2019 Fiscal Year Annual Research Report
キラーＴ細胞のエネルギー代謝機構の解析とＰＤ－１阻害がん免疫治療の効果予測
| Project/Area Number |
18J15051
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| Research Institution | Kyoto University |
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Principal Investigator |
Kumar Alok 京都大学, 医学研究科, 特別研究員(DC2)
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| Project Period (FY) |
2018-04-25 – 2020-03-31
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| Keywords | PD-1 / Immunosupression / PGC-1alpha / Biomarker / Mitochondrial activation |
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| Outline of Annual Research Achievements |
We classified unresponsiveness reasons into i). unresponsvieness because of local reasons ii). unresponsiveness because of having systemic immunosuppressive property (SIP). In addition, we found immune response after PD-1 blockade is associated with mitochondrial activation. Based on this result, we concluded that mitochondrial activation could be biomarker to identify responder and nonresponders. Further, we found SIP-positive tumors release non-proteinaceous small molecule that inhibit mitochondrial activation and proliferation of T cells. Bezafibrate when used alongwith culture superntant cancels the suppressive effect of supernatnat. Bezafibrate treatment alongwith PD-1 blockade enhances the survival of host bearing SIP-positive tumor compared to PD-1 blockade alone.
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| Research Progress Status |
令和元年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和元年度が最終年度であるため、記入しない。
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