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2020 Fiscal Year Annual Research Report

Interaction between cell membrane and nuclear hormone receptor in brain development and its modification by environmental chemicals

Research Project

Project/Area Number 18J23449
Research InstitutionGunma University

Principal Investigator

アリヤニ ウィンダ  群馬大学, 医学系研究科, 特別研究員(PD)

Project Period (FY) 2018-04-25 – 2021-03-31
KeywordsThyroid hormone / non-genomic / migration / proliferation / integrin / GPER / gadolinium / isoflavones
Outline of Annual Research Achievements

Last year, I have tried to finish my research project in the interaction of environmental chemicals and thyroid hormones (TH) with the nuclear receptor (thyroid hormone receptor and estrogen receptor) or cell surface receptor (integrin and GPER1/GPR30) that regulate cell proliferation, migration, neuritogenesis, and synaptogenesis. The results revealed that thyroid hormones induced cell migration and proliferation through TRα-dependent and TR-independent pathways. The thyroid hormone-induced cell migration and proliferation through the activation of Grb2 leads to activate the TR-independent pathways. In addition, environmental chemicals such as isoflavones or gadolinium-based contrast agents (GBCAs) accelerate cell migration through GPER1 or integrin activation, which leads to activate FAK/PI3K/Akt/Rho-GTPase pathways that induced F-actin re-arrangement. TH and isoflavones also induced dendritogenesis and synaptogenesis in Purkinje cells via different mechanism pathways, TRα and ERα, respectively. Cell fractionation assays showed that isoflavones induced localization of SNARE protein to the membrane and dendritic fraction, indicate the synapse formation. Isoflavones and TH also increased the expression level of both pre- and post-synaptic proteins. Now, I am preparing several manuscripts to publish my research results. We plan to publish our results in several international journals.

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

  • Research Products

    (5 results)

All 2021 2020

All Journal Article (2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] A Novel Role of Nuclear and Membrane Receptor on Isoflavone-Induced Neuritogenesis and Synaptogenesis2021

    • Author(s)
      Ariyani Winda、Miyazaki Wataru、Koibuchi Noriyuki
    • Journal Title

      Journal of the Endocrine Society

      Volume: 5 Pages: A802~A803

    • DOI

      10.1210/jendso/bvab048.1632

  • [Journal Article] Soy Isoflavones Accelerate Glial Cell Migration via GPER-Mediated Signal Transduction Pathway2020

    • Author(s)
      Ariyani Winda、Miyazaki Wataru、Amano Izuki、Hanamura Kenji、Shirao Tomoaki、Koibuchi Noriyuki
    • Journal Title

      Frontiers in Endocrinology

      Volume: 11 Pages: 554941

    • DOI

      10.3389/fendo.2020.554941

  • [Presentation] 甲状腺ホルモンは膜受容体を介し、星状膠細胞の移動に影響する.2021

    • Author(s)
      Winda Ariyani, 航 宮崎, 鯉淵 典之
    • Organizer
      第98回 日本生理学会大会
  • [Presentation] A novel role of nuclear and membrane receptor on isoflavone-induced neuritogenesis and synaptogenesis2021

    • Author(s)
      Winda Ariyani, Wataru Miyazaki, Noriyuki Koibuchi
    • Organizer
      The 103rd Annual Meeting of the Endocrine Society: ENDO2021
    • Int'l Joint Research / Invited
  • [Presentation] Gadolinium-based contrast agents induced cell migration through integrin αvβ3 signaling pathway2020

    • Author(s)
      Winda Ariyani, Wataru Miyazaki, Yoshito Tsushima, Noriyuki Koibuchi.
    • Organizer
      The Kitakanto Medical Journal Annual Meeting

URL: 

Published: 2021-12-27  

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