019

    • Author(s)
      江藤浩之
    • Organizer
      国際幹細胞学会(ISSCR)シンポジウム, Los Angeles, USA
  • [Presentation] Beyond ex vivo platelet biogenesis2019

    • Author(s)
      江藤浩之
    • Organizer
      国際血栓止血学会 (ISTH) State of Artsシンポジウム、Melbourne, Australia
  • [Presentation] 血小板産生機構in vivoとin vitro2019

    • Author(s)
      江藤浩之
    • Organizer
      Research PlaNet, 熊本
  • [Presentation] Ex Vivo Manufacturing Platelet towards an alternative transfusion product2019

    • Author(s)
      江藤浩之
    • Organizer
      深圳 Biotechサミット、深圳 、中華人民共和国
  • [Presentation] iPS細胞を用いた血小板製剤の臨床応用の展望2019

    • Author(s)
      杉本直志、江藤浩之
    • Organizer
      第43回日本血液事業学会シンポジウム、仙台
  • [Presentation] iPS細胞技術を用いた造血システムの再構成と治療への応用2019

    • Author(s)
      杉本直志、江藤浩之
    • Organizer
      第81回日本血液学会総会、東京
  • [Presentation] Industrial scale manufacturing platelets using iPS cell technology2019

    • Author(s)
      江藤浩之
    • Organizer
      日印再生医療センター年次大会、東京
  • [Presentation] Turning Stem Cells into Platelets2019

    • Author(s)
      江藤浩之
    • Organizer
      第17回 国際輸血代替物学会シンポジウム、奈良
  • [Presentation] Ex vivo Bioengineering of Platelets2019

    • Author(s)
      江藤浩之
    • Organizer
      第61回 米国血液学会総会、教育講演、Orland, Florida, USA
  • [Presentation] Physico-chemical因子の発見2018

    • Author(s)
      江藤浩之
    • Organizer
      第91回日本生化学会総会“シンポジウム 橋渡し研究のシーズとなった止血血栓学領域の基礎研究”京都
  • [Presentation] Clinical application strategy of in vitro generated platelets2018

    • Author(s)
      江藤浩之
    • Organizer
      Thailand Thrombosis Meeting (Mahidon University, Bangkok)シンポジウム
  • [Presentation] Designing clinical scale production of iPSC-derived platelets by a novel flow concept2018

    • Author(s)
      江藤浩之
    • Organizer
      European Hematology Association Meeting, Stockholm, Sweden EHA-JHAジョイントシンポジウム
  • [Presentation] iPS細胞からの血小板製剤の作製2018

    • Author(s)
      杉本直志、江藤浩之
    • Organizer
      日本輸血・細胞治療学会シンポジウム、宇都宮
  • [Presentation] iPS細胞の再生医療への応用 : 血小板再生戦略2018

    • Author(s)
      江藤浩之
    • Organizer
      交通医学会総会シンポジウム、大阪
  • [Presentation] Turbulence activates platelet biogenesis in megakaryocytes2018

    • Author(s)
      江藤浩之
    • Organizer
      Platelets 10th International Symposium, Ramat Gan (Tel Aviv), Israel
  • [Patent(Industrial Property Rights)] 巨核球および血小板を含む凍結乾燥製剤2022

    • Inventor(s)
      江藤浩之、大鳥精司、志賀康浩、小坂健太朗
    • Industrial Property Rights Holder
      京都大学、千葉大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      特許第7058431号
  • [Patent(Industrial Property Rights)] 巨核球および血小板を含む凍結乾燥製剤2021

    • Inventor(s)
      江藤浩之、大鳥精司、志賀康浩、小坂健太朗
    • Industrial Property Rights Holder
      京都大学、千葉大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      特願2021-516510
  • [Patent(Industrial Property Rights)] 血小板の製造方法2018

    • Inventor(s)
      江藤浩之、中村壮、伊東幸敬
    • Industrial Property Rights Holder
      京都大学、株式会社メガカリオン
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      PCT/JP2018/008279, JP : 特願2019-504562 ; US 16/491,219 ; EP 18763555.2
    • Overseas
  • [Patent(Industrial Property Rights)] 血小板の製造方法および製造装置、ならびに血小板の製造装置における運転条件の決定方法2018

    • Inventor(s)
      江藤浩之、中村壮、伊東幸敬、重盛智大、加藤好一
    • Industrial Property Rights Holder
      京都大学、株式会社メガカリオン、佐竹化学機械工業株式会社(現 : 佐竹マルチミックス)
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      PCT/JP2018/025537(WO2019/009364A1), JP : 特願2019-527964 ; US : 16/628, 451 ; EP : 828313.9
    • Overseas

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Published: 2024-03-28  

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